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EPS8L2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248468

MBS248468 is an antibody targeting EPS8L2. Also known as Rabbit Polyclonal (IgG) to Human EPS8L2. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
EPS8L2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human EPS8L2
Product Gene Name
Product Synonym Names
Anti-EPS8L2 Antibody (aa1-50) IHC-plus; EPS8L2; EPS8-like 2; EPS8-related protein 2; EPS8R2; Human EPS8L2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
ES8L2 Antibody detects endogenous levels of total ES8L2 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
82,323 Da
OMIM
614988
3D Structure
ModBase 3D Structure for Q9H6S3
Target Species
Human
Immunogen Description
Synthetic peptide from human ES8L2 (aa1-50).
Immunogen
EPS8L2 antibody was raised against synthetic peptide from human ES8L2 (aa1-50).
Antigen Modification
aa1-50
Applications Tested/Suitable for anti-EPS8L2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-EPS8L2 antibody
ELISA (1:40000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-EPS8L2 antibody

Anti-EPS8L2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-EPS8L2 Polyclonal Antibody – Cat# MBS248468

Immunohistochemistry (IHC) of anti-EPS8L2 antibody

Anti-EPS8L2 antibody IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-EPS8L2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS248468

Western Blot (WB) of anti-EPS8L2 antibody

Western blot of extracts from HeLa/Jurkat/HUVEC cells, using ES8L2 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-EPS8L2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248468

Other Notes

Small volumes of anti-EPS8L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EPS8L2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
epidermal growth factor receptor kinase substrate 8-like protein 2
NCBI Official Synonym Full Names
EPS8-like 2
NCBI Official Symbol
EPS8L2
NCBI Official Synonym Symbols
EPS8R2
UniProt Protein Name
Epidermal growth factor receptor kinase substrate 8-like protein 2
UniProt Synonym Protein Names
Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8-related protein 2
UniProt Gene Name
EPS8L2
UniProt Synonym Gene Names
EPS8R2; EPS8-like protein 2; EPS8-related protein 2
UniProt Entry Name
ES8L2_HUMAN
NCBI Protein Information
epidermal growth factor receptor kinase substrate 8-like protein 2; EPS8-like protein 2; EPS8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2

NCBI Summary for EPS8L2

This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]

UniProt Comments for EPS8L2

EPS8L2: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. Belongs to the EPS8 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; Actin-binding; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: protein complex; cytoplasm; plasma membrane; vesicle

Molecular Function: Rho guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; actin binding

Biological Process: regulation of Rho protein signal transduction; Rho protein signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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