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ERF3B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6296469

ERF3B encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be… More details

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Product Overview

Online Datasheet in PDF
Product Name
ERF3B, Polyclonal Antibody
Full Product Name
ERF3B, ID (GSPT2, ERF3B, Eukaryotic peptide chain release factor GTP-binding subunit ERF3B, G1 to S phase transition protein 2 homolog) (PE)
Product Gene Name
anti-ERF3B antibody
Product Synonym Gene Name
GSPT2
Product Synonym Names
GSPT2; ERF3B; Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; G1 to S phase transition protein 2 homolog
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
68,883 Da
OMIM
300418
3D Structure
ModBase 3D Structure for Q8IYD1
Immunogen
ERF3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223~253 amino acids from the Central region of human ERF3B.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-ERF3B antibody

Antibodies; Binding Proteins
Applications Tested/Suitable for anti-ERF3B antibody
Western Blot (WB), FLISA
Application Notes for anti-ERF3B antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ERF3B antibody

ERF3B Antibody (Center) western blot analysis in 293 cell line and mouse stomach tissue lysates (35ug/lane).This demonstrates the ERF3B antibody detected the ERF3B protein (arrow).
Rabbit Anti-ERF3B Polyclonal Antibody – Cat# MBS6296469

Product References and Citations for anti-ERF3B antibody

Cheng, Z., et al. Genes Dev. 23(9):1106-1118(2009). Zhouravleva, G., et al. IUBMB Life 58(4):199-202(2006). Chauvin, C., et al. Mol. Cell. Biol. 25(14):5801-5811(2005). Hoshino, S., et al. J. Biol. Chem. 274(24):16677-16680(1999). Hansen, L.L., et al. Cytogenet. Cell Genet. 86 (3-4), 250-251 (1999).

Other Notes

Small volumes of anti-ERF3B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ERF3B purchase

MBS6296469 is an antibody targeting ERF3B. Also known as ERF3B, ID (GSPT2, ERF3B, Eukaryotic peptide chain release factor GTP-binding subunit ERF3B, G1 to S phase transition protein 2 homolog) (PE). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ERF3B. It may not necessarily be applicable to this product.

NCBI GI #
46094014
NCBI GeneID
23708
NCBI Accession #
NP_060564
UniProt Primary Accession #
Q8IYD1
UniProt Secondary Accession #
Q9H909; Q9NVY0; Q9NY44
UniProt Related Accession #
Q8IYD1
GenBank Nucleotide #
NM_018094.4
NCBI Official Full Name
eukaryotic peptide chain release factor GTP-binding subunit ERF3B
NCBI Official Synonym Full Names
G1 to S phase transition 2
NCBI Official Symbol
GSPT2
NCBI Official Synonym Symbols
GST2; ERF3B
UniProt Protein Name
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B
UniProt Synonym Protein Names
G1 to S phase transition protein 2 homolog
Protein Family
Eukaryotic peptide chain release factor GTP-binding
UniProt Gene Name
GSPT2
UniProt Synonym Gene Names
ERF3B; Eukaryotic peptide chain release factor subunit 3b; eRF3b
UniProt Entry Name
ERF3B_HUMAN
NCBI Protein Information
eukaryotic peptide chain release factor GTP-binding subunit ERF3B

NCBI Summary for ERF3B

This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]
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UniProt Comments for ERF3B

GSPT2: Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Belongs to the GTP-binding elongation factor family. ERF3 subfamily.

Protein type: Hydrolase; RNA-binding; Translation

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: cytosol

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: cellular protein metabolic process; translation; mRNA catabolic process, nonsense-mediated decay; gene expression; translational termination; cell cycle
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Research Articles on ERF3B

1. The tumor marker eRF3B can change the cell cycle and influence the phosphorylation status of 4E-BP1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ERF3B antibody

 Products by Pathway  Pathway Diagram
 Eukaryotic Translation Termination Pathway antibodies  Eukaryotic Translation Termination Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Nonsense Mediated Decay (NMD) Enhanced By The Exon Junction Complex (EJC) Pathway antibodies  Nonsense Mediated Decay (NMD) Enhanced By The Exon Junction Complex (EJC) Pathway Diagram
 Nonsense Mediated Decay (NMD) Independent Of The Exon Junction Complex (EJC) Pathway antibodies  Nonsense Mediated Decay (NMD) Independent Of The Exon Junction Complex (EJC) Pathway Diagram
 Nonsense-Mediated Decay (NMD) Pathway antibodies  Nonsense-Mediated Decay (NMD) Pathway Diagram
 Translation Pathway antibodies  Translation Pathway Diagram
 Translation Factors Pathway antibodies  Translation Factors Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram

Diseases associated with anti-ERF3B antibody

 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >1 publications with ERF3B and Neurobehavioral Manifestations
 Liver Diseases Antibodies  >1 publications with ERF3B and Liver Diseases
 Hepatitis Antibodies  >1 publications with ERF3B and Hepatitis
 Liver Neoplasms Antibodies  >1 publications with ERF3B and Liver Neoplasms
 Adenocarcinoma Antibodies  >1 publications with ERF3B and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with ERF3B and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-ERF3B antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with ERF3B and Brain
 Mammary Gland Antibodies  >1 publications with ERF3B and Mammary Gland
 Thyroid Antibodies  >1 publications with ERF3B and Thyroid
 Prostate Antibodies  >1 publications with ERF3B and Prostate
 Blood Antibodies  >1 publications with ERF3B and Blood
 Liver Antibodies  >1 publications with ERF3B and Liver
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