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ESR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6296780

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ESR1, Polyclonal Antibody
Full Product Name
ESR1 isoform 1, NT (ESR1, ESR, NR3A1, Estrogen receptor, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1) (Biotin)
Product Gene Name
anti-ESR1 antibody
Product Synonym Names
ESR1; ESR; NR3A1; Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
66,216 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (152011631..152424409). Location: 6q25.1
OMIM
133430
3D Structure
ModBase 3D Structure for P03372
Immunogen
ESR1 isoform1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-157 amino acids from the N-terminal region of human ESR1 isoform1.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-ESR1 antibody

Antibodies; Receptors; Estrogen
Applications Tested/Suitable for anti-ESR1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ESR1 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ESR1 antibody

ESR1 isoform1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ESR1 isoform1 antibody detected the ESR1 isoform1 protein (arrow).
Rabbit Anti-ESR1 Polyclonal Antibody – Cat# MBS6296780

Western Blot (WB) of anti-ESR1 antibody

ESR1 isoform1 Antibody (N-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the ESR1 isoform1 antibody detected the ESR1 isoform1 protein (arrow).
Rabbit Anti-ESR1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6296780

Product References and Citations for anti-ESR1 antibody

Geradts, J., et al. Cancer Invest. 28(9):969-977(2010). Hayes, D.F., et al. Clin. Pharmacol. Ther. 88(5):626-629(2010). Lupien, M., et al. Genes Dev. 24(19):2219-2227(2010). Corbo, R.M., et al. J. Gerontol. A Biol. Sci. Med. Sci. (2010). In press: Kim, S., et al. Fertil. Steril. (2010).

Other Notes

Small volumes of anti-ESR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ESR1 purchase

MBS6296780 is an antibody targeting ESR1. Also known as ESR1 isoform 1, NT (ESR1, ESR, NR3A1, Estrogen receptor, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1) (Biotin). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ESR1. It may not necessarily be applicable to this product.

NCBI GI #
62821794
NCBI GeneID
2099
NCBI Accession #
NP_000116.2
NCBI Related Accession #
NP_001116212.1; NP_001116213.1; NP_001116214.1
UniProt Primary Accession #
P03372
UniProt Secondary Accession #
Q13511; Q14276; Q5T5H7; Q6MZQ9; Q9NU51; Q9UDZ7; Q9UIS7
UniProt Related Accession #
P03372
GenBank Nucleotide #
NM_000125.3
NCBI Official Full Name
estrogen receptor
NCBI Official Synonym Full Names
estrogen receptor 1
NCBI Official Symbol
ESR1
NCBI Official Synonym Symbols
ER; ESR; Era; ESRA; NR3A1
UniProt Protein Name
Estrogen receptor
UniProt Synonym Protein Names
ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
Protein Family
Estrogen receptor
UniProt Gene Name
ESR1
UniProt Synonym Gene Names
ESR; NR3A1; ER
UniProt Entry Name
ESR1_HUMAN
NCBI Protein Information
estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha delta 4 +49 isoform; nuclear receptor subfamily 3 group A member 1; estrogen

UniProt Comments for ESR1

ER-alpha: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: nucleoplasm; Golgi apparatus; membrane; cytoplasm; plasma membrane; integral to membrane; nucleus

Molecular Function: identical protein binding; estrogen receptor activity; zinc ion binding; nitric-oxide synthase regulator activity; beta-catenin binding; estrogen response element binding; transcription factor binding; steroid binding; protein binding; enzyme binding; steroid hormone receptor activity; chromatin binding; transcription factor activity

Biological Process: estrogen receptor signaling pathway; positive regulation of nitric oxide biosynthetic process; uterus development; signal transduction; response to estradiol stimulus; regulation of apoptosis; positive regulation of fibroblast proliferation; elevation of cytosolic calcium ion concentration; regulation of transcription, DNA-dependent; epithelial cell development; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; antral ovarian follicle growth; positive regulation of nitric-oxide synthase activity; negative regulation of transcription factor activity; male gonad development; androgen metabolic process; vagina development; positive regulation of retinoic acid receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; chromatin remodeling; response to estrogen stimulus; gene expression; positive regulation of transcription factor activity; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling

Disease: Breast Cancer; Migraine With Or Without Aura, Susceptibility To, 1; Myocardial Infarction, Susceptibility To; Estrogen Resistance
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Research Articles on ESR1

1. The expression of deltaEF1 is up-regulated by 17beta-estradiol (E2) in MCF-7 cells in an ER-alpha-dependent manner.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ESR1 antibody

 Reference Product  PubMed Publications
 ESR2 antibody  >235 publications with ESR1 and ESR2
 JUN antibody  >100 publications with ESR1 and JUN
 PGR antibody  >89 publications with ESR1 and PGR
 ERBB2 antibody  >45 publications with ESR1 and ERBB2
 BRCA1 antibody  >27 publications with ESR1 and BRCA1
 MYC antibody  >25 publications with ESR1 and MYC
 EGFR antibody  >20 publications with ESR1 and EGFR
 CCND1 antibody  >19 publications with ESR1 and CCND1
 TP53 antibody  >14 publications with ESR1 and TP53
 SP1 antibody  >11 publications with ESR1 and SP1

Pathways associated with anti-ESR1 antibody

 Products by Pathway  Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 FOXM1 Transcription Factor Network Pathway antibodies  FOXM1 Transcription Factor Network Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram

Diseases associated with anti-ESR1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >349 publications with ESR1 and Neoplasms
 Breast Neoplasms Antibodies  >220 publications with ESR1 and Breast Neoplasms
 Female Urogenital Diseases Antibodies  >87 publications with ESR1 and Female Urogenital Diseases
 Carcinoma Antibodies  >85 publications with ESR1 and Carcinoma
 Adenocarcinoma Antibodies  >43 publications with ESR1 and Adenocarcinoma
 Disease Progression Antibodies  >38 publications with ESR1 and Disease Progression
 Bone Diseases, Metabolic Antibodies  >35 publications with ESR1 and Bone Diseases, Metabolic
 Obesity Antibodies  >32 publications with ESR1 and Obesity
 Coronary Artery Disease Antibodies  >23 publications with ESR1 and Coronary Artery Disease
 Prostatic Neoplasms Antibodies  >22 publications with ESR1 and Prostatic Neoplasms

Organs/Tissues associated with anti-ESR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >78 publications with ESR1 and Brain
 Uterus Antibodies  >60 publications with ESR1 and Uterus
 Ovary Antibodies  >52 publications with ESR1 and Ovary
 Heart Antibodies  >41 publications with ESR1 and Heart
 Testis Antibodies  >38 publications with ESR1 and Testis
 Prostate Antibodies  >33 publications with ESR1 and Prostate
 Muscle Antibodies  >28 publications with ESR1 and Muscle
 Connective Tissue Antibodies  >26 publications with ESR1 and Connective Tissue
 Lung Antibodies  >25 publications with ESR1 and Lung
 Lymph Node Antibodies  >17 publications with ESR1 and Lymph Node
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