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FAF1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3903154

FAS-associated factor 1 (FAF1) binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis FAF1 requires a ubiquitin-like domain but not the FAS-binding domain [taken from NCBI Entrez Gene (Gene… More details

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Product Overview

Online Datasheet in PDF
Product Name
FAF1, Polyclonal Antibody
Full Product Name
Rabbit anti-FAF1 Antibody, Affinity Purified
Product Gene Name
anti-FAF1 antibody
Product Synonym Names
hFAF1; UBXN3A; UBXD12; UBX domain-containing protein 3A; UBX domain-containing protein 12; UBX domain protein 3A; HFAF1s; FAS-associated factor 1; Fas (TNFRSF6) associated factor 1; CGI-03; TNFRSF6-associated factor 1; FAS-associated factor 1; Fas associated factor 1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
200ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
73,954 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (50906935..51425936, complement). Location: 1p33
OMIM
604460
3D Structure
ModBase 3D Structure for Q9UNN5
Predicted Reactivity
Rat
Immunogen
Between 25 and 75
Conjugation
Unconjugated

Product Categories/Family for anti-FAF1 antibody

Primary Antibodies
Applications Tested/Suitable for anti-FAF1 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-FAF1 antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate
IHC: 1:100-1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-FAF1 antibody

Detection of human FAF1 by immunohistochemistry. Sample: FFPE section of human ovarian carcinoma (left) and human colon carcinoma (right). Antibody: Affinity purified rabbit anti-FAF1 (Cat. No. MBS3903154 Lot1) used at a dilution of 1:200 (1ug/ml). Detection: DAB
Rabbit Anti-FAF1 Polyclonal Antibody – Cat# MBS3903154

Western Blot (WB) of anti-FAF1 antibody

Detection of human and mouse FAF1 by western blot (h&m) and immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), HEK293T (T; 50 ug), and mouse NIH 3T3 (M; 50 ug) cells. Antibodies: Affinity purified rabbit anti-FAF1 antibody MBS3903154 used for WB at 0.04 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. FAF1 was also immunoprecipitated by rabbit anti-FAF1 antibody MBS3903155, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B).
Rabbit Anti-FAF1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3903154

Other Notes

Small volumes of anti-FAF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FAF1 purchase

MBS3903154 is an antibody targeting FAF1. Also known as Rabbit anti-FAF1 Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FAF1. It may not necessarily be applicable to this product.

NCBI GI #
5901948
NCBI GeneID
11124
NCBI Accession #
NP_008982.1
UniProt Primary Accession #
Q9UNN5
UniProt Secondary Accession #
Q9UF34; Q9UNT3; Q9Y2Z3
UniProt Related Accession #
Q9UNN5
GenBank Nucleotide #
NM_007051.2
NCBI Official Full Name
FAS-associated factor 1
NCBI Official Synonym Full Names
Fas (TNFRSF6) associated factor 1
NCBI Official Symbol
FAF1
NCBI Official Synonym Symbols
hFAF1; CGI-03; HFAF1s; UBXD12; UBXN3A; FLJ37524
UniProt Protein Name
FAS-associated factor 1
UniProt Synonym Protein Names
UBX domain-containing protein 12; UBX domain-containing protein 3A
Protein Family
FAS-associated factor
UniProt Gene Name
FAF1
UniProt Synonym Gene Names
UBXD12; UBXN3A; hFAF1
UniProt Entry Name
FAF1_HUMAN
NCBI Protein Information
FAS-associated factor 1; OTTHUMP00000009649; OTTHUMP00000009650; OTTHUMP00000009651; UBX domain protein 3A; TNFRSF6-associated factor 1; UBX domain-containing protein 12; UBX domain-containing protein 3A

UniProt Comments for FAF1

FAF1: a pro-apoptotic protein that binds to FAS antigen. Potentiates but cannot initiate FAS-induced apoptosis. Its pro-apoptotic activity requires a ubiquitin-like domain but not the FAS-binding domain. Phosphorylation by protein kinase CK2 influences transport into nucleus. Two transcript variants encoding different protein isoforms have been described.

Protein type: Apoptosis; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1p33

Cellular Component: perinuclear region of cytoplasm; CD95 death-inducing signaling complex; nuclear envelope; nucleus; cytosol

Molecular Function: NF-kappaB binding; protein domain specific binding; protein binding; ubiquitin binding; ubiquitin protein ligase binding; heat shock protein binding; protein kinase regulator activity; protein kinase binding

Biological Process: regulation of cell adhesion; cell death; proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein complex assembly; cytoplasmic sequestering of NF-kappaB; positive regulation of apoptosis; apoptosis; regulation of protein catabolic process; regulation of protein kinase activity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FAF1 antibody

 Reference Product  PubMed Publications
 FAS antibody  >66 publications with FAF1 and FAS
 VCP antibody  >10 publications with FAF1 and VCP
 CASP8 antibody  >8 publications with FAF1 and CASP8
 FADD antibody  >5 publications with FAF1 and FADD
 TRPV1 antibody  >2 publications with FAF1 and TRPV1
 CFLAR antibody  >1 publications with FAF1 and CFLAR
 RELA antibody  >1 publications with FAF1 and RELA

Pathways associated with anti-FAF1 antibody

 Products by Pathway  Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with anti-FAF1 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >10 publications with FAF1 and Necrosis
 Carcinoma Antibodies  >7 publications with FAF1 and Carcinoma
 Nervous System Diseases Antibodies  >4 publications with FAF1 and Nervous System Diseases
 Adenocarcinoma Antibodies  >3 publications with FAF1 and Adenocarcinoma
 Lymphoma Antibodies  >2 publications with FAF1 and Lymphoma
 Breast Neoplasms Antibodies  >2 publications with FAF1 and Breast Neoplasms
 Inflammation Antibodies  >2 publications with FAF1 and Inflammation
 Cardiovascular Diseases Antibodies  >1 publications with FAF1 and Cardiovascular Diseases
 Uterine Cervical Neoplasms Antibodies  >1 publications with FAF1 and Uterine Cervical Neoplasms
 Lung Neoplasms Antibodies  >1 publications with FAF1 and Lung Neoplasms

Organs/Tissues associated with anti-FAF1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with FAF1 and Blood
 Brain Antibodies  >5 publications with FAF1 and Brain
 Embryonic Tissue Antibodies  >3 publications with FAF1 and Embryonic Tissue
 Lung Antibodies  >3 publications with FAF1 and Lung
 Muscle Antibodies  >2 publications with FAF1 and Muscle
 Stomach Antibodies  >2 publications with FAF1 and Stomach
 Nerve Antibodies  >2 publications with FAF1 and Nerve
 Prostate Antibodies  >2 publications with FAF1 and Prostate
 Ovary Antibodies  >2 publications with FAF1 and Ovary
 Thyroid Antibodies  >1 publications with FAF1 and Thyroid
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