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FKBP1B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6475990

MBS6475990 is an antibody targeting FKBP1B. Also known as FKBP1B, NT (h-FKBP-12, Immunophilin FKBP12.6, 12.6kD FK506-binding Protein, 12.6kD FKBP, FKBP-12.6, Rotamase, FK506-binding Protein 1B, FKBP-1B, Peptidyl-prolyl cis-trans Isomerase FKBP1B, PPIase… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FKBP1B, Polyclonal Antibody
Full Product Name
FKBP1B, NT (h-FKBP-12, Immunophilin FKBP12.6, 12.6kD FK506-binding Protein, 12.6kD FKBP, FKBP-12.6, Rotamase, FK506-binding Protein 1B, FKBP-1B, Peptidyl-prolyl cis-trans Isomerase FKBP1B, PPIase FKBP1B, FKBP12.6, FKBP1L, FKBP9, OTK4) (PE)
Product Gene Name
anti-FKBP1B antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human FKBP1B. Species Crossreactivity: mouse.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
14.2 kDa (130aa), confirmed by MALDI-TOF
OMIM
600620
3D Structure
ModBase 3D Structure for P68106
Immunogen
KLH-conjugated synthetic peptide corresponding to a fragment of amino acids located between corresponding to a portion of amino acids within aa16-46 in the N-terminal region of human FKBP1B.
Conjugate
PE
Note
Preservative Free

Product Categories/Family for anti-FKBP1B antibody

Antibodies; Binding Proteins
Applications Tested/Suitable for anti-FKBP1B antibody
Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-FKBP1B antibody
IHC: 1:10-1:50
ICC/IF: 1:10-1:50
WB: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-FKBP1B antibody

Western blot analysis of FKBP1B antibody (N-term) in 293 cell line lysates (35ug/lane). FKBP1B (arrow) was detected using the purified Pab.
Rabbit Anti-FKBP1B Polyclonal Antibody – Cat# MBS6475990

Western Blot (WB) of anti-FKBP1B antibody

Western blot analysis of FKBP1B antibody (N-term) in mouse cerebellum tissue lysates (35ug/lane). FKBP1B (arrow) was detected using the purified Pab.
Rabbit Anti-FKBP1B Polyclonal Antibody, Western Blot (WB) – Cat# MBS6475990

Immunohistochemistry (IHC) of anti-FKBP1B antibody

FKBP1B Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FKBP1B Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-FKBP1B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6475990

Immunofluorescence (IF) of anti-FKBP1B antibody

Confocal immunofluorescent analysis of FKBP1B Antibody (N-term) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-FKBP1B Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6475990

Product References and Citations for anti-FKBP1B antibody

1. Arakawa H., Nagase H.Biochem. Biophys. Res. Commun. 200:836-843(1994). 2. Lam E., Martin M.M., Timerman A.P.Biol. Chem. 270:26511-26522(1995). 3. Deivanayagam C.C., Carson M.Acta Crystallogr. D 56:266-271(2000).

Other Notes

Small volumes of anti-FKBP1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP1B. It may not necessarily be applicable to this product.

NCBI GI #
4758380
NCBI GeneID
2281
NCBI Accession #
NP_004107
UniProt Primary Accession #
P68106
UniProt Secondary Accession #
Q13664; Q16645; Q53TM2; Q9BQ40
UniProt Related Accession #
P68106
GenBank Nucleotide #
NM_004116.4
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase FKBP1B isoform a
NCBI Official Synonym Full Names
FK506 binding protein 1B
NCBI Official Symbol
FKBP1B
NCBI Official Synonym Symbols
OTK4; FKBP1L; PKBP1L; PPIase; FKBP12.6
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP1B
UniProt Synonym Protein Names
12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FKBP-12.6; FK506-binding protein 1B; FKBP-1B; Immunophilin FKBP12.6; Rotamase; h-FKBP-12
Protein Family
Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name
FKBP1B
UniProt Synonym Gene Names
FKBP12.6; FKBP1L; FKBP9; OTK4; PPIase FKBP1B; 12.6 kDa FKBP; FKBP-12.6; FKBP-1B
UniProt Entry Name
FKB1B_HUMAN
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP1B

NCBI Summary for FKBP1B

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for FKBP1B

FKBP1B: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Isomerase; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: sarcoplasmic reticulum membrane; membrane; cytoplasm; Z disc; cytosol

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; cyclic nucleotide binding; calcium channel inhibitor activity; ryanodine-sensitive calcium-release channel activity; receptor binding

Biological Process: positive regulation of sequestering of calcium ion; positive regulation of axon regeneration; protein maturation via protein folding; protein peptidyl-prolyl isomerization; cytosolic calcium ion homeostasis; negative regulation of heart rate; response to redox state; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; T cell proliferation; negative regulation of protein phosphatase type 2B activity; response to vitamin E; smooth muscle contraction; 'de novo' protein folding; response to hydrogen peroxide; insulin secretion; negative regulation of release of sequestered calcium ion into cytosol; action potential propagation; response to glucose stimulus; protein refolding; transmembrane transport
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Research Articles on FKBP1B

1. Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FKBP1B antibody

 Reference Product  PubMed Publications
 RYR2 antibody  >5 publications with FKBP1B and RYR2

Pathways associated with anti-FKBP1B antibody

 Products by Pathway  Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ion Homeostasis Pathway antibodies  Ion Homeostasis Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-FKBP1B antibody

 Disease Name  Pubmed Publications
 Tachycardia, Ventricular Antibodies  >2 publications with FKBP1B and Tachycardia, Ventricular
 Ventricular Fibrillation Antibodies  >1 publications with FKBP1B and Ventricular Fibrillation
 Atrial Fibrillation Antibodies  >1 publications with FKBP1B and Atrial Fibrillation
 Cardiomyopathies Antibodies  >1 publications with FKBP1B and Cardiomyopathies
 Arrhythmias, Cardiac Antibodies  >1 publications with FKBP1B and Arrhythmias, Cardiac
 Hypertension Antibodies  >1 publications with FKBP1B and Hypertension
 Heart Failure Antibodies  >1 publications with FKBP1B and Heart Failure
 Hyperplasia Antibodies  >1 publications with FKBP1B and Hyperplasia
 Disease Models, Animal Antibodies  >1 publications with FKBP1B and Disease Models, Animal

Organs/Tissues associated with anti-FKBP1B antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with FKBP1B and Muscle
 Brain Antibodies  >2 publications with FKBP1B and Brain
 Blood Antibodies  >1 publications with FKBP1B and Blood
 Eye Antibodies  >1 publications with FKBP1B and Eye
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