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FREM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243483

MBS243483 is an antibody targeting FREM2. Also known as Rabbit Polyclonal to Human FREM2. Reactive in Human, Mouse. Host: Rabbit. More details

$750 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FREM2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human FREM2
Product Gene Name
anti-FREM2 antibody
Product Synonym Names
Anti-FREM2 Antibody (Internal) IHC-plus; FREM2; ECM3 homolog; Human FREM2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human FREM2
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
295,845 Da
OMIM
phenotype 608945
3D Structure
ModBase 3D Structure for Q5SZK8
Target Species
Human
Immunogen Description
A 19 amino acid peptide near the center of human FREM2.
Immunogen Type
Synthetic peptide
Immunogen
FREM2 antibody was raised against a 19 amino acid peptide near the center of human FREM2.
Antigen Modification
Internal
Applications Tested/Suitable for anti-FREM2 antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB), ELISA (EIA)
Application Notes for anti-FREM2 antibody
ELISA, ICC, IHC-P (5 ug/ml), WB
Usage: FREM2 antibody was raised against a 19 amino acid peptide near the center of human FREM2.

Immunohistochemistry (IHC) of anti-FREM2 antibody

Anti-FREM2 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-FREM2 Polyclonal Antibody – Cat# MBS243483

Immunohistochemistry (IHC) of anti-FREM2 antibody

Anti-FREM2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-FREM2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243483

Immunofluorescence (IF) of anti-FREM2 antibody

Immunofluorescence of FREM2 in A20 cells with FREM2 antibody at 20 ug/ml.
Rabbit Anti-FREM2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS243483

Immunocytochemistry (ICC) of anti-FREM2 antibody

Immunocytochemistry of FREM2 in A-20 cells with FREM2 antibody at 20 ug/ml.
Rabbit Anti-FREM2 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS243483

Western Blot (WB) of anti-FREM2 antibody

Western blot analysis of FREM2 in A-20 cell lysate with FREM2 antibody at (A) 0.5 and (B) 1ug/ml.
Rabbit Anti-FREM2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS243483

Other Notes

Small volumes of anti-FREM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FREM2. It may not necessarily be applicable to this product.

NCBI GI #
79749430
NCBI GeneID
341640
NCBI Accession #
NP_997244.3
UniProt Primary Accession #
Q5SZK8
UniProt Secondary Accession #
Q4QQG1; Q5H9N8; Q5T6Q1; Q6N057; Q6ZSB4; Q7Z305; Q7Z341
UniProt Related Accession #
Q5SZK8
GenBank Nucleotide #
NM_207361.4
NCBI Official Full Name
FRAS1-related extracellular matrix protein 2
NCBI Official Synonym Full Names
FRAS1 related extracellular matrix protein 2
NCBI Official Symbol
FREM2
UniProt Protein Name
FRAS1-related extracellular matrix protein 2
UniProt Synonym Protein Names
ECM3 homolog
Protein Family
FRAS1-related extracellular matrix protein
UniProt Gene Name
FREM2
UniProt Entry Name
FREM2_HUMAN
NCBI Protein Information
FRAS1-related extracellular matrix protein 2; ECM3 homolog

NCBI Summary for FREM2

This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014]
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UniProt Comments for FREM2

FREM2: Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion. Defects in FREM2 are a cause of Fraser syndrome (FRASS). Fraser syndrome is a multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects. Belongs to the FRAS1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Extracellular matrix

Chromosomal Location of Human Ortholog: 13q13.3

Cellular Component: integral to membrane; plasma membrane; basement membrane

Molecular Function: calcium ion binding

Biological Process: morphogenesis of an epithelium; cell communication; homophilic cell adhesion; inner ear development

Disease: Fraser Syndrome
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Research Articles on FREM2

1. In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FREM2 antibody

 Reference Product  PubMed Publications
 GRIP1 antibody  >8 publications with FREM2 and GRIP1

Diseases associated with anti-FREM2 antibody

 Disease Name  Pubmed Publications
 Fraser Syndrome Antibodies  >30 publications with FREM2 and Fraser Syndrome
 Congenital Abnormalities Antibodies  >22 publications with FREM2 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >17 publications with FREM2 and Abnormalities, Multiple
 Eye Abnormalities Antibodies  >13 publications with FREM2 and Eye Abnormalities
 Disease Models, Animal Antibodies  >6 publications with FREM2 and Disease Models, Animal
 Kidney Diseases Antibodies  >5 publications with FREM2 and Kidney Diseases
 Skin Diseases Antibodies  >3 publications with FREM2 and Skin Diseases
 Craniofacial Abnormalities Antibodies  >2 publications with FREM2 and Craniofacial Abnormalities
 Nervous System Malformations Antibodies  >2 publications with FREM2 and Nervous System Malformations
 Nervous System Diseases Antibodies  >2 publications with FREM2 and Nervous System Diseases

Organs/Tissues associated with anti-FREM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >14 publications with FREM2 and Embryonic Tissue
 Nerve Antibodies  >7 publications with FREM2 and Nerve
 Kidney Antibodies  >6 publications with FREM2 and Kidney
 Brain Antibodies  >3 publications with FREM2 and Brain
 Lung Antibodies  >2 publications with FREM2 and Lung
 Uterus Antibodies  >1 publications with FREM2 and Uterus
 Mouth Antibodies  >1 publications with FREM2 and Mouth
 Intestine Antibodies  >1 publications with FREM2 and Intestine
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