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HMGA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9215082

Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. More details

$240 / 0.08 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Hmga2, Polyclonal Antibody
Full Product Name
Mouse Hmga2 Antibody (N-term)
Product Gene Name
anti-Hmga2 antibody
Product Synonym Names
High mobility group protein HMGI-C; High mobility group AT-hook protein 2; Hmga2; Hmgic
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This Mouse Hmga2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 26-59 amino acids from the N-terminal region of Mouse Hmga2.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
Hmga2 peptide (MBS9229659) is used for blocking the activity of Hmga2 antibody (MBS9215082)
Molecular Weight
11819
3D Structure
ModBase 3D Structure for P52927
Crown Antibody
Yes
Antigen Source
HUMAN

Product Categories/Family for anti-Hmga2 antibody

Crown Antibodies; Cancer; Developmental Biology; Neuroscience; Stem Cells
Applications Tested/Suitable for anti-Hmga2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-Hmga2 antibody
WB~~1:1000

Western Blot (WB) of anti-Hmga2 antibody

Western blot analysis of lysates from HepG2, mouse NIH/3T3 cell line (from left to right), using Mouse Hmga2 Antibody (N-term). MBS9215082 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
Rabbit Anti-HMGA2 Polyclonal Antibody – Cat# MBS9215082

Western Blot (WB) of anti-Hmga2 antibody

Western blot analysis of lysate from NCCIT cell line, using Mouse Hmga2 Antibody (N-term). MBS9215082 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
Rabbit Anti-HMGA2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9215082

Product References and Citations for anti-Hmga2 antibody

Manfioletti G.,et al.Nucleic Acids Res. 19:6793-6797(1991).
Manfioletti G.,et al.Gene 167:249-253(1995).
Zhou X.,et al.Nucleic Acids Res. 24:4071-4077(1996).
Carninci P.,et al.Science 309:1559-1563(2005).
Di Agostino S.,et al.Mol. Biol. Cell 15:1224-1232(2004).

Other Notes

Small volumes of anti-Hmga2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hmga2 purchase

MBS9215082 is an antibody targeting Hmga2. Also known as Mouse Hmga2 Antibody (N-term). Reactive in Human, mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Hmga2. It may not necessarily be applicable to this product.

NCBI GI #
6754210
NCBI GeneID
15364
NCBI Accession #
NP_034571.1
UniProt Primary Accession #
P52927
UniProt Secondary Accession #
Q3UQW0
UniProt Related Accession #
P52927
GenBank Nucleotide #
NM_010441.2
NCBI Official Full Name
high mobility group protein HMGI-C
NCBI Official Synonym Full Names
high mobility group AT-hook 2
NCBI Official Symbol
Hmga2
NCBI Official Synonym Symbols
pg; Hmgic; pygmy; HMGI-C; 9430083A20Rik
UniProt Protein Name
High mobility group protein HMGI-C
UniProt Synonym Protein Names
High mobility group AT-hook protein 2
Protein Family
High mobility group protein
UniProt Gene Name
Hmga2
UniProt Synonym Gene Names
Hmgic
UniProt Entry Name
HMGA2_MOUSE
NCBI Protein Information
high mobility group protein HMGI-C

UniProt Comments for Hmga2

HMGA2: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; DNA-binding

Cellular Component: nuclear chromosome; chromatin; nucleus

Molecular Function: protein binding; enzyme binding; DNA-(apurinic or apyrimidinic site) lyase activity; DNA binding; AT DNA binding

Biological Process: transcription from RNA polymerase II promoter; somatic stem cell maintenance; cell proliferation in forebrain; positive regulation of multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; signal transduction; regulation of growth hormone secretion; meiotic cell cycle; regulation of transcription, DNA-dependent; base-excision repair; regulation of growth; positive regulation of cell proliferation; mitosis; negative regulation of steroid hormone receptor signaling pathway; transcription, DNA-dependent; adrenal gland development; male gonad development; cell cycle; DNA catabolic process, endonucleolytic; chromosome condensation; cell proliferation; cell division; pituitary gland development; negative regulation of astrocyte differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; negative regulation of JAK-STAT cascade
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Research Articles on Hmga2

1. Hmga2 is a transcriptional target of RUNX1 and a critical regulator of myeloid progenitor expansion

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Hmga2 antibody

 Reference Product  PubMed Publications
 Hmga1 antibody  >192 publications with Hmga2 and Hmga1
 Trp53 antibody  >14 publications with Hmga2 and Trp53
 Rb1 antibody  >7 publications with Hmga2 and Rb1
 Snai1 antibody  >4 publications with Hmga2 and Snai1
 Snai2 antibody  >1 publications with Hmga2 and Snai2

Pathways associated with anti-Hmga2 antibody

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Diseases associated with anti-Hmga2 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >136 publications with Hmga2 and Carcinoma
 LIPOMATOSIS, MULTIPLE Antibodies  >96 publications with Hmga2 and LIPOMATOSIS, MULTIPLE
 Adenocarcinoma Antibodies  >71 publications with Hmga2 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >70 publications with Hmga2 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >43 publications with Hmga2 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >35 publications with Hmga2 and Neoplasm Metastasis
 Skin Diseases Antibodies  >33 publications with Hmga2 and Skin Diseases
 Hematologic Diseases Antibodies  >33 publications with Hmga2 and Hematologic Diseases
 Nervous System Diseases Antibodies  >32 publications with Hmga2 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >32 publications with Hmga2 and Neoplasms, Experimental

Organs/Tissues associated with anti-Hmga2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >65 publications with Hmga2 and Lung
 Muscle Antibodies  >61 publications with Hmga2 and Muscle
 Embryonic Tissue Antibodies  >46 publications with Hmga2 and Embryonic Tissue
 Brain Antibodies  >23 publications with Hmga2 and Brain
 Connective Tissue Antibodies  >22 publications with Hmga2 and Connective Tissue
 Heart Antibodies  >18 publications with Hmga2 and Heart
 Liver Antibodies  >18 publications with Hmga2 and Liver
 Bone Marrow Antibodies  >16 publications with Hmga2 and Bone Marrow
 Skin Antibodies  >13 publications with Hmga2 and Skin
 Eye Antibodies  >13 publications with Hmga2 and Eye
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