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HPD Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6481136

MBS6481136 is an antibody targeting HPD. Also known as HPD, CT (4-Hydroxyphenylpyruvate Dioxygenase, 4-hydroxyphenylpyruvic Acid Oxidase, 4HPPD, 4-HPPD, HPPDase, GLOD3, PPD) (MaxLight 550). Reactive in Human, Mouse. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HPD, Polyclonal Antibody
Full Product Name
HPD, CT (4-Hydroxyphenylpyruvate Dioxygenase, 4-hydroxyphenylpyruvic Acid Oxidase, 4HPPD, 4-HPPD, HPPDase, GLOD3, PPD) (MaxLight 550)
Product Gene Name
anti-HPD antibody
Product Synonym Names
EC=1.13.11.27
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human HPD. Species Crossreactivity: mouse
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
44.934
OMIM
phenotype 609695
3D Structure
ModBase 3D Structure for P32754
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 255-284 in the C-terminal region of human HPD.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-HPD antibody

Antibodies; Enzymes; Oxidase
Applications Tested/Suitable for anti-HPD antibody
Immunohistochemistry (IHC) Paraffin, FLISA, Western Blot (WB)
Application Notes for anti-HPD antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-HPD antibody

Western Blot analysis in mouse liver tissue lysates (35ug/lane) usingMBS646009. HPD (arrow) was detected usingMBS646009.
Rabbit Anti-HPD Polyclonal Antibody – Cat# MBS6481136

Immunohistochemistry (IHC) of anti-HPD antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human hepatocarcinoma reacted withMBS646009, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of MBS646009 for immunohistochemistry.
Rabbit Anti-HPD Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6481136

Product References and Citations for anti-HPD antibody

1. Item, C.B., et.al., Mol. Genet. Metab. 91(4), 379-383 (2007). 2. Wistow, G., et.al., Mol. Vis. 8, 171-184 (2002).

Other Notes

Small volumes of anti-HPD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HPD. It may not necessarily be applicable to this product.

NCBI GI #
4504477
NCBI GeneID
3242
NCBI Accession #
NP_002141.1
UniProt Primary Accession #
P32754
UniProt Related Accession #
P32754
GenBank Nucleotide #
NP_002141.1
NCBI Official Full Name
4-hydroxyphenylpyruvate dioxygenase isoform 1
NCBI Official Synonym Full Names
4-hydroxyphenylpyruvate dioxygenase
NCBI Official Symbol
HPD
NCBI Official Synonym Symbols
PPD; 4HPPD; GLOD3; 4-HPPD; HPPDASE
UniProt Protein Name
4-hydroxyphenylpyruvate dioxygenase
UniProt Synonym Protein Names
4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase
Protein Family
Probable 4-hydroxyphenylpyruvate dioxygenase
UniProt Gene Name
HPD
UniProt Synonym Gene Names
PPD; 4HPPD; HPD; HPPDase
UniProt Entry Name
HPPD_HUMAN
NCBI Protein Information
4-hydroxyphenylpyruvate dioxygenase

NCBI Summary for HPD

The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
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UniProt Comments for HPD

HPD: Key enzyme in the degradation of tyrosine. Defects in HPD are the cause of tyrosinemia type 3 (TYRO3). TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. Defects in HPD are a cause of hawkinsinuria (HAWK). HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. Belongs to the 4HPPD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.13.11.27; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; Amino Acid Metabolism - phenylalanine; Oxidoreductase; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: cytosol

Molecular Function: 4-hydroxyphenylpyruvate dioxygenase activity; metal ion binding

Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process

Disease: Hawkinsinuria; Tyrosinemia, Type Iii
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Research Articles on HPD

1. Our findings indicate that HPD may be a useful prognostic predictor, and a potential therapeutic target for patients with breast cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HPD antibody

 Reference Product  PubMed Publications
 FAH antibody  >8 publications with HPD and FAH
 HGD antibody  >2 publications with HPD and HGD

Pathways associated with anti-HPD antibody

 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Phenylalanine And Tyrosine Catabolism Pathway antibodies  Phenylalanine And Tyrosine Catabolism Pathway Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram
 Tyrosine Degradation, Tyrosine => Homogentisate Pathway antibodies  Tyrosine Degradation, Tyrosine => Homogentisate Pathway Diagram
 Tyrosine Degradation, Tyrosine => Homogentisate Pathway antibodies  Tyrosine Degradation, Tyrosine => Homogentisate Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram

Diseases associated with anti-HPD antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >92 publications with HPD and Brain Diseases
 Necrosis Antibodies  >81 publications with HPD and Necrosis
 Lung Neoplasms Antibodies  >63 publications with HPD and Lung Neoplasms
 Lung Diseases Antibodies  >55 publications with HPD and Lung Diseases
 Liver Neoplasms Antibodies  >52 publications with HPD and Liver Neoplasms
 Urinary Bladder Neoplasms Antibodies  >49 publications with HPD and Urinary Bladder Neoplasms
 Liver Diseases Antibodies  >42 publications with HPD and Liver Diseases
 Kidney Diseases Antibodies  >37 publications with HPD and Kidney Diseases
 Liver Neoplasms, Experimental Antibodies  >23 publications with HPD and Liver Neoplasms, Experimental
 Heart Diseases Antibodies  >20 publications with HPD and Heart Diseases

Organs/Tissues associated with anti-HPD antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >226 publications with HPD and Brain
 Liver Antibodies  >126 publications with HPD and Liver
 Kidney Antibodies  >73 publications with HPD and Kidney
 Lung Antibodies  >71 publications with HPD and Lung
 Eye Antibodies  >33 publications with HPD and Eye
 Lymph Antibodies  >20 publications with HPD and Lymph
 Testis Antibodies  >9 publications with HPD and Testis
 Cervix Antibodies  >5 publications with HPD and Cervix
 Mammary Gland Antibodies  >1 publications with HPD and Mammary Gland
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