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hPFTK1-M1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6308226

MBS6308226 is an antibody targeting hPFTK1-M1. Also known as hPFTK1-M1 (CDK14, KIAA0834, PFTK1, Cyclin-dependent kinase 14, Cell division protein kinase 14, Serine/threonine-protein kinase PFTAIRE-1) (MaxLight 405). Reactive in Human, Mouse. Host: Rabbit.… More details

$1025 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
hPFTK1-M1, Polyclonal Antibody
Full Product Name
hPFTK1-M1 (CDK14, KIAA0834, PFTK1, Cyclin-dependent kinase 14, Cell division protein kinase 14, Serine/threonine-protein kinase PFTAIRE-1) (MaxLight 405)
Product Gene Name
anti-hPFTK1-M1 antibody
Product Synonym Gene Name
CDK14
Product Synonym Names
CDK14; KIAA0834; PFTK1; Cyclin-dependent kinase 14; Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
47,760 Da
OMIM
610679
3D Structure
ModBase 3D Structure for O94921
Immunogen
hPFTK1-M1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from M1 region of human PFTK1.
Conjugate
MaxLight405
Note
Preservative Free

Product Categories/Family for anti-hPFTK1-M1 antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-hPFTK1-M1 antibody
Western Blot (WB), FLISA
Application Notes for anti-hPFTK1-M1 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-hPFTK1-M1 antibody

Malumbres, M., et al. Nat. Cell Biol. 11(11):1275-1276(2009). Jiang, M., et al. FEBS Lett. 583(13):2171-2178(2009). de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009). Denoeud, F., et al. Genome Res. 17(6):746-759(2007). Shu, F., et al. Proc. Natl. Acad. Sci. U.S.A. 104(22):9248-9253(2007).

Other Notes

Small volumes of anti-hPFTK1-M1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for hPFTK1-M1. It may not necessarily be applicable to this product.

NCBI GI #
6912584
NCBI GeneID
5218
NCBI Accession #
NP_036527
UniProt Primary Accession #
O94921
UniProt Secondary Accession #
Q75N06; Q75N22; Q8N764; Q9H3D7; Q9UDR0; A4D1E6; A6NK51; A8WFP6; B4DHG5; B4DNM2
UniProt Related Accession #
O94921
GenBank Nucleotide #
NM_012395.3
NCBI Official Full Name
cyclin-dependent kinase 14 isoform b
NCBI Official Synonym Full Names
cyclin dependent kinase 14
NCBI Official Symbol
CDK14
NCBI Official Synonym Symbols
PFTK1; PFTAIRE1
UniProt Protein Name
Cyclin-dependent kinase 14
UniProt Synonym Protein Names
Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1; hPFTAIRE1
UniProt Gene Name
CDK14
UniProt Synonym Gene Names
KIAA0834; PFTK1; hPFTAIRE1
UniProt Entry Name
CDK14_HUMAN
NCBI Protein Information
cyclin-dependent kinase 14

NCBI Summary for hPFTK1-M1

PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]

UniProt Comments for hPFTK1-M1

CDK14: a protein kinase of the CDK family. May play a role in meiosis as well as in neuron differentiation and/or function. Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Two alternatively spliced isoforms have been described.

Protein type: Cell cycle regulation; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.22; Motility/polarity/chemotaxis; Kinase, protein; CMGC group; CDK family; CDK/TAIRE subfamily; TAIRE subfamily

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: cytoplasm; plasma membrane; cytosol; nucleus

Molecular Function: protein binding; cyclin binding; cyclin-dependent protein kinase activity; ATP binding

Biological Process: Wnt receptor signaling pathway; regulation of cell cycle; cell division; G2/M transition of mitotic cell cycle; protein amino acid phosphorylation
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Research Articles on hPFTK1-M1

1. PFTK1 overexpression promoted proliferation, migration and invasion of gastric cancer cells, while PFTK1 knockdown led to the opposite results.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-hPFTK1-M1 antibody

 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with anti-hPFTK1-M1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >7 publications with hPFTK1-M1 and Adenocarcinoma
 Liver Neoplasms Antibodies  >6 publications with hPFTK1-M1 and Liver Neoplasms
 Liver Diseases Antibodies  >6 publications with hPFTK1-M1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >6 publications with hPFTK1-M1 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-hPFTK1-M1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with hPFTK1-M1 and Liver
 Lung Antibodies  >2 publications with hPFTK1-M1 and Lung
 Brain Antibodies  >2 publications with hPFTK1-M1 and Brain
 Bone Antibodies  >1 publications with hPFTK1-M1 and Bone
 Testis Antibodies  >1 publications with hPFTK1-M1 and Testis
 Muscle Antibodies  >1 publications with hPFTK1-M1 and Muscle
 Vascular Antibodies  >1 publications with hPFTK1-M1 and Vascular
 Blood Antibodies  >1 publications with hPFTK1-M1 and Blood
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