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ICK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9409751

May play a key role in the development of multiple organ systems and particularly in cardiac development By similarity.Togawa K.,J. Cell. Physiol. 183:129-139(2000).Yang T.,Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.Nagase T.,DNA Res.… More details

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Product Overview

Online Datasheet in PDF
Product Name
ICK, Polyclonal Antibody
Full Product Name
ICK (Ab-159) Antibody
Product Gene Name
anti-ICK antibody
Product Synonym Names
EC 2.7.11.22; hICK; ICK; Intestinal cell kinase; KIAA0936
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total ICK protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
34,071 Da
OMIM
612325
3D Structure
ModBase 3D Structure for Q9UPZ9
Immunogen Type
Peptide
Immunogen Description
Synthesized non-phosphopeptide derived from human ICK around the phosphorylation site of tyrosine 159 (T-D-Y(p)-V-S).
Target Name
ICK

Product Categories/Family for anti-ICK antibody

Total protein Ab
Applications Tested/Suitable for anti-ICK antibody
Western Blot (WB)
Application Notes for anti-ICK antibody
Western blotting: 1:500~1:3000

Western Blot (WB) of anti-ICK antibody

Western blot analysis of extracts from 3T3 cells, treated with PBS (10uM, 60mins), using ICK (Ab-159) antibody.
Rabbit Anti-ICK Polyclonal Antibody – Cat# MBS9409751

Western Blot (WB) of anti-ICK antibody

Western blot analysis of extracts from 293 cells (Lane 2) and cos-7 cells (Lane 3), using ICK (Ab-159) antiobdy. The lane on the left is treated with synthesized peptide.
Rabbit Anti-ICK Polyclonal Antibody, Western Blot (WB) – Cat# MBS9409751

Other Notes

Small volumes of anti-ICK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ICK purchase

MBS9409751 is an antibody targeting ICK. Also known as ICK (Ab-159) Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ICK. It may not necessarily be applicable to this product.

NCBI GI #
7662388
NCBI GeneID
22858
NCBI Accession #
NP_055735.1
UniProt Primary Accession #
Q9UPZ9
UniProt Secondary Accession #
O75985; Q5THL2; Q8IYH8; Q9BX17; Q9NYX3; A7MD41
UniProt Related Accession #
Q9UPZ9
GenBank Nucleotide #
NM_014920.3
NCBI Official Full Name
serine/threonine-protein kinase ICK
NCBI Official Synonym Full Names
intestinal cell (MAK-like) kinase
NCBI Official Symbol
ICK
NCBI Official Synonym Symbols
ECO; MRK; LCK2
UniProt Protein Name
Serine/threonine-protein kinase ICK
UniProt Synonym Protein Names
Intestinal cell kinase; hICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
ICK
UniProt Synonym Gene Names
KIAA0936; hICK; LCK2; MRK
UniProt Entry Name
ICK_HUMAN
NCBI Protein Information
serine/threonine-protein kinase ICK

NCBI Summary for ICK

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]
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UniProt Comments for ICK

ICK: a CMGC kinase of the RCK family. May play a role in cardiac development. Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Also expressed in many cancer cell lines. Two alternatively spliced isoforms have been described.

Protein type: EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Kinase, protein; CMGC group; RCK family

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; cyclin-dependent protein kinase activity; magnesium ion binding; ATP binding

Biological Process: regulation of cell cycle; multicellular organismal development; intraflagellar transport; cilium biogenesis; signal transduction; protein amino acid phosphorylation

Disease: Endocrine-cerebroosteodysplasia
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Research Articles on ICK

1. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ICK antibody

 Reference Product  PubMed Publications
 RPTOR antibody  >2 publications with ICK and RPTOR
 MAPK1 antibody  >1 publications with ICK and MAPK1

Diseases associated with anti-ICK antibody

 Disease Name  Pubmed Publications
 Lymphatic Diseases Antibodies  >6 publications with ICK and Lymphatic Diseases
 Inflammation Antibodies  >4 publications with ICK and Inflammation
 Breast Neoplasms Antibodies  >3 publications with ICK and Breast Neoplasms
 Poisoning Antibodies  >2 publications with ICK and Poisoning
 Mental Disorders Antibodies  >2 publications with ICK and Mental Disorders
 Liver Diseases Antibodies  >2 publications with ICK and Liver Diseases
 Congenital Abnormalities Antibodies  >2 publications with ICK and Congenital Abnormalities
 Cell Transformation, Neoplastic Antibodies  >2 publications with ICK and Cell Transformation, Neoplastic
 Atrophy Antibodies  >1 publications with ICK and Atrophy
 Urinary Bladder Neoplasms Antibodies  >1 publications with ICK and Urinary Bladder Neoplasms

Organs/Tissues associated with anti-ICK antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >16 publications with ICK and Eye
 Brain Antibodies  >11 publications with ICK and Brain
 Liver Antibodies  >8 publications with ICK and Liver
 Intestine Antibodies  >7 publications with ICK and Intestine
 Muscle Antibodies  >6 publications with ICK and Muscle
 Bone Antibodies  >5 publications with ICK and Bone
 Vascular Antibodies  >4 publications with ICK and Vascular
 Skin Antibodies  >4 publications with ICK and Skin
 Kidney Antibodies  >3 publications with ICK and Kidney
 Prostate Antibodies  >2 publications with ICK and Prostate
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