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IGFALS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630019

IGFALS is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this protein are a… More details

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Product Overview

Online Datasheet in PDF
Product Name
IGFALS, Polyclonal Antibody
Full Product Name
IGFALS (Insulin-like Growth Factor Binding Protein Complex Acid Labile Subunit, ALS)
Product Gene Name
anti-IGFALS antibody
Product Synonym Names
Anti -IGFALS (Insulin-like Growth Factor Binding Protein Complex Acid Labile Subunit, ALS)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human IGFALS. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
66,035 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (1840414..1844909, complement). Location: 16p13.3
OMIM
601489
3D Structure
ModBase 3D Structure for P35858
Immunogen
Synthetic peptide selected from the Center region of human IGFALS (KLH).

Product Categories/Family for anti-IGFALS antibody

Antibodies; Abs to Serum Proteins
Applications Tested/Suitable for anti-IGFALS antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-IGFALS antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-IGFALS antibody

Western blot analysis in mouse spleen tissue, Jurkat cell line and mouse liver tissue lysates (35ug/lane) using MBS630019. IGFALS (arrow) was detected using MBS630019.
Rabbit Anti-IGFALS Polyclonal Antibody – Cat# MBS630019

Immunohistochemistry (IHC) of anti-IGFALS antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with MBS630019 (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry.
Rabbit Anti-IGFALS Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS630019

Flow Cytometry (FC/FACS) of anti-IGFALS antibody

Flow cytometry analysis of Jurkat cells (bottom histogram) using MBS630019 compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-IGFALS Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS630019

Other Notes

Small volumes of anti-IGFALS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IGFALS purchase

MBS630019 is an antibody targeting IGFALS. Also known as IGFALS (Insulin-like Growth Factor Binding Protein Complex Acid Labile Subunit, ALS). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IGFALS. It may not necessarily be applicable to this product.

NCBI GI #
4826772
NCBI GeneID
3483
NCBI Accession #
NP_004961.1
UniProt Primary Accession #
P35858
UniProt Secondary Accession #
B4DZY8; E9PGU3
UniProt Related Accession #
P35858
GenBank Nucleotide #
NM_004970.2
NCBI Official Full Name
insulin-like growth factor-binding protein complex acid labile subunit isoform 2
NCBI Official Synonym Full Names
insulin-like growth factor binding protein, acid labile subunit
NCBI Official Symbol
IGFALS
NCBI Official Synonym Symbols
ALS
UniProt Protein Name
Insulin-like growth factor-binding protein complex acid labile subunit
Protein Family
Insulin-like growth factor-binding protein complex acid labile
UniProt Gene Name
IGFALS
UniProt Synonym Gene Names
ALS; ALS
UniProt Entry Name
ALS_HUMAN
NCBI Protein Information
insulin-like growth factor-binding protein complex acid labile subunit; insulin-like growth factor binding protein complex acid labile chain

NCBI Summary for IGFALS

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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UniProt Comments for IGFALS

IGFALS: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.

Protein type: Secreted; Secreted, signal peptide; Cell adhesion

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: nucleoplasm; extracellular space; extracellular region

Molecular Function: insulin-like growth factor binding

Biological Process: cellular protein metabolic process; signal transduction; cell adhesion

Disease: Acid-labile Subunit Deficiency
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Research Articles on IGFALS

1. functional analysis supported a tumor-suppressive function for IGFALS in vitro.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IGFALS antibody

 Reference Product  PubMed Publications
 IGF1 antibody  >19 publications with IGFALS and IGF1
 IGFBP3 antibody  >16 publications with IGFALS and IGFBP3
 IGF2 antibody  >3 publications with IGFALS and IGF2

Pathways associated with anti-IGFALS antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram

Diseases associated with anti-IGFALS antibody

 Disease Name  Pubmed Publications
 Growth Disorders Antibodies  >15 publications with IGFALS and Growth Disorders
 Insulin Resistance Antibodies  >9 publications with IGFALS and Insulin Resistance
 Puberty, Delayed Antibodies  >4 publications with IGFALS and Puberty, Delayed
 Heart Diseases Antibodies  >2 publications with IGFALS and Heart Diseases
 Liver Diseases Antibodies  >2 publications with IGFALS and Liver Diseases
 Atrophy Antibodies  >2 publications with IGFALS and Atrophy
 Weight Loss Antibodies  >1 publications with IGFALS and Weight Loss
 Inflammation Antibodies  >1 publications with IGFALS and Inflammation
 Carcinoma, Hepatocellular Antibodies  >1 publications with IGFALS and Carcinoma, Hepatocellular
 Fatty Liver Antibodies  >1 publications with IGFALS and Fatty Liver

Organs/Tissues associated with anti-IGFALS antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with IGFALS and Liver
 Eye Antibodies  >1 publications with IGFALS and Eye
 Brain Antibodies  >1 publications with IGFALS and Brain
 Mammary Gland Antibodies  >1 publications with IGFALS and Mammary Gland
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