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IGSF1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6309580

MBS6309580 is an antibody targeting IGSF1. Also known as IGSF1, CT (IGSF1, IGDC1, KIAA0364, PGSF2, Immunoglobulin superfamily member 1, Immunoglobulin-like domain-containing protein 1, Inhibin-binding protein, Pituitary gland-specific factor 2, p120)… More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IGSF1, Polyclonal Antibody
Full Product Name
IGSF1, CT (IGSF1, IGDC1, KIAA0364, PGSF2, Immunoglobulin superfamily member 1, Immunoglobulin-like domain-containing protein 1, Inhibin-binding protein, Pituitary gland-specific factor 2, p120) (MaxLight 490)
Product Gene Name
anti-IGSF1 antibody
Product Synonym Names
IGSF1; IGDC1; KIAA0364; PGSF2; Immunoglobulin superfamily member 1; Immunoglobulin-like domain-containing protein 1; Inhibin-binding protein; Pituitary gland-specific factor 2; p120
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human IGSF1. Species Crossreactivity: mouse
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
300137
3D Structure
ModBase 3D Structure for Q8N6C5
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1270-1297 in the C-terminal region of human IGSF1, UniProt Accession #Q8N6C5. Species sequence homology: rat
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-IGSF1 antibody

Antibodies; Binding Proteins
Applications Tested/Suitable for anti-IGSF1 antibody
Immunohistochemistry (IHC) Paraffin, FLISA, Western Blot (WB)
Application Notes for anti-IGSF1 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-IGSF1 antibody

Western Blot analysis in mouse kidney tissue lysates (35ug/lane) usingMBS6001603. This demonstrates that MBS6001603 detected the IGSF1 protein (arrow).
Rabbit Anti-IGSF1 Polyclonal Antibody – Cat# MBS6309580

Immunohistochemistry (IHC) of anti-IGSF1 antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma using MBS6001603 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6001603 for immunohistochemistry.
Rabbit Anti-IGSF1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6309580

Product References and Citations for anti-IGSF1 antibody

1. Robakis, T., et al. J. Biol. Chem. 283(52):36369-36376(2008). 2. Nakayama, M., et al. Genome Res. 12(11):1773-1784(2002). 3. Tanaka, S., et al. J. Mol. Endocrinol. 28(1):33-44(2002). 4. Gui, Y., et al. J. Clin. Endocrinol. Metab. 86(5):2104-2110(2001). 5. Chapman, S.C., et al. Mol. Endocrinol. 15(4):668-679(2001).

Other Notes

Small volumes of anti-IGSF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IGSF1. It may not necessarily be applicable to this product.

NCBI GI #
283436133
NCBI GeneID
3547
NCBI Accession #
NP_001164433.1
UniProt Primary Accession #
Q8N6C5
UniProt Related Accession #
Q8N6C5
GenBank Nucleotide #
NP_001164433.1
NCBI Official Full Name
immunoglobulin superfamily member 1 isoform 4
NCBI Official Synonym Full Names
immunoglobulin superfamily member 1
NCBI Official Symbol
IGSF1
NCBI Official Synonym Symbols
CHTE; p120; IGCD1; IGDC1; INHBP; PGSF2
UniProt Protein Name
Immunoglobulin superfamily member 1
UniProt Synonym Protein Names
Immunoglobulin-like domain-containing protein 1; Inhibin-binding protein; InhBP; Pituitary gland-specific factor 2; p120
Protein Family
Immunoglobulin superfamily
UniProt Gene Name
IGSF1
UniProt Synonym Gene Names
IGDC1; KIAA0364; PGSF2; IgSF1; InhBP
UniProt Entry Name
IGSF1_HUMAN
NCBI Protein Information
immunoglobulin superfamily member 1

NCBI Summary for IGSF1

This gene encodes a member of the immunoglobulin-like domain-containing superfamily. Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
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UniProt Comments for IGSF1

IGSF1: Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B. Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: membrane; integral to membrane; extracellular region

Molecular Function: protein binding; coreceptor activity; receptor activity

Biological Process: regulation of transcription, DNA-dependent; signal transduction

Disease: Hypothyroidism, Central, And Testicular Enlargement
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Research Articles on IGSF1

1. somatotrope neurosecretory hyperfunction in IGSF1-deficient humans and mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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