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IL17B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6309930

The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of… More details

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Product Overview

Online Datasheet in PDF
Product Name
IL17B, Polyclonal Antibody
Full Product Name
IL17B, ID (IL17B, IL20, NIRF, ZCYTO7, Interleukin-17B, Cytokine Zcyto7, Interleukin-20, Neuronal interleukin-17-related factor) (Azide free) (HRP)
Product Gene Name
anti-IL17B antibody
Product Synonym Names
IL17B; IL20; NIRF; ZCYTO7; Interleukin-17B; Cytokine Zcyto7; Interleukin-20; Neuronal interleukin-17-related factor
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
20,437 Da
OMIM
604627
3D Structure
ModBase 3D Structure for Q9UHF5
Immunogen
IL17B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the Central region of human IL17B.
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-IL17B antibody

Antibodies; Interleukin
Applications Tested/Suitable for anti-IL17B antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-IL17B antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-IL17B antibody

IL17B Antibody (Center) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the IL17B antibody detected the IL17B protein (arrow).
Rabbit Anti-IL17B Polyclonal Antibody – Cat# MBS6309930

Western Blot (WB) of anti-IL17B antibody

Western blot analysis of IL17B (arrow) using rabbit polyclonal IL17B Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the IL17B gene.
Rabbit Anti-IL17B Polyclonal Antibody, Western Blot (WB) – Cat# MBS6309930

Immunohistochemistry (IHC) of anti-IL17B antibody

IL17B Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IL17B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-IL17B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6309930

Immunofluorescence (IF) of anti-IL17B antibody

Confocal immunofluorescent analysis of IL17B Antibody (Center) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-IL17B Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6309930

Product References and Citations for anti-IL17B antibody

Koskinen, L.L., et al. Tissue Antigens 74(5):408-416(2009). Wang, X., et al. Ann. Otol. Rhinol. Laryngol. 115(6):450-456(2006). Ryan, A.W., et al. Tissue Antigens 65(2):150-155(2005). Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003). Moore, E.E., et al. Neuromuscul. Disord. 12(2):141-150(2002).

Other Notes

Small volumes of anti-IL17B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL17B purchase

MBS6309930 is an antibody targeting IL17B. Also known as IL17B, ID (IL17B, IL20, NIRF, ZCYTO7, Interleukin-17B, Cytokine Zcyto7, Interleukin-20, Neuronal interleukin-17-related factor) (Azide free) (HRP). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL17B. It may not necessarily be applicable to this product.

NCBI GI #
7657228
NCBI GeneID
27190
NCBI Accession #
NP_055258.1
UniProt Primary Accession #
Q9UHF5
UniProt Secondary Accession #
Q14CE5
UniProt Related Accession #
Q9UHF5
GenBank Nucleotide #
NM_014443.2
NCBI Official Full Name
interleukin-17B
NCBI Official Synonym Full Names
interleukin 17B
NCBI Official Symbol
IL17B
NCBI Official Synonym Symbols
NIRF; IL-20; IL-17B; ZCYTO7
UniProt Protein Name
Interleukin-17B
UniProt Synonym Protein Names
Cytokine Zcyto7; Interleukin-20; IL-20; Neuronal interleukin-17-related factor
Protein Family
Interleukin
UniProt Gene Name
IL17B
UniProt Synonym Gene Names
IL20; NIRF; ZCYTO7; IL-17B; IL-20
UniProt Entry Name
IL17B_HUMAN
NCBI Protein Information
interleukin-17B; cytokine Zcyto7; cytokine-like protein ZCYTO7; interleukin 20; interleukin-17 beta; interleukin-20; neuronal interleukin-17 related factor; neuronal interleukin-17-related factor

UniProt Comments for IL17B

IL17B: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. Belongs to the IL-17 family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: extracellular space

Molecular Function: cytokine activity

Biological Process: cell-cell signaling; immune response; inflammatory response
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Research Articles on IL17B

1. Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IL17B antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL17 Signaling Pathway antibodies  IL17 Signaling Pathway Diagram

Diseases associated with anti-IL17B antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >5 publications with IL17B and Necrosis
 Inflammation Antibodies  >4 publications with IL17B and Inflammation
 Disease Models, Animal Antibodies  >3 publications with IL17B and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >1 publications with IL17B and Neurobehavioral Manifestations
 Liver Neoplasms Antibodies  >1 publications with IL17B and Liver Neoplasms
 Nervous System Diseases Antibodies  >1 publications with IL17B and Nervous System Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with IL17B and Drug-Related Side Effects and Adverse Reactions

Organs/Tissues associated with anti-IL17B antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >4 publications with IL17B and Bone
 Heart Antibodies  >1 publications with IL17B and Heart
 Lung Antibodies  >1 publications with IL17B and Lung
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