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KIN Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178046

Description: Rabbit IgG polyclonal antibody for DNA/RNA-binding protein KIN17(KIN) detection. Tested with WB, IHC-P in Human;Mouse. Background: DNA/RNA-binding protein KIN17, also known as BTCD or KIN17, is a protein that in humans is encoded by the KIN gene.… More details

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Product Overview

Online Datasheet in PDF
Product Name
KIN, Polyclonal Antibody
Full Product Name
Anti-KIN Antibody
Product Gene Name
anti-KIN antibody
Product Synonym Names
DNA/RNA-binding protein KIN17; antigenic determinant of recA protein homolog; Binding to curved DNA; BTCD; DNA/RNA-binding protein KIN17; HsKin17 protein; KIN; KIN antigenic determinant of recA protein homolog mouse; KIN17; Kin17 protein; KIN17_HUMAN; KIN, antigenic determinant of recA protein homolog (mouse)
Clonality
Polyclonal
Species Reactivity
Human, Mouse
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
43,261 Da
OMIM
601720
3D Structure
ModBase 3D Structure for O60870
Immunogen
E Coli-derived human KIN recombinant protein (Position: K3-K202). Human KIN shares 98% amino acid (aa) sequence identity with mouse KIN.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-KIN antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-KIN antibody
Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml

Western Blot (WB) of anti-KIN antibody

Anti- KIN Picoband antibody, MBS178046, Western blotting
All lanes: Anti KIN (MBS178046) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: 22RV1 Whole Cell Lysate at 40ug
Lane 3: COLO320 Whole Cell Lysate at 40ug
Lane 4: MCF-7 Whole Cell Lysate at 40ug
Lane 5: U20S Whole Cell Lysate at 40ug
Lane 6: NIH3T3 Whole Cell Lysate at 40ug
Predicted bind size: 45KD
Observed bind size: 45KD
Anti-KIN Polyclonal Antibody – Cat# MBS178046

Immunohistochemistry (IHC) of anti-KIN antibody

Anti- KIN Picoband antibody, MBS178046, IHC(P)
IHC(P): Human Oesophagus Squama Cancer Tissue
Anti-KIN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS178046

Product References and Citations for anti-KIN antibody

1. Kannouche, P., Mauffrey, P., Pinon-Lataillade, G., Mattei, M. G., Sarasin, A., Daya-Grosjean, L., Angulo, J. F. Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans. Carcinogenesis 21: 1701-1710, 2000. 2. Timchenko, T., Bailone, A., Devoret, R. Btcd, a mouse protein that binds to curved DNA, can substitute in Escherichia coli for H-NS, a bacterial nucleoid protein. EMBO J. 15: 3986-3992, 1996.

Other Notes

Small volumes of anti-KIN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KIN purchase

MBS178046 is an antibody targeting KIN. Reactive in Human, Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for KIN. It may not necessarily be applicable to this product.

NCBI GI #
13124883
NCBI GeneID
22944
NCBI Accession #
NP_036443.1
UniProt Primary Accession #
O60870
UniProt Secondary Accession #
B4DX32
UniProt Related Accession #
O60870
GenBank Nucleotide #
NM_012311.3
NCBI Official Full Name
DNA/RNA-binding protein KIN17
NCBI Official Synonym Full Names
Kin17 DNA and RNA binding protein
NCBI Official Symbol
KIN
NCBI Official Synonym Symbols
BTCD; Rts2; KIN17
UniProt Protein Name
DNA/RNA-binding protein KIN17
UniProt Synonym Protein Names
Binding to curved DNA; KIN, antigenic determinant of recA protein homolog
Protein Family
DNA/RNA-binding protein
UniProt Gene Name
KIN
UniProt Entry Name
KIN17_HUMAN
NCBI Protein Information
DNA/RNA-binding protein KIN17

NCBI Summary for KIN

The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
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UniProt Comments for KIN

KIN: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro. Belongs to the KIN17 family.

Protein type: DNA replication; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 10p14

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nuclear matrix; nucleus

Molecular Function: DNA binding; double-stranded DNA binding; metal ion binding; RNA binding

Biological Process: DNA recombination; DNA repair; DNA replication; mRNA processing; response to DNA damage stimulus; viral reproduction
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Research Articles on KIN

1. overexpression of KIN rendered colorectal cancer cells enriching cancer stem cell (CSC) markers and CSC phenotype, and silencing KIN reduced CSC markers and CSC phenotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KIN antibody

 Reference Product  PubMed Publications
 PCNA antibody  >6 publications with KIN and PCNA
 ATF2 antibody  >3 publications with KIN and ATF2
 RPA1 antibody  >2 publications with KIN and RPA1
 OMP antibody  >1 publications with KIN and OMP
 METTL22 antibody  >1 publications with KIN and METTL22

Diseases associated with anti-KIN antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >356 publications with KIN and Cardiovascular Diseases
 Vascular Diseases Antibodies  >244 publications with KIN and Vascular Diseases
 Liver Diseases Antibodies  >102 publications with KIN and Liver Diseases
 Adenocarcinoma Antibodies  >102 publications with KIN and Adenocarcinoma
 Male Urogenital Diseases Antibodies  >101 publications with KIN and Male Urogenital Diseases
 Diabetes Mellitus Antibodies  >83 publications with KIN and Diabetes Mellitus
 Hemorrhage Antibodies  >68 publications with KIN and Hemorrhage
 Liver Neoplasms Antibodies  >65 publications with KIN and Liver Neoplasms
 Inflammation Antibodies  >59 publications with KIN and Inflammation
 Neuromuscular Diseases Antibodies  >57 publications with KIN and Neuromuscular Diseases

Organs/Tissues associated with anti-KIN antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >548 publications with KIN and Blood
 Muscle Antibodies  >442 publications with KIN and Muscle
 Brain Antibodies  >399 publications with KIN and Brain
 Liver Antibodies  >184 publications with KIN and Liver
 Lung Antibodies  >175 publications with KIN and Lung
 Kidney Antibodies  >106 publications with KIN and Kidney
 Pancreas Antibodies  >103 publications with KIN and Pancreas
 Nerve Antibodies  >94 publications with KIN and Nerve
 Skin Antibodies  >86 publications with KIN and Skin
 Stomach Antibodies  >63 publications with KIN and Stomach
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