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MCF2L Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8574373

This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MCF2L, Polyclonal Antibody
Full Product Name
MCF2L Polyclonal Antibody
Product Gene Name
anti-MCF2L antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
102-128kDa
OMIM
609499
3D Structure
ModBase 3D Structure for O15068
Immunogen
Recombinant protein of human MCF2L (NP_079255.4).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MCF2L antibody
Western Blot (WB)
Application Notes for anti-MCF2L antibody
WB: 1:1000-1:4000

Other Notes

Small volumes of anti-MCF2L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCF2L purchase

MBS8574373 is an antibody targeting MCF2L. Also known as MCF2L Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MCF2L. It may not necessarily be applicable to this product.

NCBI GI #
163644323
NCBI GeneID
23263
NCBI Accession #
NP_079255.3
UniProt Primary Accession #
O15068
UniProt Related Accession #
O15068
GenBank Nucleotide #
NP_079255.3
NCBI Official Full Name
guanine nucleotide exchange factor DBS isoform b
NCBI Official Synonym Full Names
MCF.2 cell line derived transforming sequence like
NCBI Official Symbol
MCF2L
NCBI Official Synonym Symbols
DBS; OST; ARHGEF14
UniProt Protein Name
Guanine nucleotide exchange factor DBS
UniProt Synonym Protein Names
DBL's big sister; MCF2-transforming sequence-like protein
Protein Family
Guanine nucleotide exchange factor
UniProt Gene Name
MCF2L
UniProt Synonym Gene Names
KIAA0362
UniProt Entry Name
MCF2L_HUMAN
NCBI Protein Information
guanine nucleotide exchange factor DBS

UniProt Comments for MCF2L

ARHGEF14: Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42. Belongs to the MCF2 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: extracellular space; lamellipodium; plasma membrane; cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity; phosphatidylinositol binding

Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; positive regulation of transcription from RNA polymerase II promoter; Rho protein signal transduction
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Research Articles on MCF2L

1. When compared to the gemcitabine-sensitive cells, the gemcitabine-resistant cells had a higher level of MCF2L expression, suggesting that MCF2L plays an important role in gemcitabine resistance

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MCF2L antibody

 Products by Pathway  Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 NRAGE Signals Death Through JNK Pathway antibodies  NRAGE Signals Death Through JNK Pathway Diagram
 Neurotrophic Factor-mediated Trk Receptor Signaling Pathway antibodies  Neurotrophic Factor-mediated Trk Receptor Signaling Pathway Diagram
 Regulation Of CDC42 Activity Pathway antibodies  Regulation Of CDC42 Activity Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-MCF2L antibody

 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >3 publications with MCF2L and Cell Transformation, Neoplastic
 Hypertrophy Antibodies  >1 publications with MCF2L and Hypertrophy
 Neurobehavioral Manifestations Antibodies  >1 publications with MCF2L and Neurobehavioral Manifestations
 Renal Insufficiency Antibodies  >1 publications with MCF2L and Renal Insufficiency
 Nervous System Diseases Antibodies  >1 publications with MCF2L and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with MCF2L and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with MCF2L and Kidney Diseases

Organs/Tissues associated with anti-MCF2L antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with MCF2L and Brain
 Thymus Antibodies  >2 publications with MCF2L and Thymus
 Prostate Antibodies  >2 publications with MCF2L and Prostate
 Parathyroid Antibodies  >1 publications with MCF2L and Parathyroid
 Ascites Antibodies  >1 publications with MCF2L and Ascites
 Muscle Antibodies  >1 publications with MCF2L and Muscle
 Liver Antibodies  >1 publications with MCF2L and Liver
 Intestine Antibodies  >1 publications with MCF2L and Intestine
 Kidney Antibodies  >1 publications with MCF2L and Kidney
 Bone Antibodies  >1 publications with MCF2L and Bone
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