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MEAF6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9432248

This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in… More details

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Product Overview

Online Datasheet in PDF
Product Name
MEAF6, Polyclonal Antibody
Full Product Name
MEAF6 Polyclonal Antibody
Product Gene Name
anti-MEAF6 antibody
Product Synonym Names
MEAF6; C1orf149; CENP-28; EAF6; NY-SAR-91; MYST/Esa1 associated factor 6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS with 50% glycerol, pH7.4
Purity/Purification
Affinity purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
OMIM
611001
3D Structure
ModBase 3D Structure for Q9HAF1
Immunogen
Recombinant fusion protein of human MEAF6 (NP_001257804.1).
Conjugation
Unconjugated

Product Categories/Family for anti-MEAF6 antibody

Total protein Ab
Applications Tested/Suitable for anti-MEAF6 antibody
Western Blot (WB)
Application Notes for anti-MEAF6 antibody
WB: 1:500-1:2000

Western Blot (WB) of anti-MEAF6 antibody

Western blot analysis of extracts of various cell lines, using MEAF6 antibody.
Rabbit Anti-MEAF6 Polyclonal Antibody – Cat# MBS9432248

Other Notes

Small volumes of anti-MEAF6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MEAF6 purchase

MBS9432248 is an antibody targeting MEAF6. Also known as MEAF6 Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MEAF6. It may not necessarily be applicable to this product.

NCBI GI #
400153656
NCBI GeneID
64769
NCBI Accession #
NP_001257804.1
UniProt Primary Accession #
Q9HAF1
UniProt Related Accession #
Q9HAF1
GenBank Nucleotide #
NM_001270875.1
NCBI Official Full Name
chromatin modification-related protein MEAF6 isoform 2
NCBI Official Synonym Full Names
MYST/Esa1 associated factor 6
NCBI Official Symbol
MEAF6
NCBI Official Synonym Symbols
EAF6; CENP-28; C1orf149; NY-SAR-91
UniProt Protein Name
Chromatin modification-related protein MEAF6
UniProt Synonym Protein Names
Esa1-associated factor 6 homolog; Protein EAF6 homolog; hEAF6; Sarcoma antigen NY-SAR-91
Protein Family
Chromatin modification-related protein
UniProt Gene Name
MEAF6
UniProt Synonym Gene Names
C1orf149; EAF6; MYST/Esa1-associated factor 6; Protein EAF6 homolog; hEAF6
UniProt Entry Name
EAF6_HUMAN
NCBI Protein Information
chromatin modification-related protein MEAF6

UniProt Comments for MEAF6

MEAF6: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Belongs to the EAF6 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Unknown function

Chromosomal Location of Human Ortholog: 1p35.3-p33

Cellular Component: nucleoplasm; centrosome; NuA4 histone acetyltransferase complex; cytoplasm; nucleolus

Molecular Function: protein binding

Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent
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Research Articles on MEAF6

1. These findings suggest that the MEAF6-1 variant does not induce neuroendocrine differentiation of prostate cancer cells, but rather facilitates t-NEPC progression by increasing the proliferation rate of cells that have acquired neuroendocrine phenotypes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MEAF6 antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram

Organs/Tissues associated with anti-MEAF6 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with MEAF6 and Brain
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