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MLL4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9515508

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal… More details

$300 / 0.05 mL +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MLL4, Polyclonal Antibody
Full Product Name
MLL4 Rabbit Polyclonal Antibody
Product Gene Name
anti-MLL4 antibody
Product Synonym Gene Name
WBP7, HRX2, KIAA0304, KMT2B, MLL2, MLL4, TRX2
Product Synonym Names
BH6842; Histone-lysine N-methyltransferase MLL4 (EC 2.1.1.43)(Lysine N-methyltransferase 2B)(KMT2B)(Myeloid/lymphoid or mixed-lineage leukemia protein 4)(Trithorax homolog 2)(WW domain-binding protein 7)(WBP-7)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1mg/ml (lot specific)
Specificity
MLL4 Polyclonal Antibody detects endogenous levels of protein.
Preparation and Storage
Store at -20 degree C/1 year
OMIM
606834
3D Structure
ModBase 3D Structure for Q9UMN6
Immunogen
Synthesized peptide derived from human protein. at AA range: 1060-1140
Modification
Unmodified/Total
Applications Tested/Suitable for anti-MLL4 antibody
Immunohistochemistry-Paraffin (IHC-P), Immunofluorescence (IF)(paraffin section)
Application Notes for anti-MLL4 antibody
IHC-p: 1:50-300

Other Notes

Small volumes of anti-MLL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MLL4 purchase

MBS9515508 is an antibody targeting MLL4. Also known as MLL4 Rabbit Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MLL4. It may not necessarily be applicable to this product.

NCBI GI #
7662046
NCBI GeneID
9757
NCBI Accession #
NP_055542.1
UniProt Primary Accession #
Q9UMN6
UniProt Secondary Accession #
O15022; O95836; Q96GP2; Q96IP3; Q9UK25; Q9Y668; Q9Y669
UniProt Related Accession #
Q9UMN6
GenBank Nucleotide #
NM_014727.2
NCBI Official Full Name
histone-lysine N-methyltransferase 2B
NCBI Official Synonym Full Names
lysine (K)-specific methyltransferase 2B
NCBI Official Symbol
KMT2B
NCBI Official Synonym Symbols
HRX2; MLL2; MLL4; TRX2; WBP7; MLL1B; WBP-7
UniProt Protein Name
Histone-lysine N-methyltransferase 2B
UniProt Synonym Protein Names
Myeloid/lymphoid or mixed-lineage leukemia protein 4; Trithorax homolog 2; WW domain-binding protein 7; WBP-7
UniProt Gene Name
KMT2B
UniProt Synonym Gene Names
HRX2; KIAA0304; MLL2; MLL4; TRX2; WBP7; Lysine N-methyltransferase 2B; WBP-7
UniProt Entry Name
KMT2B_HUMAN
NCBI Protein Information
histone-lysine N-methyltransferase 2B; trithorax homologue 2; WW domain binding protein 7; mixed lineage leukemia gene homolog 2; histone-lysine N-methyltransferase MLL4; myeloid/lymphoid or mixed-lineage leukemia protein 4; myeloid/lymphoid or mixed-line

UniProt Comments for MLL4

MLL2: may be a transcriptional regulator. Contains 3 A.T hook DNA-binding domains. Two alternatively spliced isoforms have been described.

Protein type: Methyltransferase; EC 2.1.1.43; Transcription factor; Methyltransferase, protein lysine; DNA-binding

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: nucleoplasm; histone methyltransferase complex; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); transcription factor activity

Biological Process: ovulation; establishment and/or maintenance of chromatin architecture; ovarian follicle development; transcription, DNA-dependent; chromatin-mediated maintenance of transcription; histone H3-K4 methylation; oocyte differentiation; regulation of histone H3-K4 methylation; gene silencing
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Research Articles on MLL4

1. KMT2B transgene mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MLL4 antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 PKMTs Methylate Histone Lysines Pathway antibodies  PKMTs Methylate Histone Lysines Pathway Diagram

Diseases associated with anti-MLL4 antibody

 Disease Name  Pubmed Publications
 Leukemia, Myeloid Antibodies  >3 publications with MLL4 and Leukemia, Myeloid
 Cognition Disorders Antibodies  >1 publications with MLL4 and Cognition Disorders
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