MR1 Antibody – Rabbit Polyclonal

MR1: Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand- dependent. Belongs to the MHC class I family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q25.3

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; extracellular region; integral to membrane; plasma membrane; MHC class I protein complex

Molecular Function: MHC class I receptor activity; peptide antigen binding; antigen binding

Biological Process: antigen processing and presentation; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of T cell mediated cytotoxicity; interleukin-17 production; interleukin-1 beta production; innate immune response; immune response; cytokine production during immune response; signal transduction; defense response to Gram-negative bacterium