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MYOZ1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6323539

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. This protein plays an important role in the… More details

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Product Overview

Online Datasheet in PDF
Product Name
MYOZ1, Polyclonal Antibody
Full Product Name
MYOZ1, ID (MYOZ1, MYOZ, Myozenin-1, Calsarcin-2, Filamin-, actinin-and telethonin-binding protein, Protein FATZ) (AP)
Product Gene Name
Product Synonym Names
MYOZ1; MYOZ; Myozenin-1; Calsarcin-2; Filamin-; actinin-and telethonin-binding protein; Protein FATZ
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
299
OMIM
605603
3D Structure
ModBase 3D Structure for Q9NP98
Immunogen
MYOZ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-78 amino acids from the Central region of human MYOZ1.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-MYOZ1 antibody

Applications Tested/Suitable for anti-MYOZ1 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-MYOZ1 antibody
IHC: 1:50-100
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-MYOZ1 antibody

Western blot analysis of MYOZ1 Antibody (Center) in MDA-MB231 cell line lysates (35ug/lane).MYOZ1 (arrow) was detected using the purified Pab.
Rabbit Anti-MYOZ1 Polyclonal Antibody – Cat# MBS6323539

Immunohistochemistry (IHC) of anti-MYOZ1 antibody

MYOZ1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MYOZ1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-MYOZ1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6323539

Flow Cytometry (FC/FACS) of anti-MYOZ1 antibody

MYOZ1 Antibody (Center) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-MYOZ1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6323539

Product References and Citations for anti-MYOZ1 antibody

Aurino, S., et al. Acta Myol 27, 90-97 (2008). Posch, M.G., et al. Mol. Genet. Metab. 91(2):207-208(2007). Arola, A.M., et al. Mol. Genet. Metab. 90(4):435-440(2007).

Other Notes

Small volumes of anti-MYOZ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MYOZ1 purchase

MBS6323539 is an antibody targeting MYOZ1. Also known as MYOZ1, ID (MYOZ1, MYOZ, Myozenin-1, Calsarcin-2, Filamin-, actinin-and telethonin-binding protein, Protein FATZ) (AP). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MYOZ1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Myozenin-1
NCBI Official Synonym Full Names
myozenin 1
NCBI Official Symbol
MYOZ1
NCBI Official Synonym Symbols
CS-2; FATZ; MYOZ
UniProt Protein Name
Myozenin-1
UniProt Synonym Protein Names
Calsarcin-2; Filamin-, actinin- and telethonin-binding protein; Protein FATZ
Protein Family
UniProt Gene Name
MYOZ1
UniProt Entry Name
MYOZ1_HUMAN
NCBI Protein Information
myozenin-1; MYOZ1; calsarcin-2; filamin-, actinin- and telethonin-binding protein

NCBI Summary for MYOZ1

The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]
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UniProt Comments for MYOZ1

MYOZ1: Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Belongs to the myozenin family.

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: pseudopodium; nucleus; actin cytoskeleton

Molecular Function: protein binding; FATZ binding

Biological Process: myofibril assembly
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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