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MYSM1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9447618

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes.… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MYSM1, Polyclonal Antibody
Full Product Name
MYSM1 Conjugated Antibody
Product Gene Name
anti-MYSM1 antibody
Product Synonym Names
2ADUB; 2A-DUB; RP4-592A1.1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
Specificity
The antibody detects endogenous levels of total MYSM1 protein.
Preparation and Storage
Store at 4 degree C for 6 months.
Molecular Weight
61.0kDa (547aa) 70-100KDa (SDS-PAGE under reducing conditions.)
OMIM
612176
3D Structure
ModBase 3D Structure for Q5VVJ2
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human Myb-like, SWIRM and MPN domains 1
Conjugation
Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
Excitation Emission
AF350: 346nm/442nm
Applications Tested/Suitable for anti-MYSM1 antibody
Most Applications
Application Notes for anti-MYSM1 antibody
Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-MYSM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MYSM1 purchase

MBS9447618 is an antibody targeting MYSM1. Also known as MYSM1 Conjugated Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MYSM1. It may not necessarily be applicable to this product.

NCBI GI #
71274107
NCBI GeneID
4162
NCBI Accession #
NP_006491
UniProt Primary Accession #
Q5VVJ2
UniProt Secondary Accession #
O95812; Q59E86; Q6PHR3; Q6ZTR2
UniProt Related Accession #
P43121
GenBank Nucleotide #
NM_006500.2
NCBI Official Full Name
cell surface glycoprotein MUC18
NCBI Official Synonym Full Names
melanoma cell adhesion molecule
NCBI Official Symbol
MCAM
NCBI Official Synonym Symbols
CD146; MUC18
UniProt Protein Name
Histone H2A deubiquitinase MYSM1
UniProt Synonym Protein Names
Myb-like, SWIRM and MPN domain-containing protein 1
Protein Family
Histone H2A deubiquitinase
UniProt Gene Name
MYSM1
UniProt Synonym Gene Names
KIAA1915; 2A-DUB
UniProt Entry Name
MYSM1_HUMAN
NCBI Protein Information
cell surface glycoprotein MUC18

UniProt Comments for MYSM1

MYSM1: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Belongs to the peptidase M67A family. MYSM1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.19.-; Ubiquitin-specific protease; Protease; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1p32.1

Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus

Molecular Function: DNA binding; metallopeptidase activity; histone binding; metal ion binding; transcription coactivator activity; ubiquitin-specific protease activity; protein complex binding; chromatin binding

Biological Process: chromatin remodeling; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; proteolysis
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Research Articles on MYSM1

1. We demonstrate that ER(+) breast cancers contain two CAF subtypes defined by CD146 expression. CD146(neg) CAFs suppress ER expression in ER(+) breast cancer cells, decrease tumor cell sensitivity to estrogen, and increase tumor cell resistance to tamoxifen therapy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MYSM1 antibody

 Reference Product  PubMed Publications
 FGF2 antibody  >8 publications with MYSM1 and FGF2
 PTK2 antibody  >4 publications with MYSM1 and PTK2
 TGFB1 antibody  >4 publications with MYSM1 and TGFB1
 ATF3 antibody  >2 publications with MYSM1 and ATF3
 LGALS1 antibody  >2 publications with MYSM1 and LGALS1
 ESR1 antibody  >2 publications with MYSM1 and ESR1
 CYP1B1 antibody  >1 publications with MYSM1 and CYP1B1
 EDN1 antibody  >1 publications with MYSM1 and EDN1

Diseases associated with anti-MYSM1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >41 publications with MYSM1 and Inflammation
 Lung Diseases Antibodies  >32 publications with MYSM1 and Lung Diseases
 Disease Models, Animal Antibodies  >29 publications with MYSM1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >26 publications with MYSM1 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >26 publications with MYSM1 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >25 publications with MYSM1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >24 publications with MYSM1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >23 publications with MYSM1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >20 publications with MYSM1 and Nervous System Diseases
 Prostatic Neoplasms Antibodies  >17 publications with MYSM1 and Prostatic Neoplasms

Organs/Tissues associated with anti-MYSM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >148 publications with MYSM1 and Blood
 Vascular Antibodies  >115 publications with MYSM1 and Vascular
 Skin Antibodies  >55 publications with MYSM1 and Skin
 Bone Antibodies  >55 publications with MYSM1 and Bone
 Lung Antibodies  >49 publications with MYSM1 and Lung
 Embryonic Tissue Antibodies  >41 publications with MYSM1 and Embryonic Tissue
 Bone Marrow Antibodies  >38 publications with MYSM1 and Bone Marrow
 Muscle Antibodies  >31 publications with MYSM1 and Muscle
 Brain Antibodies  >25 publications with MYSM1 and Brain
 Liver Antibodies  >23 publications with MYSM1 and Liver
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