NCKPL Antibody – Rabbit Polyclonal

HEM1: a component of the Scar/WAVE complex that plays an important role in regulating cell shape and motility. Found at elevated levels in cells of hematopoietic lineage. Localizes to propagating waves at the leading edge of a motile human neutrophils. The complex stimulates actin assembly; polymerized actin is reciprocally required to remove the complex from the membrane. Overexpression is associated with poor outcome in B-cell chronic lymphocytic leukemia patients.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: membrane; integral to plasma membrane; cytosol

Molecular Function: protein binding; protein complex binding; protein kinase activator activity

Biological Process: response to drug; neutrophil chemotaxis; erythrocyte development; positive regulation of erythrocyte differentiation; myeloid cell homeostasis; positive regulation of cell adhesion mediated by integrin; positive regulation of CD4-positive, alpha beta T cell differentiation; maintenance of cell polarity; chemotaxis; positive regulation of CD8-positive, alpha-beta T cell differentiation; positive regulation of lymphocyte differentiation; B cell receptor signaling pathway; negative regulation of interleukin-17 production; B cell homeostasis; positive regulation of actin filament polymerization; positive regulation of protein kinase activity; negative regulation of interleukin-6 production; positive regulation of B cell proliferation; positive regulation of B cell differentiation; positive regulation of T cell proliferation; T cell homeostasis; protein complex assembly; positive regulation of gamma-delta T cell differentiation; cortical actin cytoskeleton organization and biogenesis; positive regulation of phagocytosis, engulfment; positive regulation of phosphorylation; negative regulation of apoptosis