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NDUFS3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9409453

This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency. More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NDUFS3, Polyclonal Antibody
Full Product Name
NDUFS3 Antibody
Product Gene Name
anti-NDUFS3 antibody
Product Synonym Names
CI-30
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Purity/Purification
Antigen affinity purification.
Concentration
1.6 mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total NDUFS3 protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
14,679 Da
OMIM
603846
3D Structure
ModBase 3D Structure for O75489
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to a region derived from internal residues of human NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
Target Name
NDUFS3

Product Categories/Family for anti-NDUFS3 antibody

Total protein Ab
Applications Tested/Suitable for anti-NDUFS3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-NDUFS3 antibody
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200

Testing Data of anti-NDUFS3 antibody

Gel: 8%SDS-PAGE Lysates (from left to right): Mouse brain and human fetal brain tissue, hela, Raw264.7, NIH/3T3 and 293T cell Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 5 seconds
Rabbit Anti-NDUFS3 Polyclonal Antibody – Cat# MBS9409453

Immunohistochemistry (IHC) of anti-NDUFS3 antibody

Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/30.
Rabbit Anti-NDUFS3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9409453

Other Notes

Small volumes of anti-NDUFS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NDUFS3 purchase

MBS9409453 is an antibody targeting NDUFS3. Also known as NDUFS3 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NDUFS3. It may not necessarily be applicable to this product.

NCBI GI #
4758788
NCBI GeneID
4722
NCBI Accession #
NP_004542.1
UniProt Primary Accession #
O75489
UniProt Secondary Accession #
Q9UNQ8; B2R9J1; B4DFM8
UniProt Related Accession #
O75489
GenBank Nucleotide #
NM_004551.2
NCBI Official Full Name
NADH dehydrogenase
NCBI Official Synonym Full Names
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NCBI Official Symbol
NDUFS3
NCBI Official Synonym Symbols
CI-30
UniProt Protein Name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
UniProt Synonym Protein Names
Complex I-30kD; CI-30kD; NADH-ubiquinone oxidoreductase 30 kDa subunit
UniProt Gene Name
NDUFS3
UniProt Synonym Gene Names
CI-30kD
UniProt Entry Name
NDUS3_HUMAN
NCBI Protein Information
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

UniProt Comments for NDUFS3

NDUFS3: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I 30 kDa subunit family.

Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylation; Oxidoreductase; EC 1.6.99.3; EC 1.6.5.3

Chromosomal Location of Human Ortholog: 11p11.11

Cellular Component: mitochondrion; mitochondrial membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex I; nucleus

Molecular Function: protein binding; electron carrier activity; NADH dehydrogenase (ubiquinone) activity; NADH dehydrogenase activity

Biological Process: cellular metabolic process; substantia nigra development; mitochondrial electron transport, NADH to ubiquinone; negative regulation of cell growth

Disease: Leigh Syndrome; Mitochondrial Complex I Deficiency
Show more

Research Articles on NDUFS3

1. pH stability of w-t and Leigh syndrome mutant varied at extreme acidic pH. the molten globule like structure of w-t at pH1 was absent in case of the mutant protein. Both the w-t and mutant proteins showed multi-step thermal and Gdn-HCl induced unfolding

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NDUFS3 antibody

 Reference Product  PubMed Publications
 NDUFV2 antibody  >8 publications with NDUFS3 and NDUFV2
 NDUFV1 antibody  >7 publications with NDUFS3 and NDUFV1
 NDUFS2 antibody  >6 publications with NDUFS3 and NDUFS2
 NDUFS1 antibody  >5 publications with NDUFS3 and NDUFS1
 NDUFS8 antibody  >4 publications with NDUFS3 and NDUFS8
 NDUFA2 antibody  >3 publications with NDUFS3 and NDUFA2
 NDUFB6 antibody  >2 publications with NDUFS3 and NDUFB6
 NDUFS7 antibody  >2 publications with NDUFS3 and NDUFS7
 NDUFAF3 antibody  >1 publications with NDUFS3 and NDUFAF3

Pathways associated with anti-NDUFS3 antibody

 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Electron Transport Chain Pathway antibodies  Electron Transport Chain Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway antibodies  NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway Diagram
 NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway antibodies  NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram

Diseases associated with anti-NDUFS3 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >10 publications with NDUFS3 and Death
 Nervous System Diseases Antibodies  >7 publications with NDUFS3 and Nervous System Diseases
 Diabetes Mellitus Antibodies  >5 publications with NDUFS3 and Diabetes Mellitus
 Breast Neoplasms Antibodies  >5 publications with NDUFS3 and Breast Neoplasms
 Kidney Diseases Antibodies  >4 publications with NDUFS3 and Kidney Diseases
 Hypertrophy Antibodies  >2 publications with NDUFS3 and Hypertrophy
 Leigh Disease Antibodies  >2 publications with NDUFS3 and Leigh Disease
 Ovarian Diseases Antibodies  >2 publications with NDUFS3 and Ovarian Diseases
 Cardiovascular Diseases Antibodies  >2 publications with NDUFS3 and Cardiovascular Diseases
 Optic Atrophy Antibodies  >2 publications with NDUFS3 and Optic Atrophy

Organs/Tissues associated with anti-NDUFS3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with NDUFS3 and Blood
 Kidney Antibodies  >7 publications with NDUFS3 and Kidney
 Brain Antibodies  >6 publications with NDUFS3 and Brain
 Muscle Antibodies  >4 publications with NDUFS3 and Muscle
 Liver Antibodies  >3 publications with NDUFS3 and Liver
 Embryonic Tissue Antibodies  >2 publications with NDUFS3 and Embryonic Tissue
 Heart Antibodies  >2 publications with NDUFS3 and Heart
 Adipose Tissue Antibodies  >1 publications with NDUFS3 and Adipose Tissue
 Connective Tissue Antibodies  >1 publications with NDUFS3 and Connective Tissue
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