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NGFR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240393

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic… More details

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Product Overview

Online Datasheet in PDF
Product Name
NGFR / CD271 / p75, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human NGFR / CD271 / p75
Product Gene Name
anti-NGFR antibody
Product Synonym Gene Name
CD271; p75
Product Synonym Names
Anti-NGFR / CD271 / p75 Antibody IHC-plus; NGFR; CD271; CD271 antigen; gp80-LNGFR; Nerve growth factor receptor; p75 ICD; p75(NTR); p75NTR; TNFR superfamily; member 16; NGF receptor; TNFRSF16; Human NGFR; CD271; p75
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
purified recombinant human NGFR
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
35,767 Da
OMIM
162010
3D Structure
ModBase 3D Structure for P08138
Target Species
Human
Immunogen Description
Recombinant human NGFR.
Immunogen Type
Recombinant protein
Immunogen
NGFR / CD271 / p75 antibody was raised against recombinant human NGFR.

Product Categories/Family for anti-NGFR antibody

Family: TNF Receptor
Applications Tested/Suitable for anti-NGFR antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB)
Application Notes for anti-NGFR antibody
ICC, IHC-P (5 ug/ml), WB (1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-NGFR antibody

Anti-NGFR antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-NGFR Polyclonal Antibody – Cat# MBS240393

Immunohistochemistry (IHC) of anti-NGFR antibody

Anti-NGFR antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-NGFR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS240393

Immunocytochemistry (ICC) of anti-NGFR antibody

Immunocytochemistry of NGFR in A20 cells with NGFR antibody at 10 ug/ml.
Rabbit Anti-NGFR Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS240393

Western Blot (WB) of anti-NGFR antibody

Western blot of (A) 25 ng, (B) 50 ng, and (C) 100 ng of purified recombinant NGFR with NGFR antibody at 1 ug/ml.
Rabbit Anti-NGFR Polyclonal Antibody, Western Blot (WB) – Cat# MBS240393

Other Notes

Small volumes of anti-NGFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NGFR purchase

MBS240393 is an antibody targeting NGFR. Also known as Rabbit Polyclonal to Human NGFR / CD271 / p75. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NGFR. It may not necessarily be applicable to this product.

NCBI GI #
4505393
NCBI GeneID
4804
NCBI Accession #
NP_002498.1
UniProt Primary Accession #
P08138
UniProt Secondary Accession #
B2R961; B4E096
UniProt Related Accession #
P08138
GenBank Nucleotide #
NM_002507.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 16
NCBI Official Synonym Full Names
nerve growth factor receptor
NCBI Official Symbol
NGFR
NCBI Official Synonym Symbols
CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 16
UniProt Synonym Protein Names
Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD_antigen: CD271
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
NGFR
UniProt Synonym Gene Names
TNFRSF16; NGF receptor
UniProt Entry Name
TNR16_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 16; p75 ICD; NGF receptor; TNFR superfamily, member 16; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor

UniProt Comments for NGFR

NGFR: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q21-q22

Cellular Component: nucleoplasm; cell surface; integral to plasma membrane; plasma membrane; extracellular region; cytosol; endosome

Molecular Function: protein binding; signal transducer activity; transmembrane receptor activity; death receptor activity; ubiquitin protein ligase binding; nerve growth factor binding; receptor activity; Rab GTPase binding

Biological Process: detection of temperature stimulus; axon guidance; hair follicle morphogenesis; membrane protein intracellular domain proteolysis; central nervous system development; nerve growth factor receptor signaling pathway; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of odontogenesis of dentine-containing teeth; glucose homeostasis; regulation of axonogenesis; regulation of caspase activity; negative regulation of hair follicle development; negative regulation of cell cycle; intracellular protein transport; positive regulation of fibroblast proliferation; negative regulation of axonogenesis; nerve development; positive regulation of axonogenesis; circadian regulation of gene expression; negative regulation of apoptosis
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Research Articles on NGFR

1. elucidating the potential implications of p75(NTR) activity as well as the underlying molecular mechanisms of p75(NTR) will shed new light on the biology of both normal and cancer stem cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NGFR antibody

 Reference Product  PubMed Publications
 NGF antibody  >240 publications with NGFR and NGF
 NTRK1 antibody  >109 publications with NGFR and NTRK1
 BDNF antibody  >47 publications with NGFR and BDNF
 NTF4 antibody  >3 publications with NGFR and NTF4
 TRAF6 antibody  >1 publications with NGFR and TRAF6
 RIPK2 antibody  >1 publications with NGFR and RIPK2
 NGFRAP1 antibody  >1 publications with NGFR and NGFRAP1
 SORT1 antibody  >1 publications with NGFR and SORT1
 MAGED1 antibody  >1 publications with NGFR and MAGED1

Pathways associated with anti-NGFR antibody

 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 Axonal Growth Stimulation Pathway antibodies  Axonal Growth Stimulation Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Ceramide Signalling Pathway antibodies  Ceramide Signalling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 NADE Modulates Death Signalling Pathway antibodies  NADE Modulates Death Signalling Pathway Diagram
 NF-kB Is Activated And Signals Survival Pathway antibodies  NF-kB Is Activated And Signals Survival Pathway Diagram
 NFG And ProNGF Binds To P75NTR Pathway antibodies  NFG And ProNGF Binds To P75NTR Pathway Diagram

Diseases associated with anti-NGFR antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >124 publications with NGFR and Nervous System Diseases
 Necrosis Antibodies  >42 publications with NGFR and Necrosis
 Neurodegenerative Diseases Antibodies  >36 publications with NGFR and Neurodegenerative Diseases
 Nerve Degeneration Antibodies  >33 publications with NGFR and Nerve Degeneration
 Inflammation Antibodies  >27 publications with NGFR and Inflammation
 Disease Models, Animal Antibodies  >27 publications with NGFR and Disease Models, Animal
 Mental Disorders Antibodies  >25 publications with NGFR and Mental Disorders
 Pain Antibodies  >16 publications with NGFR and Pain
 Kidney Diseases Antibodies  >15 publications with NGFR and Kidney Diseases
 Prostatic Neoplasms Antibodies  >15 publications with NGFR and Prostatic Neoplasms

Organs/Tissues associated with anti-NGFR antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >624 publications with NGFR and Nerve
 Brain Antibodies  >200 publications with NGFR and Brain
 Bone Antibodies  >67 publications with NGFR and Bone
 Skin Antibodies  >50 publications with NGFR and Skin
 Embryonic Tissue Antibodies  >45 publications with NGFR and Embryonic Tissue
 Mouth Antibodies  >35 publications with NGFR and Mouth
 Kidney Antibodies  >27 publications with NGFR and Kidney
 Connective Tissue Antibodies  >23 publications with NGFR and Connective Tissue
 Prostate Antibodies  >16 publications with NGFR and Prostate
 Ovary Antibodies  >9 publications with NGFR and Ovary
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