Rabbit Anti-NME2 Polyclonal Antibody – Cat# MBS6490768

NME2 Antibody – Rabbit Polyclonal

Name: NME2 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6490768
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6490768

MBS6490768 is an antibody targeting NME2. Also known as NME2, NT (Nucleoside Diphosphate Kinase B, NDK B, NDP Kinase B, nm23-H2, C-myc Purine-binding Transcription Factor PUF, NM23B) (MaxLight 650). Reactive in Human, Mouse. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NME2, Polyclonal Antibody

Full Product Name

NME2, NT (Nucleoside Diphosphate Kinase B, NDK B, NDP Kinase B, nm23-H2, C-myc Purine-binding Transcription Factor PUF, NM23B) (MaxLight 650)

Product Gene Name

anti-NME2 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

Purity/Purification

Purified by Protein G Affinity Chromatography.

Specificity

Recognizes human NME2. Species Crossreactivity: mouse.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

17,298 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (49230897..49249105). Location: 17q21.3

OMIM

156491

3D Structure

ModBase 3D Structure for P22392

Immunogen

Synthetic peptide selected from the N-terminal region of human NME2 (KLH).

Conjugate

MaxLight650

Note

Preservative Free

Product Categories/Family for anti-NME2 antibody

Antibodies; Transcription Factors

Applications Tested/Suitable for anti-NME2 antibody

Immunohistochemistry (IHC), FLISA, Western Blot (WB)

Application Notes for anti-NME2 antibody

IHC: 1:50-1:100
FLISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Product References and Citations for anti-NME2 antibody

1. Munier, A., et al., Exp. Cell Res. 289(2):295-306 (2003). 2. Kim, S.H., et al., Biochem. Biophys. Res. Commun. 296(4):970-975 (2002). 3. Okabe-Kado, J., et al., Leuk. Res. 26(6):569-576 (2002). 4. Godfried, M.B., et al., Oncogene 21(13):2097-2101 (2002). 5. Postel, E.H., et al., Biochemistry 41(20):6330-6337 (2002).

Other Notes

Small volumes of anti-NME2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NME2. It may not necessarily be applicable to this product.

NCBI GI #

66392203

NCBI GeneID

654364

NCBI Accession #

NP_001018146.1

UniProt Primary Accession #

P22392

UniProt Secondary Accession #

Q1WM23; Q6LCT6; A8MWA3

GenBank Nucleotide #

NM_001018136.2

NCBI Official Full Name

NME1-NME2 protein

NCBI Official Synonym Full Names

NME1-NME2 readthrough

NCBI Official Symbol

NME1-NME2

NCBI Official Synonym Symbols

NMELV; NM23-LV

UniProt Protein Name

Nucleoside diphosphate kinase B

UniProt Synonym Protein Names

C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB (EC:2.7.13.3); nm23-H2

UniProt Gene Name

NME2

UniProt Synonym Gene Names

NM23B; NDK B; NDP kinase B

UniProt Entry Name

NDKB_HUMAN

NCBI Protein Information

NME1-NME2 protein; NME1-NME2 readthrough transcript

NCBI Summary for NME2

This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]

UniProt Comments for NME2

NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, other; Nucleotide Metabolism - pyrimidine; EC 2.7.13.3; Nucleotide Metabolism - purine; Nuclear receptor co-regulator; EC 2.7.4.6; Kinase, nucleoside diphosphate; Other group; NDK family

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: ruffle; centrosome; focal adhesion; membrane; mitochondrion; perinuclear region of cytoplasm; lamellipodium; cytoplasm; intermediate filament; cytosol; nucleus

Molecular Function: gamma-tubulin binding; protein binding; protein histidine kinase activity; metal ion binding; nucleoside diphosphate kinase activity; intermediate filament binding; protein kinase binding; transcription factor activity; ATP binding; single-stranded DNA binding

Biological Process: integrin-mediated signaling pathway; GTP biosynthetic process; peptidyl-histidine phosphorylation; response to cAMP; transcription, DNA-dependent; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; negative regulation of myeloid leukocyte differentiation; UTP biosynthetic process; hippocampus development; nucleoside diphosphate phosphorylation; response to testosterone stimulus; CTP biosynthetic process; regulation of transcription, DNA-dependent; pyrimidine nucleotide metabolic process; nucleoside triphosphate biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; cell adhesion; positive regulation of epithelial cell proliferation; regulation of epidermis development; response to amine stimulus; positive regulation of keratinocyte differentiation; purine nucleotide metabolic process; negative regulation of apoptosis

Research Articles on NME2

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NME2 antibody

Products by Pathway	Pathway Diagram
Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies	Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies	Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
CMP Phosphorylation Pathway antibodies	CMP Phosphorylation Pathway Diagram
Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies	Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies	Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Nucleotide Metabolism Pathway antibodies	Nucleotide Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram

Diseases associated with anti-NME2 antibody

Disease Name	Pubmed Publications
Lung Neoplasms Antibodies	>1 publications with NME2 and Lung Neoplasms
Neoplasm Metastasis Antibodies	>1 publications with NME2 and Neoplasm Metastasis
Anemia Antibodies	>1 publications with NME2 and Anemia
Carcinoma, Hepatocellular Antibodies	>1 publications with NME2 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-NME2 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>1 publications with NME2 and Lung