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OS9 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8567196

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
OS9, Polyclonal Antibody
Full Product Name
OS9 Polyclonal Antibody
Product Gene Name
anti-OS9 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
60kDa; 63kDa; 65kDa; 67kDa; 69kDa; 73kDa; 75kDa
OMIM
609677
3D Structure
ModBase 3D Structure for Q13438
Immunogen
Recombinant protein of human OS9 (NP_001017956.1).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-OS9 antibody
Western Blot (WB)
Application Notes for anti-OS9 antibody
WB: 1:500-1:2000

Other Notes

Small volumes of anti-OS9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OS9 purchase

MBS8567196 is an antibody targeting OS9. Also known as OS9 Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OS9. It may not necessarily be applicable to this product.

NCBI GI #
3024310
NCBI GeneID
10956
UniProt Primary Accession #
Q13438
UniProt Related Accession #
Q13438
NCBI Official Full Name
Protein OS-9
NCBI Official Synonym Full Names
OS9 endoplasmic reticulum lectin
NCBI Official Symbol
OS9
NCBI Official Synonym Symbols
OS-9; ERLEC2
UniProt Protein Name
Protein OS-9
UniProt Synonym Protein Names
Amplified in osteosarcoma 9
Protein Family
Protein
UniProt Gene Name
OS9
UniProt Entry Name
OS9_HUMAN
NCBI Protein Information
protein OS-9

UniProt Comments for OS9

OS9: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. Belongs to the OS-9 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: endoplasmic reticulum lumen

Molecular Function: protein binding; protease binding; glycoprotein binding; carbohydrate binding

Biological Process: ER-associated protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination; protein retention in ER; protein targeting
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Research Articles on OS9

1. The relative expression of OS9 and XTP3B and the distribution of glycan and non-glycan degrons within the same protein contribute to the fidelity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OS9 antibody

 Reference Product  PubMed Publications
 SEL1L antibody  >14 publications with OS9 and SEL1L
 SYVN1 antibody  >7 publications with OS9 and SYVN1
 HIF1A antibody  >6 publications with OS9 and HIF1A
 EGLN1 antibody  >1 publications with OS9 and EGLN1

Pathways associated with anti-OS9 antibody

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Calnexin/calreticulin Cycle Pathway antibodies  Calnexin/calreticulin Cycle Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 ER Quality Control Compartment (ERQC) Pathway antibodies  ER Quality Control Compartment (ERQC) Pathway Diagram
 HRD1/SEL1 ERAD Complex Pathway antibodies  HRD1/SEL1 ERAD Complex Pathway Diagram
 HRD1/SEL1 ERAD Complex Pathway antibodies  HRD1/SEL1 ERAD Complex Pathway Diagram
 Hedgehog Ligand Biogenesis Pathway antibodies  Hedgehog Ligand Biogenesis Pathway Diagram
 Hh Mutants Abrogate Ligand Secretion Pathway antibodies  Hh Mutants Abrogate Ligand Secretion Pathway Diagram
 Hh Mutants That Don't Undergo Autocatalytic Processing Are Degraded By ERAD Pathway antibodies  Hh Mutants That Don't Undergo Autocatalytic Processing Are Degraded By ERAD Pathway Diagram

Diseases associated with anti-OS9 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with OS9 and Disease Models, Animal
 Nervous System Diseases Antibodies  >2 publications with OS9 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >2 publications with OS9 and Neoplasms, Experimental
 Inflammation Antibodies  >2 publications with OS9 and Inflammation
 Neoplasm Invasiveness Antibodies  >1 publications with OS9 and Neoplasm Invasiveness
 Liver Neoplasms Antibodies  >1 publications with OS9 and Liver Neoplasms
 Hypertension Antibodies  >1 publications with OS9 and Hypertension
 Pancreatic Neoplasms Antibodies  >1 publications with OS9 and Pancreatic Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with OS9 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-OS9 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >4 publications with OS9 and Nerve
 Intestine Antibodies  >3 publications with OS9 and Intestine
 Bone Antibodies  >2 publications with OS9 and Bone
 Blood Antibodies  >2 publications with OS9 and Blood
 Liver Antibodies  >2 publications with OS9 and Liver
 Kidney Antibodies  >2 publications with OS9 and Kidney
 Lung Antibodies  >2 publications with OS9 and Lung
 Brain Antibodies  >2 publications with OS9 and Brain
 Lymph Antibodies  >1 publications with OS9 and Lymph
 Vascular Antibodies  >1 publications with OS9 and Vascular
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