P2RX2 Antibody – Rabbit Polyclonal

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]

P2X2: Binding of this ligand-gated ion channel to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Belongs to the P2X receptor family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Channel, cation

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: presynaptic membrane; cell surface; cell soma; integral to plasma membrane; postsynaptic density; apical plasma membrane; dendritic spine; terminal button; integral to nuclear inner membrane; receptor complex

Molecular Function: identical protein binding; copper ion binding; zinc ion binding; mercury ion binding; drug binding; ligand-gated ion channel activity; cadmium ion binding; ATP binding; nickel ion binding; purinergic nucleotide receptor activity; phosphoinositide binding; cobalt ion binding; ATP-gated cation channel activity

Biological Process: urinary bladder smooth muscle contraction; peristalsis; sensory perception of taste; protein heterooligomerization; generation of action potential; skeletal muscle fiber development; positive regulation of calcium-mediated signaling; detection of hypoxic conditions in blood by carotid body chemoreceptors; response to carbohydrate stimulus; response to ATP; behavioral response to pain; sensory perception of sound; response to hypoxia; neuromuscular synaptic transmission; neuromuscular junction development; protein homooligomerization

Disease: Deafness, Autosomal Dominant 41