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PDE11A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6444725

MBS6444725 is an antibody targeting PDE11A. Also known as PDE11A (Dual 3',5'-cyclic-AMP and-GMP Phosphodiesterase 11A, cAMP and cGMP Phosphodiesterase 11A) (HRP). Reactive in Human, Mouse. Host: Rabbit. More details

$1305 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PDE11A, Polyclonal Antibody
Full Product Name
PDE11A (Dual 3',5'-cyclic-AMP and-GMP Phosphodiesterase 11A, cAMP and cGMP Phosphodiesterase 11A) (HRP)
Product Gene Name
anti-PDE11A antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by affinity chromatography.
Specificity
Recognizes human GAF domain of PDE11A. Species Crossreactivity: mouse.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
Molecular Weight
105kDa
OMIM
604961. gene. :: 610475. phenotype.
3D Structure
ModBase 3D Structure for Q9HCR9
Immunogen
KLH-conjugated linear peptide corresponding to the GAF domain of human PDE11A. Species sequence homology: rat and bovine (100%)
Conjugate
HRP
Control
Human hippocampus tissue lysate
Note
Preservative Free

Product Categories/Family for anti-PDE11A antibody

Antibodies; Enzymes; Phosphodiesterase
Applications Tested/Suitable for anti-PDE11A antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-PDE11A antibody
IHC: 1:1000
Applications are based on unconjugated antibody.

Immunohistochemistry (IHC) of anti-PDE11A antibody

Immunohistochemistry Analysis: Representative lot data. Paraffin-embedded normal mouse midbrain tissue were prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:1,000 dilution Anti-PDE11A. Reactivity was detected using the IHC-Select Detection Kit Positive staining was observed in normal mouse midbrain tissue.
Rabbit Anti-PDE11A Polyclonal Antibody – Cat# MBS6444725

Western Blot (WB) of anti-PDE11A antibody

Western Blotting Analysis: Representative lot data. Human hippocampus tissue lysate was probed with Anti-PDE11A (1ug/ml). Proteins were visualized using a Donkey Anti-Rabbit IgG secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates PDE11A (~104kD).
Rabbit Anti-PDE11A Polyclonal Antibody, Western Blot (WB) – Cat# MBS6444725

Other Notes

Small volumes of anti-PDE11A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE11A. It may not necessarily be applicable to this product.

NCBI GI #
116536085
NCBI GeneID
50940
NCBI Accession #
NP_058649
UniProt Primary Accession #
Q9HCR9
UniProt Related Accession #
Q9HCR9
GenBank Nucleotide #
NM_016953
NCBI Official Full Name
dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4
NCBI Official Synonym Full Names
phosphodiesterase 11A
NCBI Official Symbol
PDE11A
NCBI Official Synonym Symbols
PPNAD2
UniProt Protein Name
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
UniProt Synonym Protein Names
cAMP and cGMP phosphodiesterase 11A
Protein Family
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase
UniProt Gene Name
PDE11A
UniProt Entry Name
PDE11_HUMAN
NCBI Protein Information
dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

NCBI Summary for PDE11A

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Show more

Research Articles on PDE11A

1. One percent of the Swedish population carries a PDE11A loss-of-function mutation which is associated with elevated BP, abdominal obesity, and risk of ischemic stroke.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PDE11A antibody

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 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
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 Nitric Oxide Stimulates Guanylate Cyclase Pathway antibodies  Nitric Oxide Stimulates Guanylate Cyclase Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with anti-PDE11A antibody

 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >21 publications with PDE11A and Hyperplasia
 Congenital Abnormalities Antibodies  >5 publications with PDE11A and Congenital Abnormalities
 Infertility, Male Antibodies  >3 publications with PDE11A and Infertility, Male
 Hypertension Antibodies  >3 publications with PDE11A and Hypertension
 Heart Diseases Antibodies  >3 publications with PDE11A and Heart Diseases
 Abnormalities, Multiple Antibodies  >3 publications with PDE11A and Abnormalities, Multiple
 Disease Models, Animal Antibodies  >2 publications with PDE11A and Disease Models, Animal
 Adenocarcinoma Antibodies  >2 publications with PDE11A and Adenocarcinoma
 Migraine Disorders Antibodies  >1 publications with PDE11A and Migraine Disorders
 Precancerous Conditions Antibodies  >1 publications with PDE11A and Precancerous Conditions

Organs/Tissues associated with anti-PDE11A antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >12 publications with PDE11A and Prostate
 Testis Antibodies  >10 publications with PDE11A and Testis
 Muscle Antibodies  >9 publications with PDE11A and Muscle
 Brain Antibodies  >8 publications with PDE11A and Brain
 Nerve Antibodies  >4 publications with PDE11A and Nerve
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