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PLXNC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6335127

MBS6335127 is an antibody targeting PLXNC1. Also known as PLXNC1, CT (PLXNC1, VESPR, Plexin-C1, Virus-encoded semaphorin protein receptor, CD232) (Biotin). Reactive in Human, Mouse. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PLXNC1, Polyclonal Antibody
Full Product Name
PLXNC1, CT (PLXNC1, VESPR, Plexin-C1, Virus-encoded semaphorin protein receptor, CD232) (Biotin)
Product Gene Name
anti-PLXNC1 antibody
Product Synonym Names
PLXNC1; VESPR; Plexin-C1; Virus-encoded semaphorin protein receptor; CD232
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human PLXNC1. Species Crossreactivity: mouse
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
175,742 Da
3D Structure
ModBase 3D Structure for O60486
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1025-1054 in the C-terminal region of human PLXNC1.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-PLXNC1 antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-PLXNC1 antibody
Immunohistochemistry (IHC) Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-PLXNC1 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-PLXNC1 antibody

Western Blot analysis in mouse liver tissue lysates (35ug/lane) usingMBS6006313. This demonstrates that MBS6006313 detected PLXNC1 (arrow).
Rabbit Anti-PLXNC1 Polyclonal Antibody – Cat# MBS6335127

Immunohistochemistry (IHC) of anti-PLXNC1 antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue using MBS6006313 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6006313 for immunohistochemistry.
Rabbit Anti-PLXNC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6335127

Product References and Citations for anti-PLXNC1 antibody

1. Liu, H., et al. Cell 142(5):749-761(2010). 2. Lazova, R., et al. Am J Dermatopathol 31(2):177-181(2009). 3. Scott, G.A., et al. J. Invest. Dermatol. 129(4):954-963(2009). 4. Scott, G.A., et al. J. Invest. Dermatol. 128(1):151-161(2008). 5. Li, Y., et al. PLoS ONE 3 (7), E2707 (2008).

Other Notes

Small volumes of anti-PLXNC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PLXNC1. It may not necessarily be applicable to this product.

NCBI GI #
5032223
NCBI GeneID
10154
NCBI Accession #
NP_005752.1
UniProt Primary Accession #
O60486
UniProt Secondary Accession #
Q59H25
UniProt Related Accession #
O60486
GenBank Nucleotide #
NM_005761.2
NCBI Official Full Name
plexin-C1
NCBI Official Synonym Full Names
plexin C1
NCBI Official Symbol
PLXNC1
NCBI Official Synonym Symbols
CD232; VESPR; PLXN-C1
UniProt Protein Name
Plexin-C1
UniProt Synonym Protein Names
Virus-encoded semaphorin protein receptor; CD_antigen: CD232
Protein Family
Plexin
UniProt Gene Name
PLXNC1
UniProt Synonym Gene Names
VESPR
NCBI Protein Information
plexin-C1

NCBI Summary for PLXNC1

This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
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UniProt Comments for PLXNC1

Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 ().

Research Articles on PLXNC1

1. Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PLXNC1 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Other Semaphorin Interactions Pathway antibodies  Other Semaphorin Interactions Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram

Diseases associated with anti-PLXNC1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with PLXNC1 and Neoplasms
 Carcinoma Antibodies  >1 publications with PLXNC1 and Carcinoma
 Adenocarcinoma Antibodies  >1 publications with PLXNC1 and Adenocarcinoma
 Nervous System Diseases Antibodies  >1 publications with PLXNC1 and Nervous System Diseases
 Pancreatic Neoplasms Antibodies  >1 publications with PLXNC1 and Pancreatic Neoplasms

Organs/Tissues associated with anti-PLXNC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with PLXNC1 and Eye
 Lung Antibodies  >1 publications with PLXNC1 and Lung
 Mouth Antibodies  >1 publications with PLXNC1 and Mouth
 Testis Antibodies  >1 publications with PLXNC1 and Testis
 Embryonic Tissue Antibodies  >1 publications with PLXNC1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with PLXNC1 and Kidney
 Brain Antibodies  >1 publications with PLXNC1 and Brain
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