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PPM1L Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6336440

PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. PP2Cs regulate stress-activated… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PPM1L, Polyclonal Antibody
Full Product Name
PPM1L, CT (PPM1L, PP2CE, Protein phosphatase 1L, Protein phosphatase 1-like, Protein phosphatase 2C isoform epsilon) (MaxLight 490)
Product Gene Name
anti-PPM1L antibody
Product Synonym Names
PPM1L; PP2CE; Protein phosphatase 1L; Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
41,053 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (160473996..160788817). Location: 3q26.1
OMIM
611931
3D Structure
ModBase 3D Structure for Q5SGD2
Immunogen
PPM1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the C-terminal region of human PPM1L.
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-PPM1L antibody

Antibodies; Enzymes; Phosphatase
Applications Tested/Suitable for anti-PPM1L antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-PPM1L antibody
IHC: 1:50-100
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-PPM1L antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Thean, L.F., et al. Genes Chromosomes Cancer 49(2):99-106(2010). Trynka, G., et al. Gut 58(8):1078-1083(2009). Saito, S., et al. J. Biol. Chem. 283(10):6584-6593(2008). Saito, J., et al. Biochem. J. 405(3):591-596(2007).

Other Notes

Small volumes of anti-PPM1L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPM1L purchase

MBS6336440 is an antibody targeting PPM1L. Also known as PPM1L, CT (PPM1L, PP2CE, Protein phosphatase 1L, Protein phosphatase 1-like, Protein phosphatase 2C isoform epsilon) (MaxLight 490). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPM1L. It may not necessarily be applicable to this product.

NCBI GI #
63003905
NCBI GeneID
151742
NCBI Accession #
NP_640338.2
UniProt Primary Accession #
Q5SGD2
UniProt Secondary Accession #
Q2M3J2; Q96NM7
UniProt Related Accession #
Q5SGD2
GenBank Nucleotide #
NM_139245.2
NCBI Official Full Name
protein phosphatase 1L
NCBI Official Synonym Full Names
protein phosphatase, Mg2+/Mn2+ dependent, 1L
NCBI Official Symbol
PPM1L
NCBI Official Synonym Symbols
PP2CE; PPM1-LIKE; PP2C-epsilon
UniProt Protein Name
Protein phosphatase 1L
UniProt Synonym Protein Names
Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon
Protein Family
Protein phosphatase
UniProt Gene Name
PPM1L
UniProt Synonym Gene Names
PP2CE; PP2C-epsilon
UniProt Entry Name
PPM1L_HUMAN
NCBI Protein Information
protein phosphatase 1L; PP2C epsilon; Protein phosphatase 2C epsilon isoform; protein phosphatase 2C isoform epsilon

UniProt Comments for PPM1L

PPM1L: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: metal ion binding; protein serine/threonine phosphatase activity

Biological Process: sphingolipid metabolic process; sphingolipid biosynthetic process; transmembrane receptor protein serine/threonine kinase signaling pathway; MAPKKK cascade; protein amino acid dephosphorylation
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Research Articles on PPM1L

1. identified ACBD3 as an interacting partner of PPM1L, and showed that this association, which recruits PPM1L to ER-Golgi membrane contact sites, is mediated by a GOLD (Golgi dynamics) domain in ACBD3

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PPM1L antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid De Novo Biosynthesis Pathway antibodies  Sphingolipid De Novo Biosynthesis Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram

Diseases associated with anti-PPM1L antibody

 Disease Name  Pubmed Publications
 Adenoma Antibodies  >1 publications with PPM1L and Adenoma
 Neoplasms Antibodies  >1 publications with PPM1L and Neoplasms
 Obesity Antibodies  >1 publications with PPM1L and Obesity

Organs/Tissues associated with anti-PPM1L antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with PPM1L and Liver
 Connective Tissue Antibodies  >1 publications with PPM1L and Connective Tissue
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