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PREX2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544365

BIOTIN-Conjugated PtdIns(3, 4, 5)-dependent Rac exchanger 2a AntibodyFunctions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Mediates the activation of RAC1 in a PI3K-dependent manner. May be… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PREX2, Polyclonal Antibody
Full Product Name
PREX2 Antibody BIOTIN-Conjugated
Product Gene Name
anti-PREX2 antibody
Product Synonym Names
4; 5)-dependent Rac exchanger 2; 5-trisphosphate-dependent Rac exchanger 2 protein; DEP domain-containing protein 2; DEP.2; Phosphatidylinositol 3; PtdIns(3, 4, 5)-dependent Rac exchanger 2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
BIOTIN-Conjugated
Concentration
0.65 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: PREX2 (MBS544365)
Positive Control: PREX2 (MBS543163)
Antibody/Peptide Pairs
PREX2 peptide (MBS544323) is used for blocking the activity of PREX2 antibody (MBS544365)
Molecular Weight
112,404 Da
OMIM
612139
3D Structure
ModBase 3D Structure for Q70Z35
Immunogen
Synthetic peptide taken within amino acid region 720-900 on PREX2 protein.
Expression
Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart.
Molecular Function
Rac GTPase activator activity, Rac guanyl-nucleotide exchange factor activity
Applications Tested/Suitable for anti-PREX2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-PREX2 antibody
Dot Blot: 1:20,000-1:50,000
ELISA: 1:20,000-1:50,000
Western Blot: 1:500-1:750

Other Notes

Small volumes of anti-PREX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PREX2 purchase

MBS544365 is an antibody targeting PREX2. Also known as PREX2 Antibody BIOTIN-Conjugated. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PREX2. It may not necessarily be applicable to this product.

NCBI GI #
51315380
NCBI Accession #
DAA05334.1
UniProt Primary Accession #
Q70Z35
UniProt Secondary Accession #
Q32KL0; Q32KL1; Q6R7Q3; Q6R7Q4; Q9H805; Q9H961; B4DFX0
NCBI Official Full Name
TPA_exp: PtdIns(3,4,5)-dependent Rac exchanger 2a
UniProt Protein Name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
UniProt Synonym Protein Names
DEP domain-containing protein 2
Protein Family
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
UniProt Gene Name
PREX2
UniProt Synonym Gene Names
DEPDC2; P-Rex2; PtdIns(3,4,5)-dependent Rac exchanger 2
UniProt Entry Name
PREX2_HUMAN

UniProt Comments for PREX2

PREX2: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Phosphatase, regulatory subunit; GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 8q13.2

Cellular Component: intracellular; plasma membrane

Molecular Function: GTPase activator activity; Rac guanyl-nucleotide exchange factor activity

Biological Process: adult locomotory behavior; dendrite morphogenesis; G-protein coupled receptor protein signaling pathway; phosphoinositide 3-kinase cascade; positive regulation of GTPase activity; regulation of Rho protein signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PREX2 antibody

 Reference Product  PubMed Publications
 PTEN antibody  >15 publications with PREX2 and PTEN
 RAC1 antibody  >15 publications with PREX2 and RAC1
 MTOR antibody  >1 publications with PREX2 and MTOR

Diseases associated with anti-PREX2 antibody

 Disease Name  Pubmed Publications
 Liver Neoplasms Antibodies  >2 publications with PREX2 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with PREX2 and Liver Diseases
 Neoplasms, Experimental Antibodies  >1 publications with PREX2 and Neoplasms, Experimental
 Hepatitis Antibodies  >1 publications with PREX2 and Hepatitis
 Fibrosis Antibodies  >1 publications with PREX2 and Fibrosis
 Disease Models, Animal Antibodies  >1 publications with PREX2 and Disease Models, Animal

Organs/Tissues associated with anti-PREX2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with PREX2 and Liver
 Blood Antibodies  >3 publications with PREX2 and Blood
 Eye Antibodies  >2 publications with PREX2 and Eye
 Vascular Antibodies  >2 publications with PREX2 and Vascular
 Lung Antibodies  >2 publications with PREX2 and Lung
 Embryonic Tissue Antibodies  >2 publications with PREX2 and Embryonic Tissue
 Brain Antibodies  >1 publications with PREX2 and Brain
 Kidney Antibodies  >1 publications with PREX2 and Kidney
 Testis Antibodies  >1 publications with PREX2 and Testis
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