Prostaglandin E Synthase 2 (PTGES2) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficient of this gene suggests that this enzyme does not contribute to prostaglandin E2 biosynthesis in vivo. This protein is synthesized as a Golgi membrane-bound protein, but its N-terminal hydrophobic region is cleaved off during protein maturation to produce the predominant soluble truncated form that still retains the enzyme activity. This soluble protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE), possibly via an interaction with CAAAT/enhancer-binding protein-beta. [provided by RefSeq, Oct 2009]

PTGES2: Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear. Belongs to the GST superfamily.

Protein type: EC 5.3.99.3; Isomerase; Lipid Metabolism - arachidonic acid; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2|2 B

Cellular Component: cytoplasm; cytosol; Golgi apparatus; integral component of membrane; membrane; mitochondrion; nucleus

Molecular Function: DNA binding; electron transfer activity; isomerase activity; prostaglandin-E synthase activity; protein disulfide oxidoreductase activity

Biological Process: cell redox homeostasis; fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolic process; positive regulation of transcription, DNA-templated; prostaglandin biosynthetic process; prostaglandin metabolic process; secretion