SLC25A17 Antibody – Rabbit Polyclonal

Function: Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD+), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD+ from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro. Ref.10 Ref.12

Subunit structure: Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol. Ref.7 Ref.9 Ref.11

Subcellular location: Cytoplasm. Peroxisome membrane; Multi-pass membrane protein Ref.8 Ref.9 Ref.11.

Tissue specificity: Ubiquitous. Expressed in liver. Ref.12

Domain: The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity.

Sequence similarities: Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Contains 3 Solcar repeats.

Caution: Was first identified as a peroxisomal ATP transporter (Ref.10). However, later experiments showed that it acts as a peroxisomal transporter for multiple cofactors (Ref.12).