SMAD7 Antibody – Rabbit Polyclonal

SMAD7: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Genetic variations in SMAD7 influence susceptibility to colorectal cancer type 3 (CRCS3). Colorectal cancer consists of tumors or cancer of either the colon or rectum or both. Cancers of the large intestine are the second most common form of cancer found in males and females. Symptoms include rectal bleeding, occult blood in stools, bowel obstruction and weight loss. Treatment is based largely on the extent of cancer penetration into the intestinal wall. Surgical cures are possible if the malignancy is confined to the intestine. Risk can be reduced when following a diet which is low in fat and high in fiber. Belongs to the dwarfin/SMAD family.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: catenin complex; cell-cell adherens junction; centrosome; cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus; plasma membrane; protein complex; transcription factor complex

Molecular Function: activin binding; beta-catenin binding; collagen binding; metal ion binding; protein binding; transcription factor activity; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; ubiquitin protein ligase binding

Biological Process: artery morphogenesis; BMP signaling pathway; negative regulation of BMP signaling pathway; negative regulation of cell migration; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein ubiquitination; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of ubiquitin-protein ligase activity; positive regulation of cell-cell adhesion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter; protein stabilization; regulation of activin receptor signaling pathway; regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; ureteric bud development; ventricular cardiac muscle morphogenesis

Disease: Colorectal Cancer, Susceptibility To, 3