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SMNDC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6348979

This protein is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a… More details

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Product Overview

Online Datasheet in PDF
Product Name
SMNDC1, Polyclonal Antibody
Full Product Name
SMNDC1, NT (SMNDC1, SMNR, SPF30, Survival of motor neuron-related-splicing factor 30, 30kD splicing factor SMNrp, SMN-related protein, Survival motor neuron domain-containing protein 1) (AP)
Product Gene Name
anti-SMNDC1 antibody
Product Synonym Names
SMNDC1; SMNR; SPF30; Survival of motor neuron-related-splicing factor 30; 30kD splicing factor SMNrp; SMN-related protein; Survival motor neuron domain-containing protein 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
238
OMIM
603519
3D Structure
ModBase 3D Structure for O75940
Immunogen
SMNDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19~48 amino acids from the N-terminal region of human SMNDC1.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-SMNDC1 antibody

Antibodies; Splicing Factors
Applications Tested/Suitable for anti-SMNDC1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SMNDC1 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-SMNDC1 antibody

Western blot analysis of SMNDC1 Antibody (N-term) in mouse kidney tissue lysates (35ug/lane). SMNDC1 (arrow) was detected using the purified Pab.
Rabbit Anti-SMNDC1 Polyclonal Antibody – Cat# MBS6348979

Flow Cytometry (FC/FACS) of anti-SMNDC1 antibody

SMNDC1 Antibody (N-term) flow cytometry analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-SMNDC1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6348979

Product References and Citations for anti-SMNDC1 antibody

Little, J.T. J. Biol. Chem. 283 (13), 8145-8152 (2008). Ewing, R.M., Mol. Syst. Biol. 3, 89 (2007). Beausoleil, S.A., Nat. Biotechnol. 24 (10), 1285-1292 (2006).

Other Notes

Small volumes of anti-SMNDC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SMNDC1 purchase

MBS6348979 is an antibody targeting SMNDC1. Also known as SMNDC1, NT (SMNDC1, SMNR, SPF30, Survival of motor neuron-related-splicing factor 30, 30kD splicing factor SMNrp, SMN-related protein, Survival motor neuron domain-containing protein 1) (AP). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SMNDC1. It may not necessarily be applicable to this product.

NCBI GI #
37087924
NCBI GeneID
10285
NCBI Accession #
O75940.1
UniProt Primary Accession #
O75940
UniProt Secondary Accession #
Q5T3K6; B2RA27; D3DRB1
UniProt Related Accession #
O75940
NCBI Official Full Name
Survival of motor neuron-related-splicing factor 30
NCBI Official Synonym Full Names
survival motor neuron domain containing 1
NCBI Official Symbol
SMNDC1
NCBI Official Synonym Symbols
SMNR; SPF30; TDRD16C
UniProt Protein Name
Survival of motor neuron-related-splicing factor 30
UniProt Synonym Protein Names
30 kDa splicing factor SMNrp; SMN-related protein; Survival motor neuron domain-containing protein 1
Protein Family
Survival of motor neuron-related-splicing factor
UniProt Gene Name
SMNDC1
UniProt Synonym Gene Names
SMNR; SPF30
UniProt Entry Name
SPF30_HUMAN
NCBI Protein Information
survival of motor neuron-related-splicing factor 30; SMN-related protein; tudor domain containing 16C; 30 kDa splicing factor SMNrp; survival motor neuron domain-containing protein 1; splicing factor 30, survival of motor neuron-related

NCBI Summary for SMNDC1

This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for SMNDC1

SPF30: Necessary for spliceosome assembly. Overexpression causes apoptosis. Belongs to the SMN family.

Protein type: Spliceosome; RNA processing; RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 10q23

Cellular Component: nucleoplasm; spliceosome; Cajal body; intermediate filament cytoskeleton; cytoplasm; nuclear speck; nucleus

Molecular Function: protein binding

Biological Process: RNA splicing, via transesterification reactions; apoptosis; RNA splicing; spliceosome assembly; mRNA processing
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Research Articles on SMNDC1

1. The binding specificity and affinity of the Tudor domains of TDRD3, SMN and SPF30 proteins were characterized quantitatively.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SMNDC1 antibody

 Reference Product  PubMed Publications
 SNRPN antibody  >2 publications with SMNDC1 and SNRPN
 PRPF3 antibody  >1 publications with SMNDC1 and PRPF3

Pathways associated with anti-SMNDC1 antibody

 Products by Pathway  Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram

Organs/Tissues associated with anti-SMNDC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with SMNDC1 and Heart
 Muscle Antibodies  >1 publications with SMNDC1 and Muscle
 Pancreas Antibodies  >1 publications with SMNDC1 and Pancreas
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