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SNAI1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6499953

MBS6499953 is an antibody targeting SNAI1. Also known as SNAI1, NT (R8) (Zinc Finger Protein SNAI1, Protein Snail Homolog 1, Protein sna, SNAI1, SNAH (APC). Reactive in Human, Mouse. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SNAI1, Polyclonal Antibody
Full Product Name
SNAI1, NT (R8) (Zinc Finger Protein SNAI1, Protein Snail Homolog 1, Protein sna, SNAI1, SNAH (APC)
Product Gene Name
anti-SNAI1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human SNAI1. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
29,083 Da
OMIM
604238
3D Structure
ModBase 3D Structure for O95863
Immunogen
Synthetic peptide selected from the N-terminal region of human SNAI1 (KLH).
Conjugate
APC
Note
Preservative Free

Product Categories/Family for anti-SNAI1 antibody

Antibodies; Transcription Factors; Zinc (Ring) Finger
Applications Tested/Suitable for anti-SNAI1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SNAI1 antibody
WB: 1:50-1:100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-SNAI1 antibody

Western blot analysis of anti-SNAI1 Antibody (N-term R8) in mouse lung tissue lysates (35ug/lane). SNAI1(arrow) was detected using the purified Pab.
Rabbit Anti-SNAI1 Polyclonal Antibody – Cat# MBS6499953

Western Blot (WB) of anti-SNAI1 antibody

Western blot analysis of SNAI1(arrow) using rabbit polyclonal SNAI1 Antibody (N-term R8). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SNAI1 gene (Lane 2) (Origene Technologies).
Rabbit Anti-SNAI1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6499953

Product References and Citations for anti-SNAI1 antibody

1. Strausberg, R.L., et al., Proc. Natl. Acad. Sci. USA 99(26):16899-16903 (2002). 2. Deloukas, P., et al., Nature 414(6866):865-871 (2001). 3. Batlle, E., et al., Nat. Cell Biol. 2(2):84-89 (2000). 4. Paznekas, W.A., et al., Genomics 62(1):42-49 (1999). 5. Twigg, S.R., et al., Hum. Genet. 105(4):320-326 (1999).

Other Notes

Small volumes of anti-SNAI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SNAI1. It may not necessarily be applicable to this product.

NCBI GI #
18765741
NCBI GeneID
6615
NCBI Accession #
NP_005976
UniProt Primary Accession #
O95863
UniProt Secondary Accession #
Q9P113; Q9UBP7; Q9UHH7; B2R842
UniProt Related Accession #
O95863
GenBank Nucleotide #
NM_005985.3
NCBI Official Full Name
zinc finger protein SNAI1
NCBI Official Synonym Full Names
snail family transcriptional repressor 1
NCBI Official Symbol
SNAI1
NCBI Official Synonym Symbols
SNA; SNAH; SNAIL; SLUGH2; SNAIL1; dJ710H13.1
UniProt Protein Name
Zinc finger protein SNAI1
UniProt Synonym Protein Names
Protein snail homolog 1
Protein Family
Protein snail
UniProt Gene Name
SNAI1
UniProt Synonym Gene Names
SNAH; Protein sna
UniProt Entry Name
SNAI1_HUMAN
NCBI Protein Information
zinc finger protein SNAI1

NCBI Summary for SNAI1

The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]
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UniProt Comments for SNAI1

Snail1: a protein of the C2H2-type zinc-finger family that regulates transcription. Involved in embryonic mesoderm formation. Plays a role in the epithelial to mesenchymal transition (EMT). EMT is characterized by decreased levels of the epithelial markers E-cadherin and alpha- and beta-catenin, and increased cellular migration and expression of the mesenchymal markers fibronectin, vimentin, N-cadherin and smooth muscle alpha-actin.E Snail binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription. NF-kappaB binds and regulates the snail promoter and is critical for EMT, and inhibition of NF-kappaB activity lowered snail levels and morphologically reversed the EMT.

Protein type: Transcription factor; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; metal ion binding; kinase binding

Biological Process: osteoblast differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; cell migration; hair follicle morphogenesis; mesoderm formation; positive regulation of transcription, DNA-dependent; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; palate development; positive regulation of cell migration
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Research Articles on SNAI1

1. PARP3 controls of TGFbeta-induced epithelial mesenchymal transformation and acquisition of stem-like cell features by stimulation transglutaminase 2/SNAI1 signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SNAI1 antibody

 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 Mesodermal Commitment Pathway antibodies  Mesodermal Commitment Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Signaling Events Mediated By Hepatocyte Growth Factor Receptor (c-Met) Pathway antibodies  Signaling Events Mediated By Hepatocyte Growth Factor Receptor (c-Met) Pathway Diagram
 TGF-B Signaling In Thyroid Cells For Epithelial-Mesenchymal Transition Pathway antibodies  TGF-B Signaling In Thyroid Cells For Epithelial-Mesenchymal Transition Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram

Diseases associated with anti-SNAI1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >71 publications with SNAI1 and Neoplasms
 Neoplasm Invasiveness Antibodies  >27 publications with SNAI1 and Neoplasm Invasiveness
 Breast Neoplasms Antibodies  >23 publications with SNAI1 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >22 publications with SNAI1 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >16 publications with SNAI1 and Lung Neoplasms
 Lung Diseases Antibodies  >15 publications with SNAI1 and Lung Diseases
 Disease Models, Animal Antibodies  >9 publications with SNAI1 and Disease Models, Animal
 Carcinoma, Squamous Cell Antibodies  >9 publications with SNAI1 and Carcinoma, Squamous Cell
 Cell Transformation, Neoplastic Antibodies  >7 publications with SNAI1 and Cell Transformation, Neoplastic
 Melanoma Antibodies  >7 publications with SNAI1 and Melanoma

Organs/Tissues associated with anti-SNAI1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >27 publications with SNAI1 and Lung
 Embryonic Tissue Antibodies  >23 publications with SNAI1 and Embryonic Tissue
 Bone Antibodies  >14 publications with SNAI1 and Bone
 Skin Antibodies  >9 publications with SNAI1 and Skin
 Vascular Antibodies  >9 publications with SNAI1 and Vascular
 Brain Antibodies  >6 publications with SNAI1 and Brain
 Blood Antibodies  >5 publications with SNAI1 and Blood
 Pancreas Antibodies  >5 publications with SNAI1 and Pancreas
 Kidney Antibodies  >4 publications with SNAI1 and Kidney
 Intestine Antibodies  >3 publications with SNAI1 and Intestine
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