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SOSTDC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6349891

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs,… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SOSTDC1, Polyclonal Antibody
Full Product Name
SOSTDC1, CT (SOSTDC1, USAG1, Sclerostin domain-containing protein 1, Ectodermal BMP inhibitor, Uterine sensitization-associated gene 1 protein) (PE)
Product Gene Name
anti-SOSTDC1 antibody
Product Synonym Names
SOSTDC1; USAG1; Sclerostin domain-containing protein 1; Ectodermal BMP inhibitor; Uterine sensitization-associated gene 1 protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
26,260 Da
OMIM
609675
3D Structure
ModBase 3D Structure for Q6X4U4
Immunogen
SOSTDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-196 amino acids from the C-terminal region of human SOSTDC1.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-SOSTDC1 antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-SOSTDC1 antibody
Western Blot (WB), FLISA
Application Notes for anti-SOSTDC1 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-SOSTDC1 antibody

SOSTDC1 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SOSTDC1 antibody detected the SOSTDC1 protein (arrow).
Rabbit Anti-SOSTDC1 Polyclonal Antibody – Cat# MBS6349891

Western Blot (WB) of anti-SOSTDC1 antibody

SOSTDC1 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the SOSTDC1 antibody detected the SOSTDC1 protein (arrow).
Rabbit Anti-SOSTDC1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6349891

Product References and Citations for anti-SOSTDC1 antibody

Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010): Ohshima, J., et al. Genes Chromosomes Cancer 48(12):1037-1050(2009). Blish, K.R., et al. Mol. Biol. Cell 19(2):457-464(2008). Lamesch, P., et al. Genomics 89(3):307-315(2007). Yanagita, M. Cytokine Growth Factor Rev. 16(3):309-317(2005).

Other Notes

Small volumes of anti-SOSTDC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SOSTDC1 purchase

MBS6349891 is an antibody targeting SOSTDC1. Also known as SOSTDC1, CT (SOSTDC1, USAG1, Sclerostin domain-containing protein 1, Ectodermal BMP inhibitor, Uterine sensitization-associated gene 1 protein) (PE). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SOSTDC1. It may not necessarily be applicable to this product.

NCBI GI #
23943785
NCBI GeneID
25928
NCBI Accession #
NP_056279.1
UniProt Primary Accession #
Q6X4U4
UniProt Secondary Accession #
Q96HJ7; Q9Y3U3; A8MUA6
UniProt Related Accession #
Q6X4U4
GenBank Nucleotide #
NM_015464.2
NCBI Official Full Name
sclerostin domain-containing protein 1
NCBI Official Synonym Full Names
sclerostin domain containing 1
NCBI Official Symbol
SOSTDC1
NCBI Official Synonym Symbols
USAG1; CDA019; ECTODIN
UniProt Protein Name
Sclerostin domain-containing protein 1
UniProt Synonym Protein Names
Ectodermal BMP inhibitor; Ectodin; Uterine sensitization-associated gene 1 protein; USAG-1
Protein Family
Sclerostin domain-containing protein
UniProt Gene Name
SOSTDC1
UniProt Synonym Gene Names
USAG1; Ectodin; USAG-1
UniProt Entry Name
SOSD1_HUMAN
NCBI Protein Information
sclerostin domain-containing protein 1; cystine-knot containing secreted protein; ectodermal BMP inhibitor; uterine sensitization-associated protein-1

UniProt Comments for SOSTDC1

SOSTDC1: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Belongs to the sclerostin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: extracellular space

Biological Process: hair follicle morphogenesis; Wnt receptor signaling pathway; pattern specification process; odontogenesis of dentine-containing teeth; negative regulation of BMP signaling pathway; negative regulation of cell fate commitment
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Research Articles on SOSTDC1

1. Unliganded VDR upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SOSTDC1 antibody

 Reference Product  PubMed Publications
 BMP4 antibody  >6 publications with SOSTDC1 and BMP4
 BMP7 antibody  >4 publications with SOSTDC1 and BMP7
 BMP2 antibody  >2 publications with SOSTDC1 and BMP2

Pathways associated with anti-SOSTDC1 antibody

 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram

Diseases associated with anti-SOSTDC1 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >12 publications with SOSTDC1 and Kidney Diseases
 Congenital Abnormalities Antibodies  >10 publications with SOSTDC1 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >6 publications with SOSTDC1 and Disease Models, Animal
 Adenocarcinoma Antibodies  >2 publications with SOSTDC1 and Adenocarcinoma
 Abnormalities, Multiple Antibodies  >2 publications with SOSTDC1 and Abnormalities, Multiple
 Inflammation Antibodies  >1 publications with SOSTDC1 and Inflammation
 Liver Diseases Antibodies  >1 publications with SOSTDC1 and Liver Diseases
 Necrosis Antibodies  >1 publications with SOSTDC1 and Necrosis
 Hypospadias Antibodies  >1 publications with SOSTDC1 and Hypospadias
 Weight Loss Antibodies  >1 publications with SOSTDC1 and Weight Loss

Organs/Tissues associated with anti-SOSTDC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >20 publications with SOSTDC1 and Embryonic Tissue
 Kidney Antibodies  >15 publications with SOSTDC1 and Kidney
 Mouth Antibodies  >14 publications with SOSTDC1 and Mouth
 Skin Antibodies  >9 publications with SOSTDC1 and Skin
 Connective Tissue Antibodies  >6 publications with SOSTDC1 and Connective Tissue
 Brain Antibodies  >4 publications with SOSTDC1 and Brain
 Uterus Antibodies  >3 publications with SOSTDC1 and Uterus
 Vascular Antibodies  >2 publications with SOSTDC1 and Vascular
 Stomach Antibodies  >1 publications with SOSTDC1 and Stomach
 Lung Antibodies  >1 publications with SOSTDC1 and Lung
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