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SPR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9403078

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+… More details

$260 / 0.05 mL +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SPR1, Polyclonal Antibody
Full Product Name
SPR1 Antibody
Product Gene Name
anti-SPR1 antibody
Product Synonym Names
Sphingosylphosphorylcholine receptor; Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total SPR1 protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
41,077 Da
OMIM
601404
3D Structure
ModBase 3D Structure for Q15743
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from internal of human SPR1.
Target Name
SPR1

Product Categories/Family for anti-SPR1 antibody

Total protein Ab
Applications Tested/Suitable for anti-SPR1 antibody
Western Blot (WB)
Application Notes for anti-SPR1 antibody
Western blotting: 1:500~1:3000

Western Blot (WB) of anti-SPR1 antibody

Western blot analysis of extracts from Jurkat cells and HeLa cells, using SPR1 antibody.
Rabbit Anti-SPR1 Polyclonal Antibody – Cat# MBS9403078

Other Notes

Small volumes of anti-SPR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPR1 purchase

MBS9403078 is an antibody targeting SPR1. Also known as SPR1 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SPR1. It may not necessarily be applicable to this product.

NCBI GI #
295054325
NCBI GeneID
8111
NCBI Accession #
NP_001171147.1
UniProt Primary Accession #
Q15743
UniProt Secondary Accession #
Q13334; Q4VBB4; Q6IX34
UniProt Related Accession #
Q15743
GenBank Nucleotide #
NM_001177676.1
NCBI Official Full Name
ovarian cancer G-protein coupled receptor 1
NCBI Official Synonym Full Names
G protein-coupled receptor 68
NCBI Official Symbol
GPR68
NCBI Official Synonym Symbols
OGR1; GPR12A
UniProt Protein Name
Ovarian cancer G-protein coupled receptor 1
UniProt Synonym Protein Names
G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor
Protein Family
Protein
UniProt Gene Name
GPR68
UniProt Synonym Gene Names
OGR1; OGR-1
UniProt Entry Name
OGR1_HUMAN
NCBI Protein Information
ovarian cancer G-protein coupled receptor 1

UniProt Comments for SPR1

GPR68: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer. Belongs to the G-protein coupled receptor 1 family.

Protein type: Tumor suppressor; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 14q31

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of monocyte differentiation; inflammatory response
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Research Articles on SPR1

1. Provide evidence for the roles of OGR1 and ASIC1a in the regulation of intestinal passive Mg(2+) absorption.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SPR1 antibody

 Reference Product  PubMed Publications
 GPR4 antibody  >24 publications with SPR1 and GPR4
 GPR65 antibody  >12 publications with SPR1 and GPR65
 GPR132 antibody  >3 publications with SPR1 and GPR132

Pathways associated with anti-SPR1 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Osteoclast Signaling Pathway antibodies  Osteoclast Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-SPR1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >14 publications with SPR1 and Inflammation
 Prostatic Diseases Antibodies  >2 publications with SPR1 and Prostatic Diseases
 Necrosis Antibodies  >2 publications with SPR1 and Necrosis
 Heart Diseases Antibodies  >1 publications with SPR1 and Heart Diseases
 Lung Injury Antibodies  >1 publications with SPR1 and Lung Injury
 Neoplasm Metastasis Antibodies  >1 publications with SPR1 and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >1 publications with SPR1 and Liver Neoplasms

Organs/Tissues associated with anti-SPR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >12 publications with SPR1 and Bone
 Blood Antibodies  >10 publications with SPR1 and Blood
 Lung Antibodies  >8 publications with SPR1 and Lung
 Connective Tissue Antibodies  >5 publications with SPR1 and Connective Tissue
 Prostate Antibodies  >5 publications with SPR1 and Prostate
 Intestine Antibodies  >3 publications with SPR1 and Intestine
 Pancreas Antibodies  >3 publications with SPR1 and Pancreas
 Brain Antibodies  >3 publications with SPR1 and Brain
 Thymus Antibodies  >1 publications with SPR1 and Thymus
 Placenta Antibodies  >1 publications with SPR1 and Placenta
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