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SRGN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9459311

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SRGN, Polyclonal Antibody
Full Product Name
SRGN Rabbit Polyclonal Antibody
Product Gene Name
anti-SRGN antibody
Product Synonym Names
SRGN; PPG; PRG; PRG1; serglycin
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purity/Purification
Affinity purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
OMIM
177040
3D Structure
ModBase 3D Structure for P10124
Immunogen
Recombinant fusion protein of human SRGN (NP_002718.2).

Product Categories/Family for anti-SRGN antibody

Primary Antibodies
Applications Tested/Suitable for anti-SRGN antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-SRGN antibody
WB: 1:500-1:2000
IF: 1:50-1:200

Western Blot (WB) of anti-SRGN antibody

Western blot analysis of extracts of various cell lines, using SRGN at 1:1000 dilution.
Rabbit Anti-SRGN Polyclonal Antibody – Cat# MBS9459311

Immunofluorescence (IF) of anti-SRGN antibody

Immunofluorescence analysis of A549 cells using SRGN. Blue: DAPI for nuclear staining.
Rabbit Anti-SRGN Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9459311

Other Notes

Small volumes of anti-SRGN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SRGN purchase

MBS9459311 is an antibody targeting SRGN. Also known as SRGN Rabbit Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SRGN. It may not necessarily be applicable to this product.

NCBI GI #
45935371
NCBI GeneID
5552
NCBI Accession #
NP_002718.2
UniProt Primary Accession #
P10124
UniProt Secondary Accession #
Q5VW06; B2R4L7
UniProt Related Accession #
P10124
GenBank Nucleotide #
NM_002727.3
NCBI Official Full Name
serglycin isoform 1
NCBI Official Synonym Full Names
serglycin
NCBI Official Symbol
SRGN
NCBI Official Synonym Symbols
PPG; PRG; PRG1
UniProt Protein Name
Serglycin
UniProt Synonym Protein Names
Hematopoietic proteoglycan core protein; Platelet proteoglycan core protein; P.PG; Secretory granule proteoglycan core protein
Protein Family
Serglycin
UniProt Gene Name
SRGN
UniProt Synonym Gene Names
PRG; PRG1; P.PG
UniProt Entry Name
SRGN_HUMAN
NCBI Protein Information
serglycin

UniProt Comments for SRGN

SRGN: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization. Belongs to the serglycin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: extracellular region; extracellular space; Golgi apparatus; mast cell granule

Molecular Function: protein binding

Biological Process: induction of apoptosis by granzyme; maintenance of granzyme B localization in T cell secretory granule; maintenance of protease localization in mast cell secretory granule; mast cell secretory granule organization and biogenesis; negative regulation of bone mineralization; negative regulation of cytokine secretion; platelet degranulation; protease localization in mast cell secretory granule; protein processing; T cell secretory granule organization and biogenesis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SRGN antibody

 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with anti-SRGN antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4 publications with SRGN and Carcinoma
 Liver Neoplasms Antibodies  >2 publications with SRGN and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with SRGN and Liver Diseases
 Adenocarcinoma Antibodies  >2 publications with SRGN and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >2 publications with SRGN and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with SRGN and Carcinoma, Hepatocellular
 Pain Antibodies  >1 publications with SRGN and Pain
 Nervous System Diseases Antibodies  >1 publications with SRGN and Nervous System Diseases
 Disease Models, Animal Antibodies  >1 publications with SRGN and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with SRGN and Kidney Diseases

Organs/Tissues associated with anti-SRGN antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with SRGN and Blood
 Muscle Antibodies  >2 publications with SRGN and Muscle
 Liver Antibodies  >2 publications with SRGN and Liver
 Nerve Antibodies  >1 publications with SRGN and Nerve
 Bone Antibodies  >1 publications with SRGN and Bone
 Uterus Antibodies  >1 publications with SRGN and Uterus
 Kidney Antibodies  >1 publications with SRGN and Kidney
 Brain Antibodies  >1 publications with SRGN and Brain
 Lung Antibodies  >1 publications with SRGN and Lung
 Vascular Antibodies  >1 publications with SRGN and Vascular
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