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STX2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9208413

The product of this gene belongs to thesyntaxin/epimorphin family of proteins. The syntaxins are a largeprotein family implicated in the targeting and fusion ofintracellular transport vesicles. The product of this generegulates epithelial-mesenchymal… More details

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Product Overview

Online Datasheet in PDF
Product Name
STX2, Polyclonal Antibody
Full Product Name
STX2 Antibody (Center)
Product Gene Name
anti-STX2 antibody
Product Synonym Names
Syntaxin-2; Epimorphin; STX2; EPIM; STX2A; STX2B; STX2C
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.37 (lot specific)
Specificity
This STX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-152 amino acids from the Central region of human STX2.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
STX2 peptide (MBS9219154) is used for blocking the activity of STX2 antibody (MBS9208413)
Molecular Weight
33341
Immunogen Sequence Positions
123-152
OMIM
132350
3D Structure
ModBase 3D Structure for P32856
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN

Product Categories/Family for anti-STX2 antibody

Cancer; Neuroscience; Signal transduction
Applications Tested/Suitable for anti-STX2 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-STX2 antibody
WB~~1:1000

Western Blot (WB) of anti-STX2 antibody

STX2 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the STX2 antibody detected the STX2 protein (arrow).
Rabbit Anti-STX2 Polyclonal Antibody – Cat# MBS9208413

Immunohistochemistry (IHC) of anti-STX2 antibody

STX2 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of STX2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-STX2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9208413

Western Blot (WB) of anti-STX2 antibody

STX2 Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the STX2 antibody detected the STX2 protein (arrow).
Rabbit Anti-STX2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9208413

Product References and Citations for anti-STX2 antibody

Chen, C.S., et al. J. Biol. Chem. 284(11):6877-6884(2009)
Okugawa, Y., et al. J. Invest. Dermatol. 128(8):1884-1893(2008)
Flaumenhaft, R., et al. Blood 110(5):1492-1501(2007)
Low, S.H., et al. Mol. Biol. Cell 17(2):977-989(2006)
Band, A.M., et al. BMC Cell Biol. 6 (1), 26 (2005) :

Other Notes

Small volumes of anti-STX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STX2 purchase

MBS9208413 is an antibody targeting STX2. Also known as STX2 Antibody (Center). Reactive in Human, mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STX2. It may not necessarily be applicable to this product.

NCBI GI #
37577287
NCBI GeneID
2054
NCBI Accession #
NP_001971.2
NCBI Related Accession #
NP_919337.1
UniProt Primary Accession #
P32856
UniProt Secondary Accession #
Q86VW8
UniProt Related Accession #
P32856
GenBank Nucleotide #
NM_001980.3
NCBI Official Full Name
syntaxin-2 isoform 1
NCBI Official Synonym Full Names
syntaxin 2
NCBI Official Symbol
STX2
NCBI Official Synonym Symbols
EPM; EPIM; STX2A; STX2B; STX2C
UniProt Protein Name
Syntaxin-2
UniProt Synonym Protein Names
Epimorphin
Protein Family
Syntaxin
UniProt Gene Name
STX2
UniProt Synonym Gene Names
EPIM; STX2A; STX2B; STX2C
UniProt Entry Name
STX2_HUMAN
NCBI Protein Information
syntaxin-2

NCBI Summary for STX2

The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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UniProt Comments for STX2

STX2: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. Belongs to the syntaxin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: SNARE complex; extracellular space; synaptic vesicle; cell surface; intracellular membrane-bound organelle; lamellipodium; basolateral plasma membrane; integral to membrane; plasma membrane; endomembrane system; intercellular junction; lipid raft

Molecular Function: protein dimerization activity; SNAP receptor activity; protein binding; SNARE binding; calcium-dependent protein binding

Biological Process: synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; organ morphogenesis; response to hydroperoxide; vesicle docking; regulation of blood coagulation; acrosome reaction; ectoderm development; signal transduction; cell differentiation; protein oligomerization; regulation of cytoskeleton organization and biogenesis
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Research Articles on STX2

1. Identify 3 loci associated with circulating tPA levels, the PLAT region, STXBP5, and STX2. Functional studies implicate a novel role for STXBP5 and STX2 in regulating tPA release.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STX2 antibody

 Reference Product  PubMed Publications
 VAMP8 antibody  >1 publications with STX2 and VAMP8
 VAMP2 antibody  >1 publications with STX2 and VAMP2
 SNAP23 antibody  >1 publications with STX2 and SNAP23

Pathways associated with anti-STX2 antibody

 Products by Pathway  Pathway Diagram
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Diseases associated with anti-STX2 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >148 publications with STX2 and Kidney Diseases
 Necrosis Antibodies  >30 publications with STX2 and Necrosis
 Inflammation Antibodies  >23 publications with STX2 and Inflammation
 Edema Antibodies  >19 publications with STX2 and Edema
 Acute Kidney Injury Antibodies  >14 publications with STX2 and Acute Kidney Injury
 Cardiovascular Diseases Antibodies  >13 publications with STX2 and Cardiovascular Diseases
 Hemorrhage Antibodies  >13 publications with STX2 and Hemorrhage
 Weight Loss Antibodies  >13 publications with STX2 and Weight Loss
 Fibrosis Antibodies  >5 publications with STX2 and Fibrosis
 Heart Diseases Antibodies  >5 publications with STX2 and Heart Diseases

Organs/Tissues associated with anti-STX2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >133 publications with STX2 and Blood
 Kidney Antibodies  >89 publications with STX2 and Kidney
 Intestine Antibodies  >80 publications with STX2 and Intestine
 Brain Antibodies  >35 publications with STX2 and Brain
 Liver Antibodies  >14 publications with STX2 and Liver
 Lung Antibodies  >13 publications with STX2 and Lung
 Nerve Antibodies  >9 publications with STX2 and Nerve
 Heart Antibodies  >8 publications with STX2 and Heart
 Embryonic Tissue Antibodies  >7 publications with STX2 and Embryonic Tissue
 Muscle Antibodies  >6 publications with STX2 and Muscle
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