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TACC3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9402002

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors By similarity. May be involved in the control of cell… More details

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Product Overview

Online Datasheet in PDF
Product Name
TACC3, Polyclonal Antibody
Full Product Name
TACC3 Antibody
Product Gene Name
anti-TACC3 antibody
Product Synonym Names
ERIC-1; ERIC1; TAC3; Transforming acidic coiled-coil-containing protein 3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total TACC3 protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
90,360 Da
OMIM
605303
3D Structure
ModBase 3D Structure for Q9Y6A5
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from C-terminal of human TACC3.
Target Name
TACC3

Product Categories/Family for anti-TACC3 antibody

Total protein Ab
Applications Tested/Suitable for anti-TACC3 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TACC3 antibody
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Western Blot (WB) of anti-TACC3 antibody

Western blot analysis of extracts from 293 cells and HUVEC cells, using TACC3 antibody.
Rabbit Anti-TACC3 Polyclonal Antibody – Cat# MBS9402002

Immunohistochemistry (IHC) of anti-TACC3 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using TACC3 antibody.
Rabbit Anti-TACC3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9402002

Immunofluorescence (IF) of anti-TACC3 antibody

Immunofluorescence analysis of A549cells, using TACC3 antibody.
Rabbit Anti-TACC3 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9402002

Other Notes

Small volumes of anti-TACC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TACC3 purchase

MBS9402002 is an antibody targeting TACC3. Also known as TACC3 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TACC3. It may not necessarily be applicable to this product.

NCBI GI #
5454102
NCBI GeneID
10460
NCBI Accession #
NP_006333.1
UniProt Primary Accession #
Q9Y6A5
UniProt Secondary Accession #
Q2NKK4; Q3KQS5; Q9UMQ1
UniProt Related Accession #
Q9Y6A5
GenBank Nucleotide #
NM_006342.2
NCBI Official Full Name
transforming acidic coiled-coil-containing protein 3
NCBI Official Synonym Full Names
transforming, acidic coiled-coil containing protein 3
NCBI Official Symbol
TACC3
NCBI Official Synonym Symbols
ERIC1; ERIC-1
UniProt Protein Name
Transforming acidic coiled-coil-containing protein 3
UniProt Synonym Protein Names
ERIC-1
Protein Family
Transforming acidic coiled-coil-containing protein
UniProt Gene Name
TACC3
UniProt Synonym Gene Names
ERIC1
UniProt Entry Name
TACC3_HUMAN
NCBI Protein Information
transforming acidic coiled-coil-containing protein 3

NCBI Summary for TACC3

This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
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UniProt Comments for TACC3

TACC3: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May be involved in the control of cell growth and differentiation. May contribute to cancer. Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2. Interacts with GCN5L2 and PCAF. Up-regulated in various cancer cell lines. Belongs to the TACC family.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: centrosome; cytoplasm

Molecular Function: protein domain specific binding; protein binding

Biological Process: cell proliferation; regulation of microtubule-based process; cytoplasmic sequestering of transcription factor; astral microtubule organization and biogenesis; neurogenesis; regulation of cell cycle; response to hypoxia; hemopoiesis; cerebral cortex development; microtubule cytoskeleton organization and biogenesis; interkinetic nuclear migration

Disease: Bladder Cancer
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Research Articles on TACC3

1. TACC3 depletion induces G1 arrest and cell death by activating p38-p53-p21 signaling and triggering a centrosome-mediated cellular stress response.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TACC3 antibody

 Reference Product  PubMed Publications
 CKAP5 antibody  >13 publications with TACC3 and CKAP5
 AURKA antibody  >11 publications with TACC3 and AURKA
 AURKB antibody  >3 publications with TACC3 and AURKB
 ILK antibody  >3 publications with TACC3 and ILK
 NDEL1 antibody  >2 publications with TACC3 and NDEL1
 FAM161B antibody  >1 publications with TACC3 and FAM161B
 UBC antibody  >1 publications with TACC3 and UBC
 CDK1 antibody  >1 publications with TACC3 and CDK1

Pathways associated with anti-TACC3 antibody

 Products by Pathway  Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram

Diseases associated with anti-TACC3 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >9 publications with TACC3 and Adenocarcinoma
 Lung Neoplasms Antibodies  >8 publications with TACC3 and Lung Neoplasms
 Urinary Bladder Neoplasms Antibodies  >8 publications with TACC3 and Urinary Bladder Neoplasms
 Neoplasms, Experimental Antibodies  >6 publications with TACC3 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >6 publications with TACC3 and Breast Neoplasms
 Nervous System Diseases Antibodies  >6 publications with TACC3 and Nervous System Diseases
 Lung Diseases Antibodies  >6 publications with TACC3 and Lung Diseases
 Cardiovascular Diseases Antibodies  >4 publications with TACC3 and Cardiovascular Diseases
 Congenital Abnormalities Antibodies  >3 publications with TACC3 and Congenital Abnormalities
 Liver Neoplasms Antibodies  >2 publications with TACC3 and Liver Neoplasms

Organs/Tissues associated with anti-TACC3 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >13 publications with TACC3 and Lung
 Brain Antibodies  >10 publications with TACC3 and Brain
 Bladder Antibodies  >10 publications with TACC3 and Bladder
 Liver Antibodies  >6 publications with TACC3 and Liver
 Testis Antibodies  >5 publications with TACC3 and Testis
 Blood Antibodies  >4 publications with TACC3 and Blood
 Ovary Antibodies  >4 publications with TACC3 and Ovary
 Bone Antibodies  >4 publications with TACC3 and Bone
 Thymus Antibodies  >4 publications with TACC3 and Thymus
 Spleen Antibodies  >3 publications with TACC3 and Spleen
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