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TAF3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6353381

The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TAF3, Polyclonal Antibody
Full Product Name
TAF3, CT (TAF3, Transcription initiation factor TFIID subunit 3, 140kD TATA box-binding protein-associated factor, TBP-associated factor 3, Transcription initiation factor TFIID 140kD subunit) (APC)
Product Gene Name
anti-TAF3 antibody
Product Synonym Names
TAF3; Transcription initiation factor TFIID subunit 3; 140kD TATA box-binding protein-associated factor; TBP-associated factor 3; Transcription initiation factor TFIID 140kD subunit
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
103,582 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (7860673..8056714). Location: 10p15.1
OMIM
606576
3D Structure
ModBase 3D Structure for Q5VWG9
Immunogen
TAF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613~643 amino acids from the C-terminal region of human TAF3.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-TAF3 antibody

Antibodies; Transcription Factors
Applications Tested/Suitable for anti-TAF3 antibody
Western Blot (WB), FLISA
Application Notes for anti-TAF3 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-TAF3 antibody

Western blot analysis of TAF3 Antibody (C-term) in NIH-3T3 cell line lysates (35ug/lane). TAF3 (arrow) was detected using the purified Pab.
Rabbit Anti-TAF3 Polyclonal Antibody – Cat# MBS6353381

Product References and Citations for anti-TAF3 antibody

Trynka, G., et al. Gut 58(8):1078-1083(2009). Luke, M.M., et al. Stroke 40(2):363-368(2009). Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008).

Other Notes

Small volumes of anti-TAF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAF3 purchase

MBS6353381 is an antibody targeting TAF3. Also known as TAF3, CT (TAF3, Transcription initiation factor TFIID subunit 3, 140kD TATA box-binding protein-associated factor, TBP-associated factor 3, Transcription initiation factor TFIID 140kD subunit) (APC). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TAF3. It may not necessarily be applicable to this product.

NCBI GI #
151301171
NCBI GeneID
83860
NCBI Accession #
NP_114129.1
UniProt Primary Accession #
Q5VWG9
UniProt Secondary Accession #
Q05DA0; Q6GMS5; Q6P6B5; Q86VY6; Q9BQS9; Q9UFI8
UniProt Related Accession #
Q5VWG9
GenBank Nucleotide #
NM_031923.3
NCBI Official Full Name
transcription initiation factor TFIID subunit 3
NCBI Official Synonym Full Names
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
NCBI Official Symbol
TAF3
NCBI Official Synonym Symbols
TAF140; TAFII140; TAFII-140
UniProt Protein Name
Transcription initiation factor TFIID subunit 3
UniProt Synonym Protein Names
140 kDa TATA box-binding protein-associated factor; TBP-associated factor 3; Transcription initiation factor TFIID 140 kDa subunit
Protein Family
Transcription initiation factor
UniProt Gene Name
TAF3
UniProt Synonym Gene Names
TAF(II)140; TAF140; TAFII-140; TAFII140
UniProt Entry Name
TAF3_HUMAN
NCBI Protein Information
transcription initiation factor TFIID subunit 3; TAF(II)140; TBP-associated factor 3; RNA polymerase II transcription factor TAFII140; 140 kDa TATA box-binding protein-associated factor; transcription initiation factor TFIID 140 kDa subunit

UniProt Comments for TAF3

TAF140: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. Belongs to the TAF3 family.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 10p15.1

Cellular Component: nucleoplasm; transcription factor TFIID complex; nucleus

Molecular Function: protein binding; zinc ion binding; p53 binding

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; negative regulation of transcription factor activity; RNA elongation from RNA polymerase II promoter; gene expression; negative regulation of transcription from RNA polymerase II promoter; maintenance of protein localization in nucleus
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Research Articles on TAF3

1. Study shows that H3K4me3-TAF3 interactions direct global TFIID recruitment to active genes, some of which are p53 targets. Further analyses show that H3K4me3 enhances p53-dependent transcription by stimulating preinitiation complex formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TAF3 antibody

 Reference Product  PubMed Publications
 TAF10 antibody  >2 publications with TAF3 and TAF10

Pathways associated with anti-TAF3 antibody

 Products by Pathway  Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram

Diseases associated with anti-TAF3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with TAF3 and Neoplasms
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