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TGFB1I1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6001461

This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TGFB1I1, Polyclonal Antibody
Full Product Name
TGFB1I1 (ARA55, Transforming Growth Factor beta-1-induced Transcript 1 Protein, Androgen Receptor Coactivator 55kD Protein, Androgen Receptor-associated Protein of 55kD, Hydrogen Peroxide-inducible Clone 5 Protein)
Product Gene Name
anti-Tgfb1i1 antibody
Product Synonym Names
Anti -TGFB1I1 (ARA55, Transforming Growth Factor beta-1-induced Transcript 1 Protein, Androgen Receptor Coactivator 55kD Protein, Androgen Receptor-associated Protein of 55kD, Hydrogen Peroxide-inducible Clone 5 Protein)
Immunogen Sequence
MPRSGAPKER PAEPLTPPPS YGHQPQTGSG ESSGASGDKD HLYSTVCKPR SPKPAAPAAP PFSSSSGVLG TGLCELDRLL QELNATQFNI TDEIMSQFPS SKVASGEQKE DQSEDKKRPS LPSSPSPGLP KASATSATLE LDRLMASLSD FRVQNHLPAS GPTQPPVVSS TNEGSPSPPE PTGKGSLDTM LGLLQSDLSR RGVPTQAKGL CGSCNKPIAG QVVTALGRAW HPEHFVCGGC STALGGSSFF EKDGAPFCPE CYFERFSPRC GFCNQPIRHK MVTALGTHWH PEHFCCVSCG EPFGDEGFHE REGRPYCRRD FLQLFAPRCQ GCQGPILDNY ISALSALWHP DCFVCRECFA PFSGGSFFEH EGRPLCENHF HARRGSLCAT CGLPVTGRCV SALGRRFHPD HFTCTFCLRP LTKGSFQERA GKPYCQPCFL KLFG
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human TGFB1I1. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
50,101 Da
Chromosome Location
Chromosome: 7; NC_000073.6 (128246871..128253712). Location: 7; 7 F1-F3
3D Structure
ModBase 3D Structure for Q62219
Immunogen
Full length human TGFB1I1, aa1-444 (NP_057011.2).

Product Categories/Family for anti-Tgfb1i1 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-Tgfb1i1 antibody
Western Blot (WB)
Application Notes for anti-Tgfb1i1 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-Tgfb1i1 antibody

TGFB1I1 rabbit polyclonal antibody. Western Blot analysis of TGFB1I1 expression in human pancreas.
Rabbit Anti-TGFB1I1 Polyclonal Antibody – Cat# MBS6001461

Western Blot (WB) of anti-Tgfb1i1 antibody

TGFB1I1 rabbit polyclonal antibody. Western Blot analysis of TGFB1I1 expression in mouse stomach.
Rabbit Anti-TGFB1I1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6001461

Western Blot (WB) of anti-Tgfb1i1 antibody

Western Blot analysis of TGFB1I1 expression in transfected 293T cell line by TGFB1I1 polyclonal antibody. Lane 1: TGFB1I1 transfected lysate (47.9kD). Lane 2: Non-transfected lysate.
Rabbit Anti-TGFB1I1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6001461

Other Notes

Small volumes of anti-Tgfb1i1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tgfb1i1 purchase

MBS6001461 is an antibody targeting Tgfb1i1. Also known as TGFB1I1 (ARA55, Transforming Growth Factor beta-1-induced Transcript 1 Protein, Androgen Receptor Coactivator 55kD Protein, Androgen Receptor-associated Protein of 55kD, Hydrogen Peroxide-inducible Clone 5 Protein). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Tgfb1i1. It may not necessarily be applicable to this product.

NCBI GI #
6678313
NCBI GeneID
21804
NCBI Accession #
NP_033391.1
UniProt Primary Accession #
Q62219
UniProt Secondary Accession #
Q3YBY7; Q3YBY8; Q3YBZ0; Q3YBZ1; Q3YBZ3; Q3YBZ4; Q3YBZ5; Q3YBZ6
UniProt Related Accession #
Q62219
GenBank Nucleotide #
NM_009365.2
NCBI Official Full Name
transforming growth factor beta-1-induced transcript 1 protein
NCBI Official Synonym Full Names
transforming growth factor beta 1 induced transcript 1
NCBI Official Symbol
Tgfb1i1
NCBI Official Synonym Symbols
Hic5; ARA55; TSC-5; hic-5
UniProt Protein Name
Transforming growth factor beta-1-induced transcript 1 protein
UniProt Synonym Protein Names
Androgen receptor-associated protein of 55 kDa; Hydrogen peroxide-inducible clone 5 protein; Hic-5; TGF beta-stimulated clone 5
Protein Family
Transforming growth factor beta-1-induced transcript 1 protein
UniProt Gene Name
Tgfb1i1
UniProt Synonym Gene Names
Ara55; Hic-5; TSC-5
UniProt Entry Name
TGFI1_MOUSE
NCBI Protein Information
transforming growth factor beta-1-induced transcript 1 protein; TGF beta-stimulated clone 5; hydrogen peroxide-inducible clone 5 protein; androgen receptor-associated protein of 55 kDa

UniProt Comments for Tgfb1i1

Hic-5: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin. Up-regulated by TNF and hydrogen peroxide. Expressed in platelets, smooth muscle and prostate stromal cells. Belongs to the paxillin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Motility/polarity/chemotaxis

Cellular Component: extracellular matrix; focal adhesion; cytoskeleton; cytoplasm; intracellular; nucleus; cell junction

Molecular Function: protein binding; Roundabout binding; androgen receptor binding; zinc ion binding; metal ion binding; transcription coactivator activity

Biological Process: morphogenesis of embryonic epithelium; cell fate commitment; Wnt receptor signaling pathway; epithelial cell differentiation; response to heat; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; ubiquitin-dependent SMAD protein catabolic process; negative regulation of fat cell differentiation
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Research Articles on Tgfb1i1

1. Hic-5 is expressed in B16-F1 murine melanoma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Tgfb1i1 antibody

 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram

Diseases associated with anti-Tgfb1i1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >30 publications with Tgfb1i1 and Neoplasms
 Fibrosis Antibodies  >5 publications with Tgfb1i1 and Fibrosis
 Disease Models, Animal Antibodies  >5 publications with Tgfb1i1 and Disease Models, Animal
 Necrosis Antibodies  >5 publications with Tgfb1i1 and Necrosis
 Cardiovascular Diseases Antibodies  >4 publications with Tgfb1i1 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >3 publications with Tgfb1i1 and Kidney Diseases
 Neoplasm Metastasis Antibodies  >3 publications with Tgfb1i1 and Neoplasm Metastasis
 Thrombosis Antibodies  >3 publications with Tgfb1i1 and Thrombosis
 Neoplasms, Experimental Antibodies  >2 publications with Tgfb1i1 and Neoplasms, Experimental
 Hypertrophy Antibodies  >2 publications with Tgfb1i1 and Hypertrophy

Organs/Tissues associated with anti-Tgfb1i1 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >25 publications with Tgfb1i1 and Prostate
 Muscle Antibodies  >20 publications with Tgfb1i1 and Muscle
 Kidney Antibodies  >8 publications with Tgfb1i1 and Kidney
 Embryonic Tissue Antibodies  >6 publications with Tgfb1i1 and Embryonic Tissue
 Lung Antibodies  >4 publications with Tgfb1i1 and Lung
 Heart Antibodies  >4 publications with Tgfb1i1 and Heart
 Brain Antibodies  >3 publications with Tgfb1i1 and Brain
 Thyroid Antibodies  >2 publications with Tgfb1i1 and Thyroid
 Intestine Antibodies  >1 publications with Tgfb1i1 and Intestine
 Spleen Antibodies  >1 publications with Tgfb1i1 and Spleen
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