• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TIMP4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6355654

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein… More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TIMP4, Polyclonal Antibody
Full Product Name
TIMP4, ID (TIMP4, Metalloproteinase inhibitor 4, Tissue inhibitor of metalloproteinases 4) (MaxLight 650)
Product Gene Name
anti-TIMP4 antibody
Product Synonym Names
TIMP4; Metalloproteinase inhibitor 4; Tissue inhibitor of metalloproteinases 4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
25,503 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (12194568..12200851, complement). Location: 3p25
OMIM
601915
3D Structure
ModBase 3D Structure for Q99727
Immunogen
TIMP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-82 amino acids from the Central region of human TIMP4.
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-TIMP4 antibody

Antibodies; Matrix Metalloproteinases
Applications Tested/Suitable for anti-TIMP4 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-TIMP4 antibody
IHC: 1:50-100
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-TIMP4 antibody

Nalpas, B., et al. Gut 59(8):1120-1126(2010). Bailey, S.D., et al. Diabetes Care (2010). In press: Wojciechowski, R., et al. Invest. Ophthalmol. Vis. Sci. (2010). In press: Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Liss, M., et al. Am. J. Pathol. 175(3):940-946(2009).

Other Notes

Small volumes of anti-TIMP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TIMP4 purchase

MBS6355654 is an antibody targeting TIMP4. Also known as TIMP4, ID (TIMP4, Metalloproteinase inhibitor 4, Tissue inhibitor of metalloproteinases 4) (MaxLight 650). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TIMP4. It may not necessarily be applicable to this product.

NCBI GI #
4507515
NCBI GeneID
7079
NCBI Accession #
NP_003247.1
UniProt Primary Accession #
Q99727
UniProt Secondary Accession #
B2R7K6
UniProt Related Accession #
Q99727
GenBank Nucleotide #
NM_003256.3
NCBI Official Full Name
metalloproteinase inhibitor 4
NCBI Official Synonym Full Names
TIMP metallopeptidase inhibitor 4
NCBI Official Symbol
TIMP4
UniProt Protein Name
Metalloproteinase inhibitor 4
UniProt Synonym Protein Names
Tissue inhibitor of metalloproteinases 4
Protein Family
Metalloproteinase inhibitor
UniProt Gene Name
TIMP4
UniProt Synonym Gene Names
TIMP-4
UniProt Entry Name
TIMP4_HUMAN
NCBI Protein Information
metalloproteinase inhibitor 4; TIMP-4; tissue inhibitor of metalloproteinase 4; tissue inhibitor of metalloproteinases 4

UniProt Comments for TIMP4

TIMP4: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: extracellular space; proteinaceous extracellular matrix; sarcomere

Molecular Function: metalloendopeptidase inhibitor activity; protease binding; metal ion binding

Biological Process: response to drug; response to peptide hormone stimulus; negative regulation of metalloenzyme activity; ovulation cycle; central nervous system development; response to cytokine stimulus; response to hormone stimulus; response to lipopolysaccharide; negative regulation of membrane protein ectodomain proteolysis
Show more

Research Articles on TIMP4

1. Heterogeneous methylation in the promoter region of TIMP4 was associated with cancer progression in non-small cell lung cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TIMP4 antibody

 Reference Product  PubMed Publications
 MMP2 antibody  >15 publications with TIMP4 and MMP2
 MMP14 antibody  >5 publications with TIMP4 and MMP14

Pathways associated with anti-TIMP4 antibody

 Products by Pathway  Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram

Diseases associated with anti-TIMP4 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >17 publications with TIMP4 and Cardiovascular Diseases
 Neoplasms Antibodies  >12 publications with TIMP4 and Neoplasms
 Inflammation Antibodies  >8 publications with TIMP4 and Inflammation
 Skin Diseases Antibodies  >6 publications with TIMP4 and Skin Diseases
 Fibrosis Antibodies  >6 publications with TIMP4 and Fibrosis
 Necrosis Antibodies  >5 publications with TIMP4 and Necrosis
 Hypertrophy Antibodies  >4 publications with TIMP4 and Hypertrophy
 Atherosclerosis Antibodies  >4 publications with TIMP4 and Atherosclerosis
 Lung Neoplasms Antibodies  >3 publications with TIMP4 and Lung Neoplasms
 Arteriosclerosis Antibodies  >3 publications with TIMP4 and Arteriosclerosis

Organs/Tissues associated with anti-TIMP4 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >12 publications with TIMP4 and Heart
 Vascular Antibodies  >10 publications with TIMP4 and Vascular
 Lung Antibodies  >7 publications with TIMP4 and Lung
 Connective Tissue Antibodies  >5 publications with TIMP4 and Connective Tissue
 Bone Antibodies  >5 publications with TIMP4 and Bone
 Brain Antibodies  >5 publications with TIMP4 and Brain
 Embryonic Tissue Antibodies  >4 publications with TIMP4 and Embryonic Tissue
 Liver Antibodies  >2 publications with TIMP4 and Liver
 Adipose Tissue Antibodies  >2 publications with TIMP4 and Adipose Tissue
 Larynx Antibodies  >1 publications with TIMP4 and Larynx
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000