Rabbit Anti-TLK2 Polyclonal Antibody – Cat# MBS9245442

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

TLK2 Antibody – Rabbit Polyclonal

Name: TLK2 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9245442
Price: 475 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9245442

Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A… More details

$475 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TLK2, Polyclonal Antibody

Full Product Name

TLK2 Polyclonal Antibody

Product Gene Name

anti-TLK2 antibody

Product Synonym Names

TLK2; Serine/threonine-protein kinase tousled-like 2; HsHPK; PKU-alpha; Tousled-like kinase 2

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

87,661 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (60556386..60692842). Location: 17q23

OMIM

608439

3D Structure

ModBase 3D Structure for Q86UE8

Applications Tested/Suitable for anti-TLK2 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-TLK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLK2 purchase

MBS9245442 is an antibody targeting TLK2. Also known as TLK2 Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TLK2. It may not necessarily be applicable to this product.

NCBI GI #

162951881

NCBI GeneID

11011

NCBI Accession #

NP_001106178.1

UniProt Primary Accession #

Q86UE8

UniProt Secondary Accession #

Q9UKI7; Q9Y4F7; D3DU07

UniProt Related Accession #

Q86UE8

GenBank Nucleotide #

NM_001112707.1

NCBI Official Full Name

serine/threonine-protein kinase tousled-like 2 isoform B

NCBI Official Synonym Full Names

tousled-like kinase 2

NCBI Official Symbol

TLK2

NCBI Official Synonym Symbols

HsHPK; PKU-ALPHA

UniProt Protein Name

Serine/threonine-protein kinase tousled-like 2

UniProt Synonym Protein Names

HsHPK; PKU-alpha; Tousled-like kinase 2

Protein Family

Serine/threonine-protein kinase tousled

UniProt Gene Name

TLK2

UniProt Entry Name

TLK2_HUMAN

NCBI Protein Information

serine/threonine-protein kinase tousled-like 2; serine/threonine kinase

NCBI Summary for TLK2

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM, Apr 2004]

UniProt Comments for TLK2

TLK2: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; TLK family

Chromosomal Location of Human Ortholog: 17q23

Cellular Component: perinuclear region of cytoplasm; intermediate filament; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: negative regulation of autophagy; peptidyl-serine phosphorylation; regulation of chromatin assembly or disassembly; chromatin modification; cell cycle; protein amino acid phosphorylation; response to DNA damage stimulus; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; chromosome segregation

Research Articles on TLK2

1. TLKs appear to be intimately linked to the pattern of resistance to DNA damage, and specifically double-strand breaks.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TLK2 antibody

Reference Product	PubMed Publications
TLK1 antibody	>4 publications with TLK2 and TLK1

Pathways associated with anti-TLK2 antibody

Products by Pathway	Pathway Diagram
DNA Damage Response Pathway antibodies	DNA Damage Response Pathway Diagram

Diseases associated with anti-TLK2 antibody

Disease Name	Pubmed Publications
Infertility, Male Antibodies	>1 publications with TLK2 and Infertility, Male
Prostatic Diseases Antibodies	>1 publications with TLK2 and Prostatic Diseases
Abnormalities, Multiple Antibodies	>1 publications with TLK2 and Abnormalities, Multiple

Organs/Tissues associated with anti-TLK2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with TLK2 and Brain
Blood Antibodies	>1 publications with TLK2 and Blood
Prostate Antibodies	>1 publications with TLK2 and Prostate
Connective Tissue Antibodies	>1 publications with TLK2 and Connective Tissue
Testis Antibodies	>1 publications with TLK2 and Testis