TLR7 Antibody – Rabbit Polyclonal

TLR7: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral

Cellular Component: membrane; endoplasmic reticulum; lysosome; cytoplasm; plasma membrane; integral to membrane; cytoplasmic vesicle; endosome; receptor complex

Molecular Function: protein binding; single-stranded RNA binding; siRNA binding; transmembrane receptor activity; double-stranded RNA binding; drug binding

Biological Process: regulation of protein amino acid phosphorylation; immune system process; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; microglial cell activation; positive regulation of NF-kappaB import into nucleus; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 7 signaling pathway; signal transduction; positive regulation of chemokine production; positive regulation of interleukin-8 production; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; immune response; inflammatory response; I-kappaB phosphorylation; defense response to virus; positive regulation of interferon-gamma biosynthetic process