Rabbit Anti-TNNT2 Polyclonal Antibody – Cat# MBS6357241

TNNT2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the TNNT2 antibody detected the TNNT2 protein (arrow).

TNNT2 Antibody – Rabbit Polyclonal

Name: TNNT2 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6357241
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6357241

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration.… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TNNT2, Polyclonal Antibody

Full Product Name

TNNT2, ID (TNNT2, Troponin T, cardiac muscle, Cardiac muscle troponin T) (AP)

Product Gene Name

anti-TNNT2 antibody

Product Synonym Names

TNNT2; Troponin T; cardiac muscle; Cardiac muscle troponin T

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

35,924 Da

OMIM

115195

3D Structure

ModBase 3D Structure for P45379

Immunogen

TNNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-201 amino acids from the Central region of human TNNT2.

Conjugate

Note

Preservative Free

Product Categories/Family for anti-TNNT2 antibody

Antibodies; Cardiac Markers

Applications Tested/Suitable for anti-TNNT2 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-TNNT2 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-TNNT2 antibody

Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010): Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Millat, G., et al. Eur J Med Genet 53(5):261-267(2010). Watt, K.D., et al. Liver Transpl. 16(8):990-998(2010). Koide, K., et al. Heart Vessels 25(3):217-222(2010).

Other Notes

Small volumes of anti-TNNT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNNT2 purchase

MBS6357241 is an antibody targeting TNNT2. Also known as TNNT2, ID (TNNT2, Troponin T, cardiac muscle, Cardiac muscle troponin T) (AP). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNNT2. It may not necessarily be applicable to this product.

NCBI GI #

48255881

NCBI GeneID

7139

NCBI Accession #

NP_001001431.1

NCBI Related Accession #

NP_001001430.1

UniProt Primary Accession #

P45379

UniProt Secondary Accession #

O60214; Q99596; Q99597; Q9BUF6; Q9UM96; A2TDB9; A8K3K6

UniProt Related Accession #

P45379

GenBank Nucleotide #

NM_001001431.2

NCBI Official Full Name

troponin T, cardiac muscle isoform 3

NCBI Official Synonym Full Names

troponin T type 2 (cardiac)

NCBI Official Symbol

TNNT2

NCBI Official Synonym Symbols

CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6

UniProt Protein Name

Troponin T, cardiac muscle

UniProt Synonym Protein Names

Cardiac muscle troponin T

Protein Family

Troponin

UniProt Gene Name

TNNT2

UniProt Synonym Gene Names

TnTc; cTnT

UniProt Entry Name

TNNT2_HUMAN

NCBI Protein Information

troponin T, cardiac muscle; troponin T2, cardiac; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant)

UniProt Comments for TNNT2

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament

Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding

Biological Process: positive regulation of ATPase activity; regulation of muscle contraction; atrial cardiac muscle morphogenesis; metabolic process; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2

Research Articles on TNNT2

1. Familial hypertrophic cardiomyopathy mutants cTnI R145G and cTnT R278C were tested alone and together in motility assays. Sliding at low Ca2+ (diastolic dysfunction) with cTnI R145G is worsened by cTnT R278C.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNNT2 antibody

Reference Product	PubMed Publications
MYBPC3 antibody	>72 publications with TNNT2 and MYBPC3
TNNI3 antibody	>56 publications with TNNT2 and TNNI3
TPM1 antibody	>36 publications with TNNT2 and TPM1
MYL2 antibody	>22 publications with TNNT2 and MYL2
MYL3 antibody	>19 publications with TNNT2 and MYL3
TNNC1 antibody	>13 publications with TNNT2 and TNNC1
TTN antibody	>8 publications with TNNT2 and TTN
TNNI2 antibody	>1 publications with TNNT2 and TNNI2
TNNI1 antibody	>1 publications with TNNT2 and TNNI1

Pathways associated with anti-TNNT2 antibody

Products by Pathway	Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Cardiac Progenitor Differentiation Pathway antibodies	Cardiac Progenitor Differentiation Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Muscle Contraction Pathway antibodies	Muscle Contraction Pathway Diagram

Diseases associated with anti-TNNT2 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>153 publications with TNNT2 and Cardiovascular Diseases
Heart Diseases Antibodies	>150 publications with TNNT2 and Heart Diseases
Cardiomyopathies Antibodies	>115 publications with TNNT2 and Cardiomyopathies
Cardiomyopathy, Hypertrophic Antibodies	>102 publications with TNNT2 and Cardiomyopathy, Hypertrophic
Cardiomyopathy, Hypertrophic, Familial Antibodies	>47 publications with TNNT2 and Cardiomyopathy, Hypertrophic, Familial
Cardiomyopathy, Dilated Antibodies	>44 publications with TNNT2 and Cardiomyopathy, Dilated
Cardiomegaly Antibodies	>40 publications with TNNT2 and Cardiomegaly
Hypertrophy Antibodies	>39 publications with TNNT2 and Hypertrophy
Heart Failure Antibodies	>35 publications with TNNT2 and Heart Failure
Death, Sudden, Cardiac Antibodies	>33 publications with TNNT2 and Death, Sudden, Cardiac

Organs/Tissues associated with anti-TNNT2 antibody

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>117 publications with TNNT2 and Heart
Muscle Antibodies	>94 publications with TNNT2 and Muscle
Blood Antibodies	>48 publications with TNNT2 and Blood
Embryonic Tissue Antibodies	>15 publications with TNNT2 and Embryonic Tissue
Kidney Antibodies	>7 publications with TNNT2 and Kidney
Lung Antibodies	>4 publications with TNNT2 and Lung
Brain Antibodies	>4 publications with TNNT2 and Brain
Connective Tissue Antibodies	>2 publications with TNNT2 and Connective Tissue
Liver Antibodies	>2 publications with TNNT2 and Liver
Eye Antibodies	>1 publications with TNNT2 and Eye