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TRIP6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150280

TRIP6 Antibody: TRIP6 (Thyroid receptor interacting protein 6) is a zyxin-related focal adhesion molecule involved in cell motility and antiapoptotic responses. TRIP6 is predominantly expressed in kidney, liver and lung. It has three LIM domains, a… More details

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Product Overview

Online Datasheet in PDF
Product Name
TRIP6, Polyclonal Antibody
Full Product Name
TRIP6 Antibody
Product Gene Name
anti-TRIP6 antibody
Product Synonym Names
TRIP6; OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2; OIP1; Thyroid receptor-interacting protein 6; Opa-interacting protein 1; TR-interacting protein 6; thyroid hormone receptor interactor 6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
TRIP6 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
TRIP6 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
TRIP6 peptide (MBS152303) is used for blocking the activity of TRIP6 antibody (MBS150280)
Molecular Weight
8,277 Da
OMIM
602933
3D Structure
ModBase 3D Structure for Q15654
Conjugate
Unconjugated
Immunogen
TRIP6 antibody was raised against a 15 amino acid synthetic peptide near the center of human TRIP6.
Buffer
TRIP6 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-TRIP6 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-TRIP6 antibody
TRIP6 antibody can be used for detection of TRIP6 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-TRIP6 antibody

Western blot analysis of TRIP6 in A431 cell lysate with TRIP6 antibody at 1 μg/mL.
Rabbit Anti-TRIP6 Polyclonal Antibody – Cat# MBS150280

Immunocytochemistry (IHC) of anti-TRIP6 antibody

Immunocytochemistry of TRIP6 in HeLa cells with TRIP6 antibody at μg/mL.
Rabbit Anti-TRIP6 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS150280

Immunofluorescence (IF) of anti-TRIP6 antibody

Immunofluorescence of TRIP6 in HeLa cells with TRIP6 antibody at 20 μg/mL.
Rabbit Anti-TRIP6 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150280

Other Notes

Small volumes of anti-TRIP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRIP6 purchase

MBS150280 is an antibody targeting TRIP6. Also known as TRIP6 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIP6. It may not necessarily be applicable to this product.

NCBI GI #
91208423
NCBI GeneID
7205
NCBI Accession #
NP_003293
UniProt Primary Accession #
Q15654
UniProt Secondary Accession #
O15170; O15275; Q9BTB2; Q9BUE5; Q9BXP3; Q9UNT4; A4D2E7; F2ZC07; F2ZC08
UniProt Related Accession #
Q15654
GenBank Nucleotide #
NM_003302.2
NCBI Official Full Name
thyroid receptor-interacting protein 6
NCBI Official Synonym Full Names
thyroid hormone receptor interactor 6
NCBI Official Symbol
TRIP6
NCBI Official Synonym Symbols
OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2
UniProt Protein Name
Thyroid receptor-interacting protein 6
UniProt Synonym Protein Names
Opa-interacting protein 1; OIP-1; Zyxin-related protein 1; ZRP-1
Protein Family
Thyroid receptor-interacting protein
UniProt Gene Name
TRIP6
UniProt Synonym Gene Names
OIP1; TR-interacting protein 6; TRIP-6; OIP-1; ZRP-1
UniProt Entry Name
TRIP6_HUMAN
NCBI Protein Information
thyroid receptor-interacting protein 6; zyxin related protein 1; TR-interacting protein 6; OPA-interacting protein 1; thyroid hormone receptor interacting protein 6

NCBI Summary for TRIP6

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
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UniProt Comments for TRIP6

TRIP6: thyroid receptor interacting protein 6 specifically interacts with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with PTPN13. Functions downstream of the activated LPA(2) receptor and is involved in cell adhesion and migration.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: interleukin-1 receptor complex; focal adhesion; cytoskeleton; cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; interleukin-1 receptor binding; zinc ion binding; thyroid hormone receptor binding; kinase binding

Biological Process: release of cytoplasmic sequestered NF-kappaB; focal adhesion formation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of cell migration
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Research Articles on TRIP6

1. TRIP6 acts, in contrast to Zyxin, as an oncogene that partially accounts for the autonomous migratory, invasive and proliferative properties of Ewing's sarcoma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRIP6 antibody

 Reference Product  PubMed Publications
 SRC antibody  >8 publications with TRIP6 and SRC
 CRK antibody  >4 publications with TRIP6 and CRK
 PTPN13 antibody  >3 publications with TRIP6 and PTPN13
 JUN antibody  >2 publications with TRIP6 and JUN
 FOS antibody  >2 publications with TRIP6 and FOS
 RIPK2 antibody  >1 publications with TRIP6 and RIPK2
 PTK2 antibody  >1 publications with TRIP6 and PTK2

Pathways associated with anti-TRIP6 antibody

 Products by Pathway  Pathway Diagram
 LPA Receptor Mediated Events Pathway antibodies  LPA Receptor Mediated Events Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram

Diseases associated with anti-TRIP6 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with TRIP6 and Inflammation
 Necrosis Antibodies  >2 publications with TRIP6 and Necrosis
 Breast Neoplasms Antibodies  >1 publications with TRIP6 and Breast Neoplasms
 Nervous System Diseases Antibodies  >1 publications with TRIP6 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with TRIP6 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-TRIP6 antibody

 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >37 publications with TRIP6 and Thyroid
 Muscle Antibodies  >3 publications with TRIP6 and Muscle
 Bone Antibodies  >2 publications with TRIP6 and Bone
 Intestine Antibodies  >2 publications with TRIP6 and Intestine
 Blood Antibodies  >1 publications with TRIP6 and Blood
 Pancreas Antibodies  >1 publications with TRIP6 and Pancreas
 Skin Antibodies  >1 publications with TRIP6 and Skin
 Embryonic Tissue Antibodies  >1 publications with TRIP6 and Embryonic Tissue
 Spleen Antibodies  >1 publications with TRIP6 and Spleen
 Lung Antibodies  >1 publications with TRIP6 and Lung
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