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TSSK4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9212236

This gene encodes a member of the testis-specificserine/threonine kinase family. The encoded protein is thought tobe involved in spermatogenesis via stimulation of the CREB/CREresponsive pathway through phosphorylation of the cAMP responsiveelement binding… More details

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Product Overview

Online Datasheet in PDF
Product Name
TSSK4, Polyclonal Antibody
Full Product Name
TSSK4 Antibody (C-term)
Product Gene Name
anti-TSSK4 antibody
Product Synonym Names
Testis-specific serine/threonine-protein kinase 4; TSK-4; TSSK-4; Testis-specific kinase 4; Serine/threonine-protein kinase 22E; TSSK4; C14orf20; STK22E; TSSK5
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Mouse)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This TSSK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the C-terminal region of human TSSK4.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
TSSK4 peptide (MBS9218257) is used for blocking the activity of TSSK4 antibody (MBS9212236)
Molecular Weight
37454
Immunogen Sequence Positions
226-254
OMIM
610711
3D Structure
ModBase 3D Structure for Q6SA08
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Applications Tested/Suitable for anti-TSSK4 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TSSK4 antibody
WB~~1:1000

Western Blot (WB) of anti-TSSK4 antibody

Western blot analysis of TSSK4 (arrow) using rabbit polyclonal TSSK4 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the TSSK4 gene.
Rabbit Anti-TSSK4 Polyclonal Antibody – Cat# MBS9212236

Immunohistochemistry (IHC) of anti-TSSK4 antibody

TSSK4 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TSSK4 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-TSSK4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9212236

Immunofluorescence (IF) of anti-TSSK4 antibody

Confocal immunofluorescent analysis of TSSK4 Antibody (C-term) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-TSSK4 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9212236

Product References and Citations for anti-TSSK4 antibody

Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Su, D., et al. J. Androl. 29(4):374-378(2008)
Zeng, M., et al. BMB Rep 41(4):300-304(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Chen, X., et al. Biochem. Biophys. Res. Commun. 333(3):742-749(2005)

Other Notes

Small volumes of anti-TSSK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TSSK4 purchase

MBS9212236 is an antibody targeting TSSK4. Also known as TSSK4 Antibody (C-term). Reactive in Human (Predicted Reactivity: Mouse). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TSSK4. It may not necessarily be applicable to this product.

NCBI GI #
296317364
NCBI GeneID
283629
NCBI Accession #
NP_001171668.1
NCBI Related Accession #
NP_777604.2
UniProt Primary Accession #
Q6SA08
UniProt Secondary Accession #
Q2TA60; Q6ZNM2
UniProt Related Accession #
Q6SA08
GenBank Nucleotide #
NM_001184739.1
NCBI Official Full Name
testis-specific serine/threonine-protein kinase 4 isoform 1
NCBI Official Synonym Full Names
testis-specific serine kinase 4
NCBI Official Symbol
TSSK4
NCBI Official Synonym Symbols
TSK4; TSK-4; TSSK5; STK22E; C14orf20
UniProt Protein Name
Testis-specific serine/threonine-protein kinase 4
UniProt Synonym Protein Names
Serine/threonine-protein kinase 22E
Protein Family
Testis-specific serine/threonine-protein kinase
UniProt Gene Name
TSSK4
UniProt Synonym Gene Names
C14orf20; STK22E; TSSK5; TSK-4; TSSK-4; Testis-specific kinase 4
UniProt Entry Name
TSSK4_HUMAN
NCBI Protein Information
testis-specific serine/threonine-protein kinase 4

NCBI Summary for TSSK4

This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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UniProt Comments for TSSK4

TSSK4: May be involved in a signaling pathway during male germ cell development or mature sperm function. Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, CAMK; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; TSSK family

Chromosomal Location of Human Ortholog: 14q12

Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding

Biological Process: multicellular organismal development; activation of CREB transcription factor; regulation of signal transduction; spermatogenesis; cell differentiation; protein amino acid phosphorylation
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Research Articles on TSSK4

1. association of some single nucleotide polymorphisms in TSSK4 with male infertility.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TSSK4 antibody

 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >1 publications with TSSK4 and Infertility, Male

Organs/Tissues associated with anti-TSSK4 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >8 publications with TSSK4 and Testis
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