USF1 Antibody – Rabbit Polyclonal

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]

USF1: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an homodimer or a heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function: bHLH transcription factor binding; enzyme binding; histone deacetylase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding

Biological Process: cellular response to insulin stimulus; glucose homeostasis; late viral mRNA transcription; lipid homeostasis; negative regulation of fibrinolysis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by glucose; regulation of transcription by carbon catabolites; regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter by glucose; response to hypoxia; response to UV; transcription from RNA polymerase II promoter

Disease: Hyperlipidemia, Combined, 1