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USP10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150568

USP10 Antibody: USP10, also known as ubiquitin specific peptidase 10, belongs to the ubiquitin-specific protease family of cysteine proteases. USP10 functions to catalyze the cleavage of ubiquitin from ubiquitin-conjugated protein substrates such as p53/TP53,… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
USP10, Polyclonal Antibody
Full Product Name
USP10 Antibody
Product Gene Name
anti-USP10 antibody
Product Synonym Names
USP10; UBPO; KIAA0190; Ubiquitin carboxyl-terminal hydrolase 10; Deubiquitinating enzyme 10; ubiquitin specific peptidase 10
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
USP10 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
USP10 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
USP10 peptide (MBS153231) is used for blocking the activity of USP10 antibody (MBS150568)
Molecular Weight
87,533 Da
OMIM
609818
3D Structure
ModBase 3D Structure for Q14694
Conjugate
Unconjugated
Immunogen
USP10 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human USP10.
Buffer
USP10 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-USP10 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-USP10 antibody
USP10 antibody can be used for detection of USP10 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-USP10 antibody

Western blot analysis of USP10 in Jurkat cell lysate with USP10 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-USP10 Polyclonal Antibody – Cat# MBS150568

Immunocytochemistry (IHC) of anti-USP10 antibody

Immunocytochemistry of USP10 in Jurkat cells with USP10 antibody at 20 μg/mL.
Rabbit Anti-USP10 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS150568

Immunofluorescence (IF) of anti-USP10 antibody

Immunofluorescence of USP10 in Jurkat cells with USP10 antibody at 20 μg/mL.
Rabbit Anti-USP10 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150568

Other Notes

Small volumes of anti-USP10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for USP10 purchase

MBS150568 is an antibody targeting USP10. Also known as USP10 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for USP10. It may not necessarily be applicable to this product.

NCBI GI #
119220605
NCBI GeneID
9100
NCBI Accession #
NP_005144
UniProt Primary Accession #
Q14694
UniProt Secondary Accession #
Q9BWG7; Q9NSL7; B2RDJ8; B4DS84
UniProt Related Accession #
Q14694
GenBank Nucleotide #
NM_005153.2
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase 10 isoform 2
NCBI Official Synonym Full Names
ubiquitin specific peptidase 10
NCBI Official Symbol
USP10
NCBI Official Synonym Symbols
UBPO
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 10
UniProt Synonym Protein Names
Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10
UniProt Gene Name
USP10
UniProt Synonym Gene Names
KIAA0190
UniProt Entry Name
UBP10_HUMAN
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 10; ubiquitin thioesterase 10; deubiquitinating enzyme 10; ubiquitin thiolesterase 10; ubiquitin specific protease 10; ubiquitin-specific-processing protease 10

NCBI Summary for USP10

Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
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UniProt Comments for USP10

USP10: a carboxyl-terminal ubiquitin-processing protease. Ras-GAP SH3 domain-binding protein (G3BP) appears to inhibit its ability to disassemble ubiquitin chains.

Protein type: RNA-binding; EC 3.4.19.12; Ubiquitin-specific protease; Ubiquitin conjugating system; Protease

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: cytoplasm; early endosome; nucleus

Molecular Function: protein binding; p53 binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; DNA damage response, signal transduction by p53 class mediator; autophagy; regulation of autophagy; DNA repair
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Research Articles on USP10

1. USP10 deubiquitinates and stabilizes SIRT6.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-USP10 antibody

 Reference Product  PubMed Publications
 G3BP1 antibody  >8 publications with USP10 and G3BP1
 CFTR antibody  >4 publications with USP10 and CFTR
 G3BP2 antibody  >2 publications with USP10 and G3BP2
 SNX3 antibody  >1 publications with USP10 and SNX3

Diseases associated with anti-USP10 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >6 publications with USP10 and Carcinoma
 Fibrosis Antibodies  >5 publications with USP10 and Fibrosis
 Neoplasms, Experimental Antibodies  >3 publications with USP10 and Neoplasms, Experimental
 Prostatic Diseases Antibodies  >2 publications with USP10 and Prostatic Diseases
 Liver Diseases Antibodies  >2 publications with USP10 and Liver Diseases
 Inflammation Antibodies  >2 publications with USP10 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >2 publications with USP10 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with USP10 and Liver Neoplasms
 Disease Models, Animal Antibodies  >1 publications with USP10 and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with USP10 and Kidney Diseases

Organs/Tissues associated with anti-USP10 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with USP10 and Blood
 Kidney Antibodies  >4 publications with USP10 and Kidney
 Prostate Antibodies  >3 publications with USP10 and Prostate
 Lung Antibodies  >3 publications with USP10 and Lung
 Liver Antibodies  >2 publications with USP10 and Liver
 Uncharacterized Tissue Antibodies  >2 publications with USP10 and Uncharacterized Tissue
 Stomach Antibodies  >2 publications with USP10 and Stomach
 Thyroid Antibodies  >1 publications with USP10 and Thyroid
 Bone Marrow Antibodies  >1 publications with USP10 and Bone Marrow
 Eye Antibodies  >1 publications with USP10 and Eye
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